Publications by authors named "Jia-wang Liu"
Article Synopsis
- This study focuses on peptidyl alkaloids produced by fungal non-ribosomal peptide synthetases (NRPSs), which are often inactive in lab conditions.
- Researchers used bioinformatics to analyze NRPS gene clusters and successfully expressed one such cluster in a heterologous system.
- The expression led to high yields of the compound anacine, which demonstrated moderate cytotoxic activity against cancer cells, highlighting the potential of this method for discovering fungal natural products.
Commiphoranoids A-E (-), five novel sesquiterpenoids, dinorditerpenoids, and heterodimers with unprecedented carbon skeletons, were isolated from . The structure of was secured by X-ray crystallography. Compound represents the first example of C terpenoids, whereas is a C terpenoid formed by two types of sesquiterpenoids.
View Article and Find Full Text PDFFour new compounds including two new sesquiterpenoid dimers, commiphoroids () and (), a new triterpenoid (), and a new sesquiterpenoid (), along with three known terpenoids (-) were isolated from , whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds and both bear an -bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains.
View Article and Find Full Text PDFPopulusone (1), a cembrane-type macrocyclic trinorditerpenoid, was isolated from the exudates of Populus euphratica and shown to have an unprecedented carbon skeleton, The structure was identified using spectroscopic methods and X-ray crystallography. A possible pathway for the biosynthesis of 1 was proposed. Populusone (10 μM) was found to promote proliferation and differentiation of umbilical cord derived mesenchymal stem cells into keratinocyte like cells.
View Article and Find Full Text PDFTwo sesquiterpene dimers, commiphoratones A (1) and B (2), were isolated from Resina Commiphora. Their structures were elucidated by spectroscopic, computational, and crystallographic methods. Compounds 1 and 2 represent an unusual pattern of dimerization between two types of sesquiterpenes.
View Article and Find Full Text PDFArticle Synopsis
- Researchers isolated four new compounds (commiphoroids A-D) from the resin of the Commiphora plant and determined their structures using advanced techniques like spectroscopy and X-ray diffraction.
- Compounds 1 and 2 are related stereoisomers formed through a specific type of chemical reaction, while compounds 3 and 4 have unique and complex structural frameworks.
- Compound 1 has shown promising biochemical effects, notably enhancing the expression of keratinocyte-specific markers in stem cells, which could have implications for skin health at a concentration of 10 μM.
Three new diterpenoids, spicatusenes A-C (1-3), and eleven known ones (4-14) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were identified by spectroscopic methods. The cytotoxic activities of all the compounds against human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) were examined and found that compounds 2, 3, 6, 8, 10, and 13 were active against one or more cancer cell lines.
View Article and Find Full Text PDFObjective: To explore the role of anti-alphabeta T cell receptor (TCR) and anti-CD80 monoclonal antibodies (mAbs) combined with donor bone marrow cells (BMCs) infusion in the induction of murine skin allografts tolerance.
Methods: On day 0, 2 x 10(8) BMCs of BALB/c mice were injected into recipient C57BL/6 mice via the tail vein, meanwhile, an intraperitoneal injection of TCRalphabeta mAb (500 microg) was given. On day 2, CD80 mAb was administered intraperitoneally.