Publications by authors named "Jia-Rui Lu"
The dual inhibition of histone lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) has emerged as a promising strategy for cancer therapy. In this study, we report the discovery of novel 5-cyano-3-phenylindole-based LSD1/HDAC dual inhibitors, evaluated through both in vitro and in vivo assays. Among these inhibitors, compound was identified as particularly potent, exhibiting high inhibitory activity against LSD1 (IC = 39.
View Article and Find Full Text PDFFollicular CD8 T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model.
Biochim Biophys Acta Mol Basis Dis
October 2024
Article Synopsis
- Emerging evidence highlights the crucial role of a specific subset of CD8 T cells, called CD8CXCR5 T cells, in the development of multiple sclerosis (MS).
- These cells are found in higher numbers during the acute phase of MS and experimental models, with their presence linked to new lesions in the central nervous system and clinical severity.
- CD8CXCR5 T cells can activate B cells and boost the production of antibodies associated with the disease, suggesting they may contribute to CNS damage by increasing humoral immune responses.
A gram-staining-positive, rod-shaped bacterium, designed strain FJAT-51161 was isolated from farmland soil collected from Fujian Province, China. Growth was observed at 25-40 °C (optimum 30 °C), pH 7.0-9.
View Article and Find Full Text PDFBackground: Undifferentiated connective tissue disease (UCTD) is widely considered to be a distinct clinical entity, and now divided into two subgroups: stable UCTD and early UCTD. The most frequent onset symptoms of UCTD include arthralgias, arthritis, Raynaud's phenomenon, mucocutaneous involvement, and sicca symptoms. However, Neurologic involvement is rare, and intracranial lesion as onset symptom in a patient with early UCTD has not yet been reported.
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