Publications by authors named "Jia-Pan Sun"

Background: Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.

Methods: Sixty male Sprague-Dawley rats were used in this study.

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Objective: To investigate the protective effects of modified Linggui Zhugan Decoction (, MLZD), a traditional Chinese medicine formula, on obese type 2 diabetes mellitus (T2DM) rats.

Methods: Fifty Sprague-Dawley rats were randomly divided into 5 groups by a random number table, including normal, obese T2DM (ob-T2DM), MLZD low-dose [MLDZ-L, 4.625 g/(kg·d)], MLZD middle-dose [MLD-M, 9.

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Article Synopsis
  • The study aims to determine if berberine can enhance the endothelial repair abilities of early endothelial progenitor cells (EPCs) from prehypertensive individuals by boosting CXCR4 signaling.
  • The researchers isolated EPCs from both prehypertensive and healthy subjects and tested their reendothelialization capabilities in a mouse model, observing various signaling pathways involved in their function.
  • Results showed that berberine treatment improved CXCR4/JAK-2 signaling in EPCs, significantly enhancing their restoration capacity in vivo, suggesting berberine could be a potential preventive treatment for heart disease related to prehypertension.
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