Three-dimensional location approach with silk thread guided hepatectomy for liver tumor.

Background: Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors. Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present, but the technical barriers limit their promotion.

Aim: To evaluate the value of the three-dimensional location approach with silk thread (3D-LAST) in precise resection of liver tumors.

Explore the key targets and mechanism of Danggui Buxue decoction against ulcerative colitis: Network pharmacology and experimental validation.

Ethnopharmacological Relevance: The traditional Chinese herbal formula, Danggui Buxue decoction (DBD), is known for its ability in tonifying Qi and promoting the production of blood. It is extensively utilized in treating menstrual anemia and chronic non-healing ulcers. Whereas the impact of DBD on ulcerative colitis (UC) has not been explored, and its therapeutic mechanisms are not well comprehended.

Prevalence of poor sleep quality among stroke survivors: A meta-analysis and systematic review.

Background: Poor sleep quality is common among stroke survivors, but the prevalence rates vary between studies. This meta-analysis examined the global prevalence of poor sleep quality and its moderating factors among stroke survivors.

Method: Relevant publications were systematically searched in PubMed, Web of Science, Embase, PsycINFO, CNKI and WanFang.

Nickel-Catalyzed Decarbonylation of Aromatic Carboxylic Acids with P(O)-H Compounds to Form C-P Bonds.

A novel strategy for C-P bond formation has been developed. The reaction employed aromatic carboxylic acids as the source of aromatic groups to couple with three types of P(O)-H compounds without the need to isolate intermediates, thereby achieving a one-pot construction of carbon-phosphorus bonds. The protocol demonstrated excellent applicability and functional group tolerance, enabling the production of Ar-P(O)R and Ar-PPh with moderate to excellent yields.

From Cell Clones to Recombinant Protein Product Heterogeneity in Chinese Hamster Ovary Cell Systems.

Chinese hamster ovary (CHO) cells are commonly used to produce recombinant therapeutic proteins (RTPs). The yield of RTPs in CHO cells has been greatly improved through cell editing and optimization of culture media, cell culture processes, and expression vectors. However, the heterogeneity of cell clones and product aggregation considerably affect the yield and quality of RTPs.

Molecular Phylogeny and Morphology Reveal Four New Species of (Bolbitiaceae, Agaricales) from the Qinghai-Xizang Plateau, China.

The Qinghai-Xizang Plateau, known for its high altitude, geological history of plate collision, crustal uplift, and special ecology factors, provides an ideal environment for studying fungal biodiversity in extreme environmental conditions. Some species within the , containing secondary metabolites such as psilocybin, phallotoxins, and amatoxins, have potential medicinal value for treating psychiatric disorders and for use in drug development. This study investigates (Bolbitiaceae, Agaricales) on the Plateau, based on specimens collected over the past decade, using morphological and molecular phylogenetic analyses.

Could physical activity promote indicators of physical and psychological health among children and adolescents? An umbrella review of meta-analyses of randomized controlled trials.

Background: We performed an umbrella review to synthesize evidence on the effects of physical activity (PA) interventions on indicators of physical and psychological health among children and adolescents, including body mass index (BMI), blood pressure (BP), depressive symptoms, and cognitive function.

Methods: PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched from inception through 31 July 2023. We included meta-analyses of randomized controlled trials exploring the effects of PA interventions on BMI, BP, depressive symptoms, or cognitive function in healthy or general children and adolescents.

Current status of drug therapy for chronic hepatitis B.

In this editorial, we comment on the article by Meng . Chronic hepatitis B (CHB) is a significant global health problem, particularly in developing countries. Hepatitis B virus (HBV) infection is one of the most important risk factors for cirrhosis and hepatocellular carcinoma.

Bisphenol S induced endothelial dysfunction via mitochondrial pathway in the vascular endothelial cells, and detoxification effect of albumin binding.

