Trends and an age-period-cohort analysis of testicular cancer incidence and mortality in China from 1990 to 2021.

Background: The testicular cancer incidence rate in China has been rising since 1990, which has brought a huge burden to China, but its influencing factors are still under discussion. This study aims to investigate the trends of testicular cancer incidence and mortality in China from 1990 to 2021.

Methods: The trends were estimated by the Estimated Annual Percentage Change model and Joinpoint regression analysis model using the data from GBD 2021, and the influence of age, period, and birth cohort on testicular cancer within the analysis model of age-period-cohort.

Dual Prototypical Self-Supervised Learning for One-shot Medical Image Segmentation.

Medical image segmentation using deep learning typically requires a large quantity of well-annotated data. However, the acquisition of pixel-level annotations is arduous and expensive, often requiring the expertise of experienced medical professionals. Recent advancements in few-shot learning can help address label scarcity in medical image segmentation by leveraging a small amount of labeled data.

Learning High-Quality Dynamic Memory for Video Object Segmentation.

Recently, several spatial-temporal memory-based methods have verified that storing intermediate frames with masks as memory helps segment target objects in videos. However, they mainly focus on better matching between the current frame and memory frames without paying attention to the quality of the memory. Consequently, frames with poor segmentation masks may be memorized, leading to error accumulation problems.

A topic modeling-based analysis of emerging mobility services for carbon emission reduction.

Introduction: With rising urbanization and global climate change, sustainable city development has become an urgent challenge. Emerging mobility services provide innovative solutions for sustainable city governance, bridging the gap between transportation demand and supply, alleviating city travel and reducing carbon emissions. However, further investigation is needed to ascertain the specific roles and potential enhancements that emerging mobility services could contribute to reducing carbon emissions.

Complexation of CcmB with CcmACD safeguards heme translocation for cytochrome maturation.

Cytochrome maturation (CCM), a posttranslational modification involving covalent attachment of heme to polypeptides (apocyt ), is essential for the activity and cellular function of cytochromes . Here, we identify and substantiate CcmB as heme translocase in bacteria. When in excess, CcmB expels intracellular heme into the periplasm and thus is detrimental to the cell.

Development of Self-Aligned Top-Gate Transistor Arrays on Wafer-Scale Two-Dimensional Semiconductor.

Two-dimensional semiconductor materials (2DSM) effectively mitigate the short-channel effect due to their atomic thickness, offering significant advantages over traditional silicon-based materials, particularly in short channel length. In manufacturing 2DSM top-gate field-effect transistors (TG-FETs), simultaneous miniaturization of the gate and channel can only be achieved through a self-alignment process, enabling high-density integration of short-channel FETs. However, current self-aligned FETs based on 2DSM face challenges in attaining wafer-scale integration due to manufacturing process limitations.

Energy efficiency and carbon savings via a body grid.

The climate crisis necessitates decarbonization solutions that transform energy systems across all scales. While attention today focuses on utility-scale power systems, mini-or metro-scale grids, and at end-use device efficiency, the individual user scale remains underexplored. Just as with energy efficiency innovations tailored to micro-environments, body-scale energy savings offer new opportunities alongside technological and behavioral challenges.

Human cytomegalovirus UL82 promotes cell cycle progression of colorectal cancer by upregulating AGR2.

The correlation between persistent human cytomegalovirus (HCMV) infection and poor prognosis in colorectal cancer (CRC) patients has garnered increasing attention. UL82 is a tegument protein of HCMV, and our previous research indicated that the presence of UL82 is significantly associated with reduced overall survival in CRC patients. However, the mechanism by which UL82 affects the prognosis of CRC patients remains unclear.

Advancing Src kinase inhibition: From structural design to therapeutic innovation - A comprehensive review.

Src kinase, a non-receptor tyrosine kinase implicated in cellular signaling networks, plays a pivotal role in tumor progression and therapeutic resistance. Despite intensive research efforts spanning decades, no Src-selective kinase inhibitors have yet entered clinical use, highlighting the challenges in developing targeted therapeutics. Here we review recent advances in small-molecule Src inhibitor development, focusing on structural design strategies, binding mechanisms, and therapeutic applications.

