Publications by authors named "Jia-Nan Tang"
The genome tagging project (GTP) plays a pivotal role in addressing a critical gap in the understanding of protein functions. Within this framework, we successfully generated a human influenza hemagglutinin-tagged sperm-specific protein 411 (HA-tagged Ssp411) mouse model. This model is instrumental in probing the expression and function of Ssp411.
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- * Researchers found that knocking in miR-3074-5p in pregnant mice resulted in higher levels of pro-inflammatory cytokines, more M1 macrophages, and increased embryo resorption compared to wild-type mice.
- * The findings suggest that miR-3074-5p targets estrogen receptor-α, promoting harmful immune responses and potentially contributing to implantation issues in patients with repeated implantation failure by disrupting the inflammatory balance in early pregnancy.
Cadmium is a major environmental toxicant that is released into the atmosphere, water and soil in the form of cadmium oxide, cadmium chloride, or cadmium sulfide via industrial activities, such as the manufacturing of batteries and pigments, metal smelting and refining and municipal waste incineration. In the present study, we investigated the effects of cadmium exposure on sperm quality parameters, fertilization capacity and early embryonic development. Our study showed that in vitro incubation of human or mouse sperms with cadmium for a long time (up to 24 hours) could significantly decreased sperm motility in a concentration- and time-dependent manner.
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