Publications by authors named "Jia-Yu Jin"
Article Synopsis
- MRG15 is a crucial gene found on chromosome 15 in mammals, involved in key cellular processes like DNA repair, cell growth, and aging by regulating gene activity through interactions with specific protein complexes.
- It not only plays a role in gene regulation but also affects liver fat metabolism and can inhibit cancer progression.
- The structure of MRG15, including its distinct N-terminal chromodomain and C-terminal domain, helps it interact with various cofactors, indicating the need for further research to understand its diverse functions in different cell types.
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy, ensuring a strict control over the intricate process of cellular and organ dynamics in heart. Various posttranslational modifications (PTMs) of Drp1 have been identified including phosphorylation, SUMOylation, palmitoylation, ubiquitination, S-nitrosylation, and O-GlcNAcylation, which implicate a role in the regulation of mitochondrial dynamics.
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