LncRNA GNAS-AS1 knockdown inhibits keloid cells growth by mediating the miR-188-5p/RUNX2 axis.

Keloid is a common dermis tumor, occurring repeatedly, affecting the quality of patients' life. Long non-coding RNAs (lncRNAs) have crucial regulatory capacities in skin scarring formation and subsequent scar carcinogenesis. The intention of this study was to investigate the mechanism and function of GNAS antisense-1 (GNAS-AS1) in keloids.

Intelligent porphyrin nano-delivery system for photostimulated and targeted inhibition of angiogenesis.

As a first-line anticancer drug, sunitinib (SUN) can significantly inhibit tumor growth through an antiangiogenic effect. The nanocarrier drug-delivery strategy has been rapidly developed to improve therapeutic efficiency and drug safety. This study designed an intelligent liposome-like nanoporphyrin to broaden the application range of sunitinib.

Design of GeSn-on-Si waveguide photodetectors featuring high-speed high-sensitivity photodetection in the C- to U-bands.

We present the design of -on-Si waveguide photodetectors for the applications in the C- to U-bands. The GeSn photodetectors have been studied in respect to responsivity, dark current, and bandwidth, with light butt- or evanescent-coupled from an Si waveguide. With the introduction of 4.

[Analysis of p53 gene mutation in salivary adenoid cystic carcinoma.].

Purpose: The purpose of this study was to investigate the occurrence of p53 gene mutation in salivary adenoid cystic carcinoma, the correlation between the gene and prognostic significance.

Methods: A series of salivary adenoid cystic carcinoma were studied by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis to detect p53 mutation, respectively.

Results: The result showed that p53 gene mutations in exon 5-8 were detected in 65.

[Study on the treatment of high dose mifepristone and progesterone in endometrial carcinoma].

Objective: To investigate the effect of high dose mifepristone and high dose progesterone in the treatment of patients with endometrial carcinoma and to explore the possible mechanisms associating with them.

Methods: Thirty untreated patients diagnosed as endometrial carcinoma through dilation and curettage of the uteri were divided into 3 groups at random. Each group was given medroxyprogesterone acetate (MPA), (500 mg/day) or mifepristone (MIF), (100 mg/day) or MIF (100 mg/day) + MPA (500 mg/day) for 5 days respectively.