Publications by authors named "Jia-Yin Guo"
Article Synopsis
- Acetaminophen (APAP) overdose can lead to acute liver injury (ALI), and current treatments for this condition are limited; however, astilbin, a compound from Smilax glabra with antioxidant properties, shows promise in protecting against ALI.
- In a study with mice, astilbin was administered prior to APAP exposure, and the results indicated that it helped reduce ALI by altering gut microbiota and increasing beneficial metabolites like hydroxytyrosol.
- Further analysis revealed that hydroxytyrosol also provided protective effects by reducing oxidative stress and inflammation in the liver, demonstrating that astilbin promotes liver health through its interaction with gut microbes and metabolites.
Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. We previously showed that the flexible linkers of URAT1 inhibitors could enhance their potency. In this study we designed and synthesized CDER167, a novel RDEA3710 analogue, by introducing a linker (methylene) between the naphthalene and pyridine rings to increase flexibility, and characterized its pharmacological and pharmacokinetics properties in vitro and in vivo.
View Article and Find Full Text PDFThionamides have been extensively used to treat patients with hyperthyroidism worldwide. Recent pharmacovigilance studies have revealed a safety signal between carbimazole or methimazole and pancreatitis. The associated risk remains unclear.
View Article and Find Full Text PDFBackground: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder with unknown etiology. Evidence revealed that dipeptidyl peptidase IV inhibitors (DPP4i) may increase the associated risk. This study aimed to evaluate the relationship of BP with the administration of DPP4i and other risk factors in patients with type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDFUrinary Metabolomics Study of the Intervention Effect of Hypoglycemic Decoction on Type 2 Diabetes Mellitus Rats Model.
Evid Based Complement Alternat Med
October 2019
The hypoglycemic decoction (HD) is a traditional Chinese medicine (TCM) preparation for the treatment of diabetes mellitus (DM), with a remarkable therapeutic effect. However, its mechanism of action is still unclear at the metabolic level. In this study, the biochemical markers from type 2 DM (T2DM) rats, induced by a high-sugar and high-fat diet combined with streptozotocin (STZ), were detected.
View Article and Find Full Text PDF[Assessment and application of a molecular diagnostic method on the detection of four types of diarrheagenic Escherichia coli].
Zhonghua Liu Xing Bing Xue Za Zhi
June 2013
Objective: To establish and evaluate a molecular diagnostic method for routine monitoring of four types of diarrheagenic Escherichia (E.) coli (DEC)and to study the distribution of four types of DEC isolated from diarrheal patients in Shanghai.
Methods: DEC-PCR standard operation procedure(SOP)had been developed for DEC detection and isolation, using the Statens Serum Institute (SSI) DEC PCR kits with multiplex PCR technique after verification tests on reference strains.