As a replacement of bisphenol A, bisphenol S (BPS) is commonly used in the wrappers and food containers of daily life. Epidemiological studies demonstrate a close link between BPS exposure and vascular diseases, where the biological activities of BPS remain scarcely known. Herein, the effects of BPS on endothelial function as well as the underlying mechanism were investigated in human umbilical vein endothelial cells (HUVECs) and mouse arteries.

Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets.

Heterotopic ossification (HO) refers to the abnormal formation of bone in non-skeletal tissues. Fibroblasts have traditionally been viewed as stationary cells primarily responsible for producing extracellular matrix during tissue repair and fibrosis. However, recent discoveries regarding their plasticity-encompassing roles in inflammation, extracellular matrix remodeling, and osteogenesis-highlight their potential as key contributors to the development of HO.

A Ratiometric Fluorescence Method Based on PCN-224-DABA for the Detection of Se(IV) and Fe(III).

In this study, 3,4-diaminobenzoic acid (DABA) was introduced into the porphyrin metal-organic framework (PCN-224) for the first time to prepare a ratiometric fluorescent probe (PCN-224-DABA) to quantitatively detect ferric iron (Fe(III)) and selenium (IV) (Se(IV)). The fluorescence attributed to the DABA of PCN-224-DABA at 345 nm can be selectively quenched by Fe(III) and Se(IV), but the fluorescence emission peak attributed to tetrakis (4-carboxyphenyl) porphyrin (TCPP) at 475 nm will not be disturbed. Therefore, the ratio of I/I with an excitation wavelength of 270 nm can be designed to determine Fe(III) and Se(IV).

Flexible Fiber Sensors for Real-Time Monitoring of Redox Signaling Molecules in Exercise-Mimicking Engineered Skeletal Muscle.

Real-time monitoring of reactive oxygen and nitrogen species (RONS) in skeletal muscle provides crucial insights into the cause-and-effect relationships between physical activity and health benefits. However, the dynamic production of exercise-induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components.

Association Between Biologics and Janus Kinase Inhibitors With Inflammatory Bowel Disease as Paradoxical Reactions: A Real-World Assessment.

Background And Objective: With limited evidence connecting paradoxical inflammatory bowel disease (paradoxical IBD) to the newest biologics and Janus kinase inhibitors, our study aims to investigate the occurrence of paradoxical IBD induced by these agents in treating other immune-mediated inflammatory diseases (IMIDs). We aim to identify associated risk signals, the primary affected population, and the risk profile changes over time.

Methods: We performed disproportionality analysis to evaluate paradoxical IBD risk signals using data from the FDA Adverse Event Reporting System.

Host-Guest Interactions of Metal-Organic Framework Enable Highly Conductive Quasi-Solid-State Electrolytes for Li-CO Batteries.

High-energy lithium (Li)-based batteries, especially rechargeable Li-CO batteries with CO fixation capability and high energy density, are desirable for electrified transportation and other applications. However, the challenges of poor stability, low energy efficiency, and leakage of liquid electrolytes hinder the development of Li-CO batteries. Herein, a highly conductive and stable metalorganic framework-encapsulated ionic liquid (IL@MOF) electrolyte system is developed for quasi-solid-state Li-CO batteries.

Butorphanol Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Activating Wnt/β-Catenin Signal Pathway.

Ischemic heart disease remains a global health problem with high morbidity and mortality. Butorphanol, as a novel opioid, has been discovered with its cardioprotective properties. The purpose of this study was to explore that butorphanol can alleviate hypoxia/reoxygenation (H/R)-induced myocardial injury by activating the Wnt/β-catenin signal pathway.

Exploring the structure-activity relationship of Safflower polysaccharides: From the structural characteristics to biological function and therapeutic applications.

Ethnopharmacological Relevance: Safflower, the florets of Carthamus tinctorius L., is a widely used traditional Chinese medicine for promoting circulation and improving dysmenorrhea. Polysaccharides is one of the principal water-soluble components in Safflower, which recently endowed with a variety of biological activities, thus making them have important research significance in the field of ethnopharmacology.

Ultrasound-guided percutaneous microwave ablation of primary hyperthyroidism: security and efficacy analysis.

