Publications by authors named "Jia-Tao Xie"
Article Synopsis
- The Eaf6 protein is important for gene regulation and cell cycle control in various organisms, but its role in entomopathogenic fungi (EPF) was previously unstudied.
- Research on BbEaf6, the EPF equivalent, shows it's mainly found in the nucleus and its deletion leads to impaired conidiation and altered stress tolerance.
- The study reveals that BbEaf6 is crucial for development and virulence, affecting the fungus's ability to infect insects and interact with environmental stressors.
is a widely used entomopathogenic fungus in insect biological control applications. In this study, we investigated the role of two sirtuin homologs, BbHst3 and BbHst4, in the biological activities and pathogenicity of . Our results showed that deletion of and/or led to impaired sporulation, reduced (~50%) conidial production, and decreased tolerance to various stresses, including osmotic, oxidative, and cell wall-disturbing agents.
View Article and Find Full Text PDFSirtuins are a class of histone deacetylases that promote heterochromatin formation to repress transcription. The entomopathogenic fungus contains six sirtuin homologs. The class III histone deacetylase, BbSir2, has been previously shown to affect the regulation of carbon/nitrogen metabolism and asexual development, with only moderate effects on virulence.
View Article and Find Full Text PDFChromatin remodeling is mediated in part by post-translational acetylation/deacetylation modifications of histones. Histone acetyltransferases (HATs), e.g.
View Article and Find Full Text PDFChromatin transitions are mediated in part by acetylation/deacetylation post-translational modifications of histones. Histone deacetylases, e.g.
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