Publications by authors named "Jia-Zeng Xia"
Article Synopsis
- Long non-coding RNAs (lncRNAs) are over 200 nucleotides long and have been found to play a significant role in cancer by influencing processes like cell death, growth, and the spread of cancer cells.
- Research has shown that autophagy, the body's way of removing damaged cells and proteins, can have both protective and harmful effects in cancer scenarios, particularly when lncRNA expression is not regulated properly.
- The manuscript emphasizes the need to understand how lncRNAs interact with autophagy, as this relationship could have important implications for cancer treatment and research.
Article Synopsis
- Researchers are studying treatment options for gastric cancer patients with para-aortic lymph node (PAN) metastasis, which is usually considered inoperable; they're focusing on cases limited to specific lymph node regions No.16a2/b1.
- The treatment plan involves a combination of preoperative therapy (nab-paclitaxel, oxaliplatin, and S-1), followed by D2 gastrectomy with PAN dissection, and then additional postoperative therapies.
- The study aims to evaluate the effectiveness of this approach through various measures, including overall survival rates, disease-free survival, and the frequency of complications.
[Role of miR-124a methylation in patients with gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
February 2011
Objective: To investigate the DNA methylation status of the promoter region within the coding gene hsa-miR-124a in human gastric cancer tissue, and examine its association with the expression of Rb and CDK6 protein and clinicopathological factors.
Methods: Methylation-specific PCR (MS-PCR) was used to detect the DNA methylation status of hsa-miR-124a in gastric cancer tissues and adjacent normal tissues from 30 patients. The expression of Rb and CDK6 protein within these tissues was examined using immunohistochemistry.