Mediation Effect of Oxidative Stress on Association Between Selenium Intake and Cognition in American Adults.

Objectives: Dementia affects millions of aged people globally and mainly results from oxidative stress. Selenium shows beneficial effects on dementia however it remains elusive for the mediation effect of oxidative stress on the association between selenium and cognition. The present study firstly investigated the potential mediation role of oxidative stress on the relationship of selenium and cognition.

A nonlinear association between total selenium intake and blood selenium concentration: An analysis based on the National Health and Nutrition Examination Survey 2011-2018.

Diets are the major sources of selenium (Se) and biomonitoring Se is used for the assessment of Se status. The present study explored the association between Se intake and blood Se concentration from the National Health and Nutrition Examination Survey 2011-2018 data for optimizing Se reference intakes among American adults and interpreted the data in the context of exposure guidance values. Weighted linear regression models were conducted to evaluate the association between Se intake and blood Se concentration.

Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology.

Neurological disorders are the primary cause of human disability and mortality globally, however, current medications slightly alleviate some symptoms of degenerative diseases. Serine is an important amino acid for the brain function and involved in a variety of biosynthetic pathways and signal transduction processes. The imbalance of serine metabolism is associated with neurodegeneration, including neuroinflammation, oxidative stress and apoptosis.

Jasminoidin and ursodeoxycholic acid exert synergistic effect against cerebral ischemia-reperfusion injury via Dectin-1-induced NF-κB activation pathway.

Background: Jasminoidin (JA) and ursodeoxycholic acid (UA) were shown to act synergistically against ischemic stroke (IS) in our previous studies.

Purpose: To investigate the holistic synergistic mechanism of JA and UA on cerebral ischemia.

Methods: Middle cerebral artery obstruction reperfusion (MCAO/R) mice were used to evaluate the efficacy of JA, UA, and JA combined with UA (JU) using neurological function testing and infarct volume examination.

Bioaccumulation determines the toxicity of carbon dots to two marine dinoflagellates.

With the ever-increasing application of carbon dots (CDs), a substantial amount will be released and assemble in the aquatic environment. Nevertheless, potential photodegradation of CDs in the aquatic environment, their accumulation and impacts in aquatic organisms remain unclear. Our study examined the toxicity of CDs to two marine dinoflagellates Prorocentrum micans and Prorocentrum donghaiense.

The role of traditional herbal medicine for ischemic stroke: from bench to clinic-A critical review.

Background: Ischemic stroke (IS) is a leading cause of death and severe long-term disability worldwide. Over the past few decades, considerable progress has been made in anti-ischemic therapies. However, IS remains a tremendous challenge, with favourable clinical outcomes being generally difficult to achieve from candidate drugs in preclinical phase testing.

[Research Status of Application of Gold Nanoparticles in Medical Biotechnology].

In recent years, gold nanoparticles (GNPs) have attracted more and more attention for their unique physical, chemical and biological properties, and are emerging as optical probes and biocompatibility materials for use. With the application of nanogold labeling technology in the medical field, detection techniques using GNPs as immune markers will become a major labeling technique, and will have wide applications in basic and clinical medicine. In this article, recent research progress on the applications of GNPs in the detection of pathogens, nucleic acids, and proteins and in the preparation of biosensors is reviewed.

[Seroepidemiology investigation of neutralizing antibody against enterovirus 71 among healthy people in Tianjin].

Objective: To investigate the latent infection caused by enterovirus 71 (EV71) among healthy people in Tianjin and to provide evidence on prevention and control hand-food and mouth diseases (HFMD).

Methods: 1611 sera specimens were collected from healthy people in Tianjin while EV71 antibody was detected by neutralization test, and then the results were analyzed statistically.

Results: For determining positivity, the cut-point was set at 1:4.

[Safety and immunogenicity on three lots of influenza split vaccines among adults].

Objective: To evaluate the immunogenicity, safety and stability of the manufacture process regarding three consecutive lots of influenza split vaccines (Anflu).

Methods: A double-blind, randomized and controlled clinical trial was conducted in healthy volunteers. A total of 566 subjects aged 18 to 60 years were recruited and stratified into four age groups before randomly assigned into four groups.

[An applied multilevel model used in the study on behavior of smoking].

Objective: To introduce the nature and its application of a multilevel model.

Methods: Data was analyzed from a baseline survey of smoking behavior among middle school students sponsored by a WHO smoking controll project. Multilevel analysis was used on available data and to compare the results from logistic regression.

[Multilevel model analysis on the influence of smoking among university students in Tianjin].

Objective: To study the influencing factors of smoking among university students on individual and classes level by multilevel model and to identify high risk groups in order to develop pertinent prevention measures which can decrease smoking behavior among university students.

Methods: Self-reported data on knowledge, attitude and behavior on smoking coming from a randomly clustered sampling of 24 classes in students from 12 universities in Tianjin.

Results: Through analyses of 743 questionnaires from university students, we learned that the occasional smoking rate was 10.