Publications by authors named "Jia-Yuan Yao"
Article Synopsis
- - Cocaine abuse disrupts the blood-brain barrier (BBB) by decreasing the expression of glucose transporter 1 (GLUT1) in brain cells, which leads to cognitive issues and increased BBB leakage.
- - The study reveals that cocaine elevates the level of miR-320a, which then reduces GLUT1 expression through the activation of the beta 2-adrenergic receptor (ADRB2).
- - Melatonin can help counteract cocaine-induced BBB disruption and cognitive impairment by boosting GLUT1 expression through a specific signaling pathway, suggesting it could be a potential treatment for cocaine-related problems.
Article Synopsis
- - Huntington's disease (HD) is caused by a mutation in the huntingtin gene, leading to a harmful version of the huntingtin protein that affects brain function, and there are currently no effective treatments available.
- - Researchers are exploring therapies that specifically target and reduce the harmful mutant huntingtin protein (mHTT) without affecting the healthy version (wild-type HTT).
- - The review highlights various approaches to selectively lower mHTT levels by focusing on its DNA and RNA, and discusses recent research findings and challenges in developing these treatments.
Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis.
BMC Med Genomics
November 2023
Background: The pathogenesis of rheumatoid arthritis (RA) is an immune imbalance, in which various inflammatory immune cells and pro-inflammatory factors are involved. Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, has been found to have increased expression in the joints of patients with RA compared to healthy individuals. However, the causal relationship between the expression level of IL-17 or IL-17 receptor (IL-17R) and RA remained unknown.
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