Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer.

Background: Molecular targeted drugs is now widely used in non-small cell lung cancer (NSCLC) clinical treatment. Icotinib hydrochloride is a new type of oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs). In this study, we examined the role of EGFR, K-RAS, B-RAF somatic mutations and EGFR mRNA expression in tumor specimens from advanced NSCLC patients as predicators of the efficacy of icotinib hydrochloride.

[Clinical efficacy of immediate implants restoration in anterior zone].

Purpose: To elevate the clinical efficacy of immediate loading in anterior implants.

Methods: Forty eight implants were placed in 33 patients and the implants were immediately loaded to provide support for fixed provisional prosthesis within 3-6 months. Then, metal-ceramic crowns were restored.

[Clinical study of maxillary sinus floor elevation with simultaneous placement of implants from the top of alveoli].

Purpose: To evaluate the clinical results of maxillary sinus floor elevation technique with bone condensers on implantation.

Methods: 104 patients underwent maxillary sinus floor elevation and 126 implants were inserted and restored. Clinical examination and radiographs were conducted.

Demilune cell and parotid protein from murine oviductal epithelium stimulates preimplantation embryo development.

In mammals, fertilization and early preimplantation embryo development occur in the oviduct. We hypothesized that interaction exists between the developing embryos and the maternal genital tract, such that the embryos modulate the physiology and gene expression of the oviduct so that it is conducive to their development. By comparing the gene expression patterns in mouse oviducts containing transferred preimplantation embryos with those of oviducts containing oocytes, we report here the characterization of demilune cell and parotid protein (Dcpp), which was up-regulated in the embryo-containing oviduct.

Differential growth, cell proliferation, and apoptosis of mouse embryo in various culture media and in coculture.

Sequential culture and coculture are two methods of improving the development of preimplantation embryos in vitro. Direct comparison of the efficiency of these methods is limited. Proliferation and apoptosis determine the total number of blastomere in preimplantation embryo, which is a sensitive parameter for evaluation of the development of embryo in vitro.

The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction.

The oviduct-derived embryotrophic factor, ETF-3, enhances the development of trophectoderm and the hatching process of treated embryos. Monoclonal anti-ETF-3 antibody that abolishes the embryotrophic activity of ETF-3 recognized a 115-kDa protein from the conditioned medium of immortalized human oviductal cells. Mass spectrometry analysis showed that the protein was complement C3.

[Maxillary sinus lifting and simultaneously placement of implants from the top of alveoli].

Objective: To study the effect of maxillary sinus floor elevation by the Frialit-2 Bone Condenser for implantation.

Methods: 11 patients underwent sinus floor lift by The Frialit-2 Bone Condenser and were inserted 14 implants. The time of following up was 10 - 21 months.

Coculture of human oviductal cells maintains mitochondrial function and decreases caspase activity of cleavage-stage mouse embryos.

Objective: To investigate the mitochondrial function and caspase activity in mouse embryos after human oviductal cell coculture.

Design: Experimental laboratory study.

Setting: University gynecology unit.

Early developing embryos affect the gene expression patterns in the mouse oviduct.

Fertilization and development of mouse embryos occur in the ampullae of oviduct. We hypothesize that fetal-maternal communication exists in the preimplantation period, allowing optimal development of embryos. It is known that embryotrophic factors from oviduct affect the development of embryos.