Publications by authors named "Jia-di Wu"
Irreversible electroporation (IRE) is a local ablative treatment for patients with pancreatic cancer. During the IRE procedure, high-intensity electric pulses are released intratumorally to disrupt plasma membranes and induce cell death. Since the intensity of the pulsed electric field (PEF) can be decreased by the tumor microenvironment, some cancer cells are subjected to a sublethal PEF and may survive to cause tumor recurrence later.
View Article and Find Full Text PDFPulmonary arterioplasty with an autologous pericardial patch helps avoid having to perform pneumonectomy in patients with locally advanced non-small cell lung cancer. However, a minimally invasive procedure for this technique has rarely been reported because the patch usually shrinks and recoils after retrieval, complicating the suturing procedure. We describe our experience with performing autologous pericardial patch arterioplasty without glutaraldehyde fixation using video-assisted thoracoscopic surgery in a patient who received neoadjuvant immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Neoadjuvant immunotherapy combined with chemotherapy improves outcomes for patients with resectable non-small-cell lung cancer (NSCLC), and the SACTION01 trial investigates the potential enhancement of this approach by adding stereotactic body radiotherapy (SBRT).
- In this phase 2 trial, 46 patients received SBRT followed by immunochemotherapy, resulting in a major pathological response (MPR) in 76% of participants, with some experiencing significant adverse effects, primarily alopecia and neutropenia.
- The study indicates that preoperative SBRT alongside immunochemotherapy is a viable treatment strategy, although it carries risks for severe adverse events, which need careful management.
Article Synopsis
- This study updates previous analyses on the use of TPF chemotherapy followed by surgery for patients with borderline resectable esophageal squamous cell carcinoma (BR-ESCC).
- It reports on a phase 2 clinical trial involving 47 patients, with 57.4% undergoing surgery and a median overall survival (OS) of 41.9 months.
- The findings support the effectiveness of TPF chemotherapy followed by surgery, showing a 3-year survival rate of 54.4% overall and 65.4% for patients who had successful R0 resection.
Background: Lymph node dissection (LND) is crucial procedure during radical resection of non-small cell lung cancer (NSCLC), but the prognostic value of L4 LND remains elusive. To investigate the prognostic value of L4 LND in patients with left-side NSCLC who underwent video-assisted thoracoscopic surgery (VATS).
Methods: Three hundred twelve patients who underwent VATS between Jan.