2-Arylbenzofurans from the stems and leaves of and their potential antiproliferative activities.

Phytochemical study on the stems and leaves of led to the isolation of a new 2-arylbenzofuran, artocartone (), as well as seven known 2-arylbenzofurans (). The chemical structure of was established by means of comprehensive spectroscopic analyses and the known compounds were determined by comparing their MS and NMR data with those reported data in literature. The antiproliferative activities of all isolates against five human cancer cell lines: HL-60, SMMC-7721, A-375, MCF-7 and SW480 were evaluated.

[Chemical constituents from stems and leaves of Artocarpus tonkinensis and their inhibitory effects on proliferation of synovioblasts in vitro].

The chemical constituents from the stems and leaves of Artocarpus tonkinensis in Artocarpus of Moraceae were systematically studied by means of silica gel, octadecylsilyl(ODS), and Sephadex LH-20 gel column chromatographies, as well as preparative high-performance liquid chromatography(Pre-HPLC) and a variety of chromatographic separation techniques. The spectral data and physicochemical properties of the compounds were obtained from separation and compared with those of the compounds reported in the literature. As a result, 11 compounds isolated from the 90% ethanol extract of the stems and leaves of A.

Xanthones with Potential Anti-Inflammatory and Anti-HIV Effects from the Stems and Leaves of .

Four new xanthones, cratocochinones A-D (-), together with eight known analogues (-), were isolated from the stems and leaves of . The chemical structures of cratocochinones A-D (-) were elucidated by comprehensive spectroscopic analyses and the known compounds were identified by comparisons with the spectral data reported in the literature. All isolated compounds - were evaluated for their anti-inflammatory activities and anti-HIV-1 activities.

Five new species of Lederer (Lepidoptera, Crambidae) from China, with remarks on the morphology of the genus.

is a species-rich genus that differs from most other Spilomelinae genera because of its distinctive wing venation. Most species of this genus are very similar in appearance. In this study, we have studied morphological characteristics of the genus and eight closely related species from China.

Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.

Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular hydroxyl radicals, acting as an antioxidant, anti-apoptotic and anti-inflammatory agent. We seek to assess the capability of molecular hydrogen to ameliorate brain damage induced by electromagnetic radiation.

AgSbF-catalyzed C3 -Friedel-Crafts alkylation of ,-acetals with indoles for the synthesis of indole substituted pyrrolidine and piperidine derivatives.

An efficient approach to access chiral indole substituted pyrrolidine and piperidine skeletons has been developed through a AgSbF-catalyzed -Friedel-Crafts alkylation of ,-acetals 6a, 6b, 9, and 11a-11d with indoles. As a result, a series of 2,3- indole substituted pyrrolidines 8a-8x and piperidines 10a-10j were prepared in moderate to excellent yields and with excellent diastereoselectivities ( up to 99 : 1). Moreover, several 2,5- indole substituted pyrrolidine derivatives 12a-12k were synthesized according to this strategy with moderate to good yields and diastereoselectivities ( up to 99 : 1).

Molecular Hydrogen Reduces Electromagnetic Pulse-Induced Male Rat Reproductive System Damage in a Rodent Model.

Infertility has got to be a broadly concerned social issue these days, in which the malefactor cannot be overlooked. Numerous studies have shown that electromagnetic pulse (EMP) radiation may have seriously damaging effects on reproductive health, through nonthermal effects and oxidative stress. Molecular hydrogen, a selective hydroxyl radical scavenger, explains the protective effects against many diseases closely associated with oxidative damage, such as ionizing radiation (IR).

SmI-mediated intermolecular addition-elimination of piperidine and pyrrolidine -α-radicals with arylacetylene sulfones.

An efficient approach to access α-arylacetylene-substituted pyrrolidine and piperidine derivatives has been developed through a samarium diiodide-mediated addition-elimination process of pyrrolidine and piperidine -α-radicals with arylacetylene sulfones.

[Quality evaluation of Psoraleae Fructus based on QAMS method and TLC identification].

