Publications by authors named "Jia-jie Zhai"
Objective: To evaluate preliminary clinical outcome of Boston type I keratoprosthesis in ocular chemical burn patients.
Methods: Six keratoprosthesis were implanted into 6 patients of bilateral blindness. Visual acuity in these patients before the operation was light perception and all of them were unsuitable for standard penetrating corneal transplantation.
Purpose: The aim of this study was to investigate the sensitization, pharmacokinetics, and absorption of FK506 after corneal transplantation.
Methods: New Zealand albino rabbits were divided into normal and corneal transplantation groups. Each group was divided into 5 subgroups--saline, blank matrix, high-dose, medium-dose, and low-dose, respectively.
Conjugated linoleic acid (CLA) has been shown to reduce body fat mass in various experimental animals. It is valuable to identify its influence on enzymes involved in energy expenditure, apoptosis, fatty acid oxidation and lipolysis. We investigated isomer-specific effects of high dose, long treatment of CLA (75.
View Article and Find Full Text PDFPurpose: To investigate the stability of FK506 eye suspension and its pharmacokinetics in rabbit aqueous humor, as well as its distribution in eye tissues.
Methods: Sedimentation rate, flocculation value, redispersion time, rheological study, and accelerated experiment were determined for evaluating the stability of FK506 suspension. In a single-dose pharmacokinetic study, six rabbits were instilled a 25-microL drop of 0.
Background: Conjugated linoleic acid (CLA) refers to a group of positional and geometrical conjugated dienoic isomers of linoleic acid. Our aim was to investigate the effect of 8-week dietary CLA supplementation on blood pressure, concentrations of plasma adiponecin, leptin, and as well as angiotensin-converting enzyme (ACE) activity in obese hypertensive subjects.
Methods: Eighty obese individuals with stage 1 uncontrolled essential hypertension were randomized in a double-blind, placebo-controlled trial.
Determination of tacrolimus in rabbit aqueous humor by liquid chromatography-electrospray ionization tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
June 2008
Article Synopsis
- A new liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was created to measure tacrolimus levels in rabbit eye fluid.
- * The technique involves a simple protein-precipitation process and uses a specific column and mobile phase for separation and detection.
- * The method has been thoroughly validated, showing high accuracy and precision, and was successfully used in pharmacokinetic studies of tacrolimus in rabbits.