Assessing the Genetic Causal Effects Between Blood Metabolites and Spinal Pain: A Bidirectional Two-Sample Mendelian Randomization Study.

Background: Previous metabolomics studies have indicated a close association between blood metabolites and pain. However, the causal relationship between blood metabolites and spinal pain (SP) remains unclear. This study employs a bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between 452 blood metabolites and SP.

PEG-SeNPs as therapeutic agents inhibiting apoptosis and inflammation of cells infected with H1N1 influenza A virus.

The rapid variation of influenza challenges vaccines and treatments, which makes an urgent task to develop the high-efficiency and low-toxicity new anti-influenza virus drugs. Selenium is one of the essential trace elements for the human body that possesses a good antiviral activity. In this study, we assessed anti-influenza A virus (H1N1) activity of polyethylene glycol (PEG)-modified gray selenium nanoparticles (PEG-SeNPs) on Madin-Darby Canine Kidney (MDCK) cells in vitro.

Active Constituents with Tyrosinase Inhibitory Activities from Waste Tobacco Leaves.

One novel compound, (R)-3, 6-diethoxy-4-hydroxycyclohex-3-en-1-one (1) and thirteen known compounds were isolated from the waste tobacco leaves. The structures of two compounds (1-2) were confirmed and attributed firstly by the extensive spectroscopic data, including 1D/2D NMR, IR, HR-ESI-MS, CD, and ECD spectra. Notably, seven compounds (2, 3, 9, 10, 11, 12, and 13) exhibited better tyrosinase inhibitory activity than the positive control kojic acid.

Prevalence and Predictors of Hemorrhagic Foci on Long-term Follow-up MRI of Recent Single Subcortical Infarcts.

Hemorrhagic foci surrounding the lacune in the long-term evolution of recent single subcortical infarcts (RSSIs) remains largely unexplored. We aimed to determine the prevalence, characteristics, and predictors of hemorrhagic foci in patients with RSSI. From a prospective, longitudinal study of RSSIs, we recruited patients who underwent multimodal MRI assessments both at baseline and approximately one year after the stroke onset.

[Feasibility of Single-Breath-Hold Compressed Sensing Real-Time Cine Imaging for Assessment of Ventricular Function and Left Ventricular Strain in Cardiac Magnetic Resonance].

Objective: To explore the feasibility of single-breath-hold compressed sensing real-time cine imaging (CS-cine) in the assessment of ventricular function and left ventricular (LV) strain.

Methods: A total of 70 subjects were enrolled prospectively, and all subjects underwent cardiac magnetic resonance imaging (cardiac MRI) using both the standard steady-state free procession cine (sta-cine) acquisition and a prototype CS-cine sequence. For both CS-cine and sta-cine imaging, continuous short-axis cine images were acquired from the base to the apex to cover the entire left ventricle, and long-axis cine images including two-, three-, and four-chamber views were also acquired.

Cognitive impairment in two subtypes of a single subcortical infarction.

Background: Single subcortical infarction (SSI) is caused by two main etiological subtypes, which are branch atheromatous disease (BAD) and cerebral small vessel disease (CSVD)-related SSI. We applied the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ), the Shape Trail Test (STT), and the Stroop Color and Word Test (SCWT) to investigate the differences in cognitive performance between these two subtypes of SSI.

Methods: Patients with acute SSIs were prospectively enrolled.

Author Correction: Distribution pattern of leftventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

[Characteristics of CMR Appearance in a Case of Cardiac Metastatic Melanoma].

A 53-year-old woman was found "an occupant in the left ciliary body" two years ago and underwent the surgery of "left eye ball removal". Pathological results confirmed the diagnosis of malignant melanoma. The patient was admitted to our hospital again due to newly found heart murmur.

Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping.

Background: Peripartum cardiomyopathy (PPCM) is rare and potentially life-threatening; its etiology remains unclear. Imaging characteristics on cardiovascular magnetic resonance (CMR) and their prognostic significance have rarely been studied. We sought to determine CMR's prognostic value in PPCM by using T1 and T2 mapping techniques.

[Cardiac Magnetic Resonance Imaging Study of Ventricular Myocardial Deformation in Spontaneous T2DM Rhesus Monkey].

Objective: To assess biventricular, especially right ventricular, function and deformationin rhesus monkeys with spontaneous type 2 diabetes mellitus (T2DM) using cardiac magnetic resonance (CMR).

Methods: Twelve male spontaneous T2DM rhesus monkeys and age, sex, body mass matched 9 healthy rhesus monkeys without hypertension and myocardial infarction were included in this study. Fasting blood glucose (FPG), glycated hemoglobin (HbA1c) and blood liquid levels were measured.

[Myocardial Magnetic Resonance Texture Characteristics of Healthy Volunteers].

Objective: To determine the myocardial texture features of cardiac magnetic resonance (CMR) in healthy adult Han populations.

Methods: 59 healthy Han volunteers were recruited for this study from May 2016 to November 2017. CMR examinations were performed on the participants with a 3.

[Application Value of Motion-correction Phase Sensitive Inversion Recovery (MOCO-PSIR) to Evaluate Myocardial Fibrosis in Patients with Heart Failure Caused by Dilated Cardiomyopathy].

Objective: To study the application value of motion-correction phase sensitive inversion recovery (MOCO-PSIR) to evaluate myocardial fibrosis in the patients with heart failure caused by dilated cardiomyopathy (DCM).