Causal relationship between periodontitis and prostate diseases: a bidirectional Mendelian randomization study.

Background: There is currently evidence supporting an association between periodontitis and prostate disease, but further research is needed to establish a causal relationship due to potential confounding factors and uncertainty about the direction of causality. The present study employs a bidirectional Mendelian Randomization (MR) analysis to eliminate confounding factors at the genetic level and determine the causal relationship between periodontitis and prostate diseases.

Methods: Summary data for periodontitis were obtained from the GLIDE consortium (N = 45,563), while data for prostate diseases, including benign prostatic hyperplasia (N = 163,095), prostatitis (N = 134,299), and prostate cancer (N = 146,465), were sourced from the FinnGen database.

Discrimination of natural and cultured populations in Zhoushan sea area based on otolith morphology.

To effectively distinguish natural and cultured populations of , we used both traditional statistical analysis and neural network methods to compare six shape indices and twenty-one truss indices from otoliths of 174 randomly selected specimens (100 from a natural population and 74 from a cultured population). The results showed that among the six shape indices, ellipticity, roundness, and aspect ratio exhibited significant differences between the two populations. Twelve out of the twenty-one truss indices displayed significant differences.

Recent advances in functional assays of WRKY transcription factors in plant immunity against pathogens.

WRKY transcription factors (TFs) are one of the largest transcription factor families in plants and play important roles in plant processes, most notably in responding to diverse biotic and abiotic stresses. This article reviews the recent research progresses on WRKY TFs in regulating plant immunity, which includes both positive and negative regulation. WRKY TFs were shown to regulate plant defense against pathogens including fungi, bacteria, oomycetes, and viruses by modulating downstream pathogen resistance genes or interacting with other regulators.

Discovery of E0199: A novel compound targeting both peripheral Na and K7 channels to alleviate neuropathic pain.

This research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both Na1.7, Na1.8, and Na1.

Protonation-Independent Charge Transport Across Diphenylamine Single-Molecule Junctions.

Amines are one of the most ubiquitous functional groups in molecular junctions; however, the exact regulation of the charge transport through the protonation state of an amine group in the junction backbone remains elusive. We address this question here by designing a diphenylamine molecular backbone and experimentally investigating how protonation of the central amine group affects the charge transport. Our ultraviolet-visible spectroscopy measurements demonstrate the protonation reaction of the diphenylamine compound in the presence of either trifluoroacetic acid or HCl, and we observe a consistent trend of a modestly increased conductance for diphenylamine in the presence of acid, indicating that a protonated amine group in a diphenylamine backbone slightly enhances the electron conduction.

Cost-effective production of meaty aroma from porcine cells for hybrid cultivated meat.

Cultivated meats are typically hybrids of animal cells and plant proteins, but their high production costs limit their scalability. This study explores a cost-effective alternative by hypothesizing that controlling the Maillard and lipid thermal degradation reactions in pure cells can create a meaty aroma that could be extracted from minimal cell quantities. Using spontaneously immortalized porcine myoblasts and fibroblasts adapted to suspension culture with a 1 % serum concentration, we developed a method to isolate flavor precursors via freeze-thawing.

PDGFR-α shRNA encoded nanoparticle with epithelial mesenchymal transformation interfering for corneal scarring treatment.

Maintaining the clarity of the cornea is crucial for optimal vision. Corneal scarring (CS), resulting from corneal inflammation, trauma, or surgery, can lead to a reduction in corneal transparency and visual impairment. While corneal transplantation is the primary method for restoring vision, the limited availability of corneal donor presents a significant challenge on a global scale.

Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells .

Background: Oxyberberine (OBB) is a naturally occurring isoquinoline alkaloid that is believed to possess various health-promoting properties, including anti-fungus, hepatoprotection, anti-inflammation, and anti-intestinal mucositis effects. Despite several studies reporting the health benefits of OBB in treating ulcerative colitis (UC), its specific mechanism of action has yet to be fully elucidated.

Purpose: This investigation is designed to explore the potential protective efficacy of OBB and the latent mechanism using an model of UC-like inflammatory intestinal cells.

