[Effect of tianma gouteng decoction on the endothelial function and the renal protein expression in spontaneously hypertensive rats].

Ojective: To observe the effect of tianma gouteng decoction (TGD) on the endothelial function and the renal protein expression of spontaneously hypertensive rats, and to analyze its possible mechanism.

Methods: Totally 18 6-week-old SHR were randomly divided into 3 groups according to randomized block design, the SHR control group, the TGD group, and the captopril group, 6 in each group. Meanwhile, Wistar Kyoto (WKY) rats of the same age were recruited as a WKY control group.

[Analysis of renal protein expressions of spontaneously hypertensive rat intervention by three different Chinese medicine compounds for hypertension].

Objective: To observe the differential protein expression profile of three different Chinese medicine compounds on spontaneous hypertensive rat, which were Banxiabaizhutianma Decoction, Dihuangyinzi Decoction and Tianmagouteng Decoction, and to elaborate their function characters and regulation pathway using the principal component analysis and analyze the basic theory of different treatment of hypertension.

Methods: Give three compounds to 6-week-old SHR (Spontaneous hypertensive rat) as experimental group and captopril to 6-week-old WKY (Wistar-Kyoto rat) as control group by gavage. Monitor the blood pressure of rat tail to 24-week-old and then all rats were decapitated.

[The effect of Banxia Baizhu Tianma decoction on renal protein expression in spontaneously hypertensive rats].

Objective: To study the effect of Banxia Baizhu decoction on the spontaneously hypertensive rats and its possible mechanism.

Methods: Male SHRs of 6 weeks old were randomly and equally divided into two groups, the control SHR group and the group treated with BXBZTMD, the treated group were treated with BXBZTMD orally for 18 weeks, the control SHR group and normotensive WKY group were fed with the same amount of distilled water. Rats' blood pressure was measured through carotid artery catheterization, and protein of kidney tissues was analyzed by two-dimensional electrophoresis after extraction and purification.

[Effect of banxia baizhu tianma decoction on the vascular endothelial function of spontaneous hypertensive rats].

Objective: To study the vascular endothelial function recovery and its mechanism of Banxia Baizhu Tianma Decoction (BBTD).

Methods: 54 SH rats were randomly divided into three groups: the blank control group, BBTD group and Captopril treatment group. BBTD (at the daily dose of 4.

[Effect of banxia baizhu tianma decoction on the left ventricular hypertrophy of hypertrophied myocardium in spontaneously hypertensive rat].

Objective: To investigate the changes in renin angiotensin system (RAS) in hypertrophied myocardium of spontaneous hypertensive rat (SHR), and the effect of Banxia Baizhu Tianma Decoction (BBTD) on the changes in haemodynamic parameters and mRNA of signaling molecules of RAS at different periods.

Methods: Fifty-four male SHRs of 6 weeks old were randomly and equally divided into three groups: the untreated control group, the test group, and the positive control group, and they were treated respectively with distilled water, BBTD and captopril by dissolving in equal volume of water administrated via gavage for 18 weeks. Besides, 18 age matched Wistar-Kyoto (WKY) rats treated with distilled water were allocated in a normal control group.

[Effect of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation].

Objective: To investigate the effects of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation (TCIPA).

Methods: MDA-MB-231 breast carcinoma was applied as inductor and the platelet aggregation were investigated by Born's method in vitro and in vivo.

Results: Saponins from the flowers of Panax notoginseng inhibited TCIPA at the dose of 120, 240, 480 mg/L respectively in vitro and in vivo.