Methods: A prospective study included 60 patients who underwent cardiac MRI enhanced scan from June 2017 to November 2018, including 38 patients who were clinically diagnosed with DCM and 22 patients in the normal control group. All patients were scanned with three late gadolinium enhancement (LGE) sequences: segmented-PSIR, single-shot-PSIR, MOCO-PSIR at the same time.

[Evaluating Cardiac Function of Tree Shrew (Tupaiabelangeri) using CMR at 7T with 2D Tissue Tracking].

Objective: To determine the potential value of the two-dimensional (2D) cardiac magnetic resonance imaging (CMR) tissue tracking (CMR-TT) method in assessing the cardiac function of tree shrew at 7T.

Methods: Healthy adult tree shrews (male, =8) and spraguedawley rats(male, =8) were selected for this study. CMR was performed to acquire the short-axis images of left ventricle at 7T using the same appropriative coil and cine sequence for all experimental animals.

[Magnetic Resonance Imaging Tissue Feature Tracking for Cardiac Amyloidosis].

Objective: To detect cardiac amyloidosis (CA) using cardiac magnetic resonance feature tracking(CMR-FT).

Methods: Forty-three CA patients and 24 healthy volunteers underwent steady-state free precession cine sequence on 3.0T MRI after injection of Magnevist.

Cardiovascular magnetic resonance evidence of myocardial fibrosis and its clinical significance in adolescent and adult patients with Ebstein's anomaly.

Background: Myocardial fibrosis is a common pathophysiological process that is related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial fibrosis in Ebstein's anomaly have not been fully investigated. This study aimed to evaluate myocardial fibrosis using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques, and to explore the significance of myocardial fibrosis in adolescent and adult patients with Ebstein's anomaly.

[Analysis of schistosomiasis endemic status of national surveillance sites in Yunnan Province, 2016].

Objective: To master the prevalence status of schistosomiasis in Yunnan Province in 2016, so as to provide the evidence for formulating the control strategy and intervention measures.

Methods: The schistosomiasis heavy-endemic villages were selected from each of 18 endemic counties as the survey sites. Then, the serological and etiological tests were carried out in the local residents and floating population, and the infection status of the livestock, field feces and snails were surveyed.

[Reference Values for Left Ventricular Myocardial Strains Measured by Feature-tracking Magnetic Resonance Imaging in Chinese Han Population].

Objectives: To establish reference values for left ventricular (LV) myocardial strains in a cohort of healthy Chinese volunteers with feature tracking cardiac magnetic resonance imaging.

Methods: A total of 60 healthy volunteers were recruited, receiving a cardiac magnetic resonance imaging (CMR) examination at 3.0T scanner (Tim Trio, Magnetum, Siemens, Germany).

[Clinical Application of Cardiac Magnetic Resonance Imaging in a Tertiary Referral Hospital in China].

Objectives: To review clinical application of cardiac magnetic resonace (CMR) imaging in a tertiary hospital.

Methods: A total of 344 medical records were reviewed in relation to the use of CMR imaging over one year period in a tertiary hospital in China. Data regarding indications for CMR imaging, cardiac structure and function, late gadolinium enhancement (LGE), and diagnoses made from CMR imaging were extracted and examined.

Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.

The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled.

More than valve repair: Effect of cone reconstruction on right ventricular geometry and function in patients with Ebstein anomaly.

Background: Cone reconstruction is a novel surgical procedure for tricuspid valve repair in Ebstein anomaly. This study examined the effect of cone reconstruction on right ventricle (RV) geometry, function, and synchronization.

Methods: Twenty-one patients (4-49 year-old) underwent cone reconstruction were enrolled, and matched with healthy individuals.

[Molluscicidal effect of 5% powder of niclosamide ethanolamine salt granules (NEG) in field of mountainous areas in Yunnan Province].

Objective: To evaluate the molluscicidal effect of 5% powder of niclosamide ethanolamine salt granules (NEG) in the field of mountainous areas in Yunnan Province.

Methods: The grasslands with Oncomelania hupensis snail habitats were chosen in Beideng Village, Heqing County, Yunnan Province, and were divided into 7 groups (groups of NEG 30 g/m2, NEG 40 g/m2, NEG 50 g/m2, NEG 40 g/m2 plus obstacle clearing, 50% niclosamide ethanolamine salt wettable powder (WPN) 6 g/m2, WPN 6 g/m2 plus obstacle clearing, and fresh water). The snail death rates and the densities of living snails were investigated and the results were compared in the different groups 7 d, 15 d, and 30 d after the implementation.

[Evaluation of effectiveness of comprehensive schistosomiasis control project in Yunnan Province from 2004 to 2013].

Objectives: To evaluate the effect of comprehensive schistosomiasis control project in Yunnan Province after its implementation for ten years, so as to provide the evidence for formulating the future prevention and control strategy.

Methods: The data of the schistosomiasis comprehensive control project and the endemic situation were collected and analyzed to evaluate the control effect of the project in Yunnan Province from 2004 to 2013.

Results: After the comprehensive control project implementation for ten years, the Oncomelania hupensis snail area in Yunnan Province decreased from 4,364.

[Comparison of Quantification of Myocardial Infarct Size by One Breath Hold Single Shot PSIR Sequence and Segmented FLASH-PSIR Sequence at 3. 0 Tesla MR].

Objective: To compare the two sequences [single shot true-FISP-PSIR (single shot-PSIR) and segmented-turbo-FLASH-PSIR (segmented-PSIR)] in the value of quantification for myocardial infarct size at 3. 0 tesla MRI.

Methods: 38 patients with clinical confirmed myocardial infarction were served a comprehensive gadonilium cardiac MRI at 3.