[Effects of Sialidase Inhibitor on Proliferation and Apoptosis of Endometrial Cancer Cells].

Objectives: To explore the effects of sialidase inhibitor on the proliferation and apoptosis of endometrial cancer Ishikawa cells.

Methods: Ishikawa cells were cultured and divided into 2 groups: control group and sialidase inhibitor N-Acetyl-2, 3-dehydro-2-deoxyneuraminic acid (DANA) treated group. After the sialidase activity was compared between the two groups, the expression level of matrix metalloproteinases (MMPs), proliferating cell nuclear antigen (PCNA), apoptosis rate and proliferation ability were detected by immunofluorescence staining, flow cytometry or MTT assay.