Phytochemical analysis of dried ginger extract and its inhibitory effect and mechanism on and associated ureases.

(), one of the most common infectious pathogens in the world, can cause gastritis, digestive ulcers, and even gastric cancer. urease (HPU) is a distinctive virulence factor of that allows it to be distinguished from other pathogens. Dried ginger is a famous edible and medicinal herb that is commonly used to prevent and treat gastrointestinal tract-related diseases.

The efficacy and safety of Baduanjin exercise as complementary therapy for pain reduction and functional improvement in knee osteoarthritis: A meta-analysis of randomized controlled trials.

Objectives: To systematically evaluate the efficacy and safety of Baduanjin exercise in patients with knee osteoarthritis through meta-analysis. While Baduanjin exercise, a traditional Chinese exercise therapy, is part of complementary and alternative medicine, its therapeutic value for knee osteoarthritis remains uncertain due to limited supporting evidence. This study seeks to address this gap.

Construction of lignin-derived microcapsule anti-mildew system with excellent anti-loss performance for Masson pine wood protection.

Masson pine wood is widely used in living spaces, decoration, and construction. Owing to its high sugar content and tendency to mold. Masson pine wood has been treated with anti-mildew agents.

Characteristics of OSA modified starch-based Pickering emulsion and its application to myofibrillar protein gel.

Background: Pickering emulsions prepared with octenyl succinic anhydride-modified starch (OSAS) show significant promise as replacements for animal fat. However, the underlying mechanism of incorporating an OSAS-based Pickering emulsion into a myofibrillar protein (MP) gel and its impact on the gel properties remain poorly understood. In this study, the effects of OSAS at varying concentrations (0-10.

Prognostic value of the triglyceride-glucose index in non-muscle-invasive bladder cancer: a retrospective study.

Background: Bladder carcinoma is a type of urological tumor with high risks of recurrence and progression. The triglyceride-glucose (TyG) index has demonstrated significant promise as a prognostic marker for metabolic health in different types of cancer. Further research is needed to explore the relationships among non-muscle-invasive bladder cancer (NMIBC), the TyG index, and its prognostic importance.

PDGFR-α shRNA-polyplex for uveal melanoma treatment via EMT mediated vasculogenic mimicry interfering.

Up to 50% of individuals with uveal melanoma (UM), a frequent cancer of the eye, pass away from metastases. One of the major challenges in treating UM is the role of receptor tyrosine kinases (RTKs), which mediate the epithelial-mesenchymal transition (EMT) of tumors. RTKs are involved in binding multiple growth factors, leading to angiogenesis and vasculogenic mimicry (VM) phenomena.

[Preparation of Silicon-based Magnetic Biochar and Its Remediation Mechanism for Cd（Ⅱ） and As（Ⅲ） Co-contaminated Water].

Cadmium （Cd） and arsenic （As） often coexist in water and agricultural soils around mining areas, and it is difficult to remove them at the same time due to their opposite chemical behaviors. Therefore, this study employed a co-precipitation-pyrolysis method to synthesize silica-based magnetic biochar （SMB） materials for the remediation of water contaminated with both Cd and As. The optimization of preparation conditions involved introducing three different types of silicates （NaSiO, CaSiO,and SiO） into the biomass-magnetite mixture, followed by pyrolysis at various temperatures （300℃, 500℃, and 700℃）, and the optimal preparation conditions were determined based on the composite batch experiments.

Perforated imprinting on high moisture meat analogue confers long range mechanical anisotropy resembling meat cuts.

Meat cuts, when cooked and masticated, separate into fibrous structures because of the long-range mechanical anisotropy (LMA) exhibited by muscle fascicles, which is not fully recapitulated in alternative proteins produced using molecular alignment technology like high moisture extrusion. We have developed a scalable perforated micro-imprinting technology to greatly enhance LMA in high moisture meat analogue (HMMA). By imprinting 1 mm thick HMMA sheets with perforated patterns (optimized by AI), we observed up to 5 × more anisotropic separation of fibrous structures in a one-dimensional pulling LMA analysis, to match the fibrousness of the cooked chicken breast, duck breast, pork loin and beef loin.