Exosomal circRHCG promotes breast cancer metastasis via facilitating M2 polarization through TFEB ubiquitination and degradation.

Triple-negative breast cancer (TNBC) is a highly aggressive cancer with distant metastasis. Accumulated evidence has demonstrated that exosomes are involved in TNBC metastasis. Elucidating the mechanism underlying TNBC metastasis has important clinical significance.

Integration of bioinformatics and machine learning strategies identifies APM-related gene signatures to predict clinical outcomes and therapeutic responses for breast cancer patients.

