Publications by authors named "Jia-Yun Lv"
Article Synopsis
- PFAS (per- and polyfluoroalkyl substances) have been linked to changes in kidney function, particularly through alterations in lipid metabolism, but their overall impact on kidney function and underlying mechanisms is still not well understood.
- This study examined 278 males from a community, measuring blood PFAS levels and kidney function indicators, while detecting 332 lipid molecules to investigate associations between PFAS mixtures and kidney function metrics.
- Key findings showed that higher levels of PFAS, specifically PFOA, were associated with increased uric acid levels but did not affect glomerular filtration rates; certain lipid subclasses were identified as mediators in this relationship, shedding light on the renal toxicity of PFAS.
Background: Previous studies have separately linked either perfluoroalkyl acid (PFAA) or heavy metal exposure with kidney dysfunction. However, the relationships of co-exposure to PFAAs and heavy metals with kidney function are still unclear.
Objectives: To explore the associations between exposure to PFAAs and heavy metals mixtures and kidney function in adults.