Objectives: This study aimed to analyze the safety, efficacy, and application prospects of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperthyroidism.

Methods: Eight patients with primary hyperthyroidism who underwent ultrasound-guided glandular volume reduction between January 2021 and December 2022 were included in this study. Pre- and postablative examinations, including grayscale ultrasound, contrast-enhanced ultrasound (CEUS), laboratory examination, antithyroid drug (ATD) dosage, and quality of life (QoL) assessment via Thyroid-Specific Patient-Reported Outcome Short-Form (ThyPRO-39), were analyzed retrospectively.

A novel dual-ligand copper-based nanoflower for the colorimetric and fluorescence detection of 2,4-dichlorophenol, epinephrine and hydrogen peroxide.

Background: Nanozymes have the advantages of cost effective, simple synthesis, high durability and stability, and have been widely used in various fields. However, only a few nanomaterials with multiple enzyme-like activity have been reported, and most of the currently developed nanozymes are usually used in colorimetric or fluorescence analysis depending on a single colorimetric or fluorescence signal output. In this study, a copper-based dual-ligand biomimetic nanoflower (Cu-MN) was constructed, which demonstrated potential multiple enzyme-like activity, and was applied to the multi-mode detection of 2,4-dichlorophenol (2,4-DP), epinephrine (EP), and HO.

Construction of pyrimidine derivatives-copper enzyme mimics as colorimetric sensing elements for efficient detection of phenolic compounds and hydrogen peroxide.

As concerns about environmental pollution grow, the rapid identification and quantification of pollutants have become increasingly vital. In this work, a series of pyrimidine derivatives-Cu enzyme mimics (Cytosine-Cu, Cytidine-Cu, and CMP-Cu) with laccase- and peroxidase-like activity were prepared through the coordination of Cu with different pyrimidine derivatives (PDs). The PDs-Cu enzyme mimics contain high levels of Cu and N - Cu coordination structures, which provide sufficient catalytic sites for the substrates.

Cimicifuga heracleifolia kom. Attenuates ulcerative colitis through the PI3K/AKT/NF-κB signaling pathway.

Ethnopharmacological Relevance: Cimicifuga heracleifolia Kom. (C. heracleifolia) has demonstrated efficacy in treating gastrointestinal disorders, including splenasthenic diarrhea.

Dual Metallosalen-Based Covalent Organic Frameworks for Artificial Photosynthetic Diluted CO Reduction.

Directly converting CO in flue gas using artificial photosynthetic technology represents a promising green approach for CO resource utilization. However, it remains a great challenge to achieve efficient reduction of CO from flue gas due to the decreased activity of photocatalysts in diluted CO atmosphere. Herein, we designed and synthesized a series of dual metallosalen-based covalent organic frameworks (MM-Salen-COFs, M: Zn, Ni, Cu) for artificial photosynthetic diluted CO reduction and confirmed their advantage in comparison to that of single metal M-Salen-COFs.

Copper-Catalyzed Enantioselective [4π + 2σ] Cycloaddition of Bicyclobutanes with Nitrones.

The selective construction of bridged bicyclic scaffolds has garnered increasing attention because of their extensive use as saturated bioisosteres of arene in pharmaceutical industry. However, in sharp contrast to their racemic counterparts, assembling chiral bridged bicyclic structures in an enantioselective and regioselective manner remains challenging. Herein, we describe our protocol for constructing chiral 2-oxa-3-azabicyclo[3.

ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals.

Angiotensin-converting enzyme 2 (ACE2), a crucial element of the renin-angiotensin system (RAS), metabolizes angiotensin II into Ang (1-7), which then combines with the Mas receptor (MasR) to fulfill its protective role in various diseases. Nevertheless, the involvement of ACE2 in sepsis-induced cardiomyopathy (SIC) is still unexplored. In this study, our results revealed that CLP surgery dramatically impaired cardiac function accompanied with disruption of the balance between ACE2-Ang (1-7) and ACE-Ang II axis in septic heart tissues.