Effects of antibiotics on the anti-tumor efficacy of immune checkpoint inhibitor therapy.

Purpose: Immunotherapy using immune checkpoint inhibitors (ICIs) has shown several benefits over traditional therapies. However, the eligible population remains small. Antibiotic (ATB) use might reduce immunotherapy efficacy by disrupting the gut microbiota.

Corrigendum to "miR-1-Mediated Induction of Cardiogenesis in Mesenchymal Stem Cells via Downregulation of Hes-1".

[This corrects the article DOI: 10.1155/2013/216286.].

miR-1-mediated induction of cardiogenesis in mesenchymal stem cells via downregulation of Hes-1.

MicroRNAs (miRNAs, miRs) have the potential to control stem cells fate decisions. The cardiac- and skeletal-muscle-specific miRNA, miR-1, can regulate embryonic stem cells differentiation to cardiac lineage by suppressing gene expression of alternative lineages. Accordingly, we hypothesized that overexpression of miR-1 may also promote cardiac gene expression in mesenchymal stem cells.

Intracellular heat shock protein 70: a possible therapeutic target for preventing postoperative atrial fibrillation.

Postoperative atrial fibrillation is a frequent complication after cardiac surgery, associated with an increased risk of mortality and morbidity; thus, additional treatment and increasing costs of postoperative care are required. Inflammation and oxidative stress caused by ischemia-reperfusion during cardiac surgery may play an important role in the pathogenesis of postoperative atrial fibrillation. Stress-inducible heat shock proteins act as molecular chaperones that maintain cell homeostasis against stress in these events.