Publications by authors named "Jia-Xing Wu"

Sphingolipids, a type of bioactive lipid, play crucial roles within cells, serving as integral components of membranes and exhibiting strong signaling properties that have potential therapeutic implications in anti-cancer treatments. However, due to the diverse group of lipids and intricate mechanisms, sphingolipids still face challenges in enhancing the efficacy of different therapy approaches. In recent decades, mass spectrometry has made significant advancements in uncovering sphingolipid biomarkers and elucidating their impact on cancer development, progression, and resistance.

View Article and Find Full Text PDF

Functional disorder of the placenta is the principal cause of fetal growth restriction (FGR), usually cured with suitable clinical treatment and good nursing. However, some FGR mothers still give birth to small for gestational age (SGA) babies after treatment. The ineffectiveness of treatment in such a group of patients confused physicians of obstetrics and gynecology.

View Article and Find Full Text PDF

Background: The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the most effective temozolomide chemoradiotherapy (RT/TMZ) regimen can only slightly extend survival. How to improve RT/TMZ efficacy remains a major challenge in clinic.

Methods: Syngeneic G422-GBM model mice were subject to RT/TMZ, surgery, piperlongumine (PL), αPD1, glutathione.

View Article and Find Full Text PDF

Fetal growth restriction (FGR) is a common pregnancy complication and a risk factor for infant death. Most patients with FGR have preeclampsia, gestational diabetes mellitus, or other etiologies, making it difficult to determine the specific molecular mechanisms underlying FGR. In this study, an integrated analysis was performed using gene expression profiles obtained from Gene Expression Omnibus.

View Article and Find Full Text PDF

Industry foundation classes (IFC) is an open and neutral data format specification for building information modeling (BIM) that plays a crucial role in facilitating interoperability. With increases in web-based BIM applications, there is an urgent need for fast loading large IFC models on a web browser. However, the task of fully loading large IFC models typically consumes a large amount of memory of a web browser or even crashes the browser, and this significantly limits further BIM applications.

View Article and Find Full Text PDF