The present study established a determination method of Psoraleae Fructus by quantitative analysis of multi-components by the single marker(QAMS) and further improved the thin-layer chromatography(TLC) method. The QAMS method was established by UPLC with psoralen as the internal marker, and the content of psoralenoside, isopsoralenoside, psoralen, and isopsoralen was simultaneously determined. As revealed by the comparison with results of the external standard method, the QAMS method was accurate and feasible.

Palladium-Catalyzed Sequential Heck Reactions of Olefin-Tethered Aryl Iodides with Alkenes.

An efficient approach to functionalized ()-3-cinnamyl-3-methyl-2,3-dihydrobenzofurans and ()-(3-methyl-2,3-dihydrobenzofuran-3-yl)but-2-enones has been developed through a Pd-catalyzed one-pot cascade process involving two sequential Heck reactions, that is, an intramolecular Heck reaction of olefin-tethered aryl iodides and an intermolecular Heck reaction with substituted styrenes and α,β-unsaturated ketones. As a result, a series of desired products were obtained in moderate to good yields and with exclusive -form selectivities.

AgNTf catalyzed cycloaddition of -acyliminium ions with alkynes for the synthesis of the 3,4-dihydro-1,3-oxazin-2-one skeleton.

A catalyzed process for the synthesis of the 4,6-substituted 3,4-dihydro-1,3-oxazin-2-one skeleton has been developed through cycloaddition of generated acyliminium intermediates with alkynes. A range of chain ,-acetals and terminal alkynes were amenable for this mild transformation. As a result, a series of desired cycloaddition products were obtained in moderate to good yields.

AgNTf-Catalyzed Regioselective C-H Alkenylation of -Dialkylanilines with Ynamides.

Regioselective C-H alkenylation of -dialkylanilines with ynamides was developed using AgNTf as a catalyst. This approach represents a facile hydroarylation of ynamides, allowing for the introduction of an alkenyl group exclusively at the position of aniline derivatives. As a result, a series of 4-alkenyl -dialkylanilines were synthesized with excellent regioselectivities.

Clausanisumine, a Prenylated Bicarbazole Alkaloid from the Fruits of and Its Potential Anti-HIV Activity.

A unique prenylated bicarbazole alkaloid, clausanisumine (), and two biogenetically related known monomer carbazole alkaloids, mukonal () and 3-methylcarbazole (), were isolated from the fruits of . Clausanisumine () was an uncommon prenylated bicarbazole alkaloid, possessing an unprecedented carbon skeleton, which was composed of a simple carbazole alkaloid and a prenylated carbazole alkaloid. The chemical structure of was established by a combination of comprehensive spectral methods.

[Chemical constituents from Clausena excavata and their inhibitory activities against proliferation of synoviocytes].

The chemical constituents from the stems and leaves of Clausena excavata were isolated and purified by column chromatography with silica gel, ODS, Sephadex LH-20 and RP-HPLC. The chemical structures of the isolated compounds were identified on the basis of physicochemical properties, spectroscopic analysis, as well as the comparisons with the data reported in literature. Nineteen compounds were isolated from the 90% ethanol extract of the stems and leaves of C.

A One-Pot Approach to 2-Substituted-2-(Dimethoxyphosphoryl)-Pyrrolidines from Substituted -Butyl 4-Oxobutylcarbamates and Trimethyl Phosphite.

A novel approach to 2-substituted-2-(dimethoxyphosphoryl)-pyrrolidines - and - has been developed, which features a TMSOTf-mediated one-pot intramolecular cyclization and phosphonylation of substituted -butyl 4-oxobutylcarbamates. The major advantages of this method include simple operation under mild reaction conditions, the use of cheap Lewis acid, and good to excellent yields with high diastereoselectivities ( up to 99:1).

Asymmetric Synthesis of Spiropyrazolones via Chiral Pd(0)/Ligand Complex-Catalyzed Formal [4+2] Cycloaddition of Vinyl Benzoxazinanones with Alkylidene Pyrazolones.

In the presence of the chiral Pd(0)/ligand complex, vinyl benzoxazinanones underwent the [4+2] cycloaddition with alkylidene pyrazolones smoothly and delivered spiropyrazolones in reasonable yields, diastereoselectivities, and eneantioselectivities (up to >99% yield, >99:1 dr and 99% ee). The absolute configuration of the obtained spiropyrazolones was unambiguously characterized with the use of X-ray single-crystal structure analysis. Moreover, the reaction mechanism was assumed to interpret the formation of the target compounds.

