Bone loss in patients with spinal cord injury: Incidence and influencing factors.

Purpose: To investigate the incidence and influencing factors of bone loss in patients with spinal cord injury (SCI).

Methods: A retrospective case-control study was conducted. Patients with SCI in our hospital from January 2019 to March 2023 were collected.

Primary intramedullary melanocytoma presenting with lower limbs, defecation, and erectile dysfunction: A case report and review of the literature.

Background: Primary intramedullary melanocytoma is an exceedingly rare type of primary melanocytic tumor in the central nervous system. Unfortunately, primary intramedullary melanocytoma lacks specificity in clinical symptoms and imaging features and there is currently no standard strategy for diagnosis or treatment.

Case Summary: A 52-year-old male patient suffered from weakness and numbness involving the bilateral lower limbs for 18 mo, and defecation and erectile dysfunction for 6 mo.

Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives.

Since pyrithiobac (PTB) is a successful commercial herbicide with very low toxicity against mammals, it is worth exploring its derivatives for an extensive study. Herein, a total of 35 novel compounds were chemically synthesized and single crystal of 6-6 was obtained to confirm the molecular structure of this family of compounds. The novel PTB derivatives were fully evaluated against various biological platforms.

[Study on quantitative mechanism and the interference of the UV spectrum of HABS reduced by β-Cyclodextrin].

A novel ultraviolet absorption spectrometry method was developed for the quantitative determination of HABS by adding β-cyclodextrin with the molar ratio of 1:1 in strong interference aqueous solution. The results indicated that the effect of several common interfering flooding agents (SAS, OP-10, HPAM) on the determination of HABS could be greatly reduced in β- cyclodextrin aqueous solution. Thus, the determination errors of the determined HABS were less than 2.

[Study on the enhanced spectrum quantitative analysis of SDBS induced by beta-cyclodextrin].

A novel enhanced ultraviolet absorption spectrometry method was developed for the quantitative analysis of SDBS induced by beta-cyclodextrin(beta-CD) with strong interferences. The ultraviolet absorption spectra of SDBS indicated that the presence of beta-CD could result in the enhancement of absorption intensities of SDBS. A good linearity was obtained between the UV-absorption intensity of the system and the concentration of SDBS.

Spectroscopic and molecular modeling studies on the interaction between a fluorine-containing triazole derivative and human serum albumin.

The interaction between 4-(4-fluorobenzylideneamino)-5-propyl-4H-1,2,4-triazole-3-thiol (FBTZ) and human serum albumin (HSA) under simulative physiological conditions was investigated by fluorescence, UV-vis absorption and circular dichroism (CD) spectroscopy as well as molecular modeling method. Fluorescence spectroscopic data showed that the fluorescence quenching of HSA was a result of the formation of FBTZ-HSA complex. According to the modified Stern-Volmer equation, the effective quenching constants (K (a)) of FBTZ to HSA were obtained at three different temperatures.