Publications by authors named "Jia-Yi Lv"
Objectives: To evaluate the ability of sphericity in glioblastomas (GBMs) for predicting overall survival (OS) and the survival benefit from gross tumour resection (GTR).
Methods: Preoperative MRI scans were retrospectively analysed in IDH-wildtype GBM patients from two datasets. After MRI preprocessing and tumour segmentation, tumour sphericity was calculated based on the tumour core region.
Article Synopsis
- Adequate stabilization of protein-based biopharmaceuticals is crucial for their durability during manufacturing and storage, and the choice of excipients like histidine plays a key role in this process.
- Histidine, an essential amino acid, is valued for its unique physicochemical properties that allow it to serve multiple functions such as a buffering agent, stabilizer, and antioxidant in formulations.
- This review provides insight into the use of histidine in the biopharmaceutical industry, detailing its benefits, commercial applications, and interactions with proteins, ultimately highlighting both its potential and challenges in formulation strategies.
Purpose: There has been much controversy over the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) on patients with renal dysfunction. The purpose of this study was to summarize the evidence regarding the effect of ACEIs/ARBs administration on mortality in patients with nondialysis-dependent chronic kidney disease (CKD) by using a meta-analytic approach.
Methods: We searched the PubMed, Embase, and Web of Science databases for studies on the effect of ACEIs/ARBs administration on mortality in patients with nondialysis-dependent CKD published before March 2015.