Limonoids from the Fresh Young Leaves and Buds of and Their Potential Neuroprotective Effects.

, popularly known as Chinese toon or Chinese mahogany, is a perennial deciduous arbor belonging to the genus in the Meliaceae family, which is widely distributed and cultivated in eastern and southeastern Asia. Its fresh young leaves and buds have been consumed as a very popular nutritious vegetable in China and confirmed to display a wide variety of biological activities. To investigate the chemical constituents and their potential health benefits from the fresh young leaves and buds of , a phytochemical study on its fresh young leaves and buds was therefore undertaken.

Structural characterization, antiproliferative and anti-inflammatory activities of alkaloids from the roots of Zanthoxylum austrosinense.

Three new carbazole alkaloids, zanthoaustrones A-C (1-3), as well as nine known compounds 4-12, were isolated and characterized from the roots of Zanthoxylum austrosinense Huang (Rutaceae). Their chemical structures were elucidated on the basis of extensive and comprehensive spectroscopic methods, while the known alkaloids were identified by the comparison of their observed spectroscopic data including NMR data, MS data and optical rotation values with the data described in the literature. Furthermore, the antiproliferative activities as well as the anti-inflammatory effects of all isolated alkaloids in vitro were evaluated.

Prenylated Chromones from the Fruits of and Their Potential Anti-HIV-1 Activities.

(jack tree) is an evergreen fruit tree belonging to the genus (Moraceae), which is widely distributed in subtropical and tropical regions of Asia. Its fruits (jackfruit), well-known as the world's largest tree-borne fruit, are being consumed in our daily diets as a very popular tropical fruit throughout the world and have been confirmed to hold various health benefits. In this study, five new prenylated chromones, artocarheterones A-E (-), as well as seven known prenylated chromones (-) were purified and isolated from the ripe fruits of (jackfruit).

Prenylated Coumarins from the Fruits of with Potential Anti-inflammatory Effects and Anti-HIV Activities.

, usually known as Sapodilla, is a fairly slow-growing evergreen tropical tree which belongs to the genus (Sapotaceae), indigenous to Central America, southern Mexico, and the Caribbean. The ripe fruits of have been widely consumed as an uniquely flavored tropical fruit and verified to hold a variety of health benefits. In order to investigate the potential health-promoting chemical compositions from the fruits of cultivated in Hainan Island of China, a systematic and in-depth phytochemical study on this fruit was accordingly implemented.

Geranylated carbazole alkaloids with potential neuroprotective activities from the stems and leaves of Clausena lansium.

Clausena lansium (Lour.) Skeels is an evergreen small tree or shrub with great economic value, which belongs to the genus Clausena of the Rutaceae family. C.

Neuroprotective carbazole alkaloids from the stems and leaves of .

The investigation on the stems and leaves of led to the isolation of a previously undescribed carbazole alkaloid, clausenalenine A (), along with seven known analogues (-). The structure of was elucidated based on comprehensive spectroscopic analyses and the known compounds were identified by comparisons with data reported in the literatures. All known compounds (-) were isolated from for the first time.

[Chemical constituents from stems and leaves of Clausena emarginata].

The chemical constituents from the stems and leaves of Clausena emarginata were separated and purified by column chromatographies on silica gel,ODS,Sephadex LH-20,and PR-HPLC. The structures of the isolated compounds were identified on the basis of physicochemical properties and spectroscopic analysis,as well as comparisons with the data reported in the literature. Sixteen compounds were isolated from the 90% ethanol extract of the stems and leaves of C.

Carbazole Alkaloids with Potential Neuroprotective Activities from the Fruits of Clausena lansium.

Clausena lansium, also known as wampee, is a species of strongly scented evergreen trees belonging to the genus Clausena (Rutaceae), which is native to southern China. Its ripe fruits have been consumed as a very popular fruit and reported to possess a range of biological activities. To study the potential health-promoting constituents from the fruits of C.