Longitudinal associations of serum survivin with the severity and prognosis of community-acquired pneumonia patients.

Background: Survivin is a member of apoptosis inhibitor proteins that evokes cellular proliferation and inhibits apoptosis. However, the role of survivin in community-acquired pneumonia (CAP) patients remains to be firmly established. The aim of this cohort study was to evaluate the correlations of serum survivin with the severity and prognosis of CAP patients.

Cross-sectional and longitudinal associations of serum Cysteine-rich 61 with severity and prognosis among community-acquired pneumonia patients in China.

Background: Cysteine-rich 61 (CYR61) is implicated in many pulmonary diseases. However, the relationship between CYR61 and community-acquired pneumonia (CAP) patients was unknown. This research aimed to estimate the correlations of serum CYR61 with severity and prognosis in CAP patients through a prospective cohort study.

Serum Level of 4-Hydroxynonenal in Community-Acquired Pneumonia: A Potential Biomarker for Severity and Prognosis.

Background: Four-hydroxynonenal (4-HNE) exerts a central role in the pathophysiological process of pulmonary diseases. The aim of this project was to evaluate the correlations between serum 4-HNE with severity and prognosis in patients with community-acquired pneumonia (CAP) by a prospective cohort study.

Materials And Methods: A total of 239 patients with CAP and healthy volunteers were recruited.

Serum 8-Hydroxydeoxyguanosine Is a Potential Indicator for the Severity and Prognosis in Patients with Community-Acquired Pneumonia: A Prospective Cohort Study.

Previous studies have demonstrated that 8-hydroxydeoxyguanosine (8-OHdG) exerted key roles in various pulmonary diseases, but the evidence for its role in community-acquired pneumonia (CAP) was lacking. The goal of this research was to evaluate the correlations of serum 8-OHdG with the severity and prognosis among patients with CAP through a prospective cohort study. A total of 239 patients with CAP and 239 healthy participants were enrolled.

Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia.

Background: Resistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function of resistin in community-acquired pneumonia (CAP) remains unknown. The goal of this research was to explore the associations between serum resistin and the severity and prognosis in CAP patients through a retrospective cohort study.

Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study.

Background: Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study.

A berberrubine-derived fluorescent probe for hydrazine and its practical application in water and food samples.

In this work, we attempted to develop a fluorescent probe for hydrazine in real samples. Accordingly, we designed BER9-HZ to fulfill the set rules as solubility, anti-interference capability and functional compatibility. The selected reporting group BER9 dissolved 100% within 10 min, which indicated much better solubility than Berberine.

Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents and .

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities and . The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells , of which 3-(6-chloro-9-purin-9-yl)dodecan-1-ol () exhibited the most potent effect against the HCT-116 and SW480 cells with IC values of 0.89 and 1.

Metabolism and Pharmacological Mechanisms of Active Ingredients in .

Background: Erigeron breviscapus (Vant.) Hand-Mazz. is a plant species in the Compositae family.

[Occurrence, Input, and Seasonal Variations of Poly-and Perfluoroalkyl Substances (PFASs) in Rivers and Drain Outlets from the Dalian Coastal Area, China].

Concentrations of 19 PFASs (poly-and perfluoroalkyl substances) in riverwater, coastal wastewater, and effluents from wastewater treatment plants (WWTPs) directly discharged into the Dalian coastal area were measured and their inputs were calculated accordingly. For riverwater samples, the total PFAS concentration ranged from 9.85 to 757 ng·L, with a median of 74.

[Protection and mechanism of total flavone of Hippophae rhamnoides on vascular endothelial cells].

Objective: To observe the protection of total flavones of Hippophae Rhamnoides (TFH) on vascular endothelial cells (VECs).

Methods: Human umbilical VECs (ECV304) were used. The vascular endothelial injured cell model was prepared using hydrogen dioxide (H2O2).

[Discussion on pharmacological mechanism of laosun kangfu tablets].

Objective: to study pharmacological mechanism of Laosun Kangfu tablet.

Method: Blood-activating and stasis-removing was tested by establishing cute cold pathogens induced blood stasis rat model and microcirculation disturbance state rat model by means of dripping adrenine on the mensentery. The resisting oxidation was tested by establishing the freely falling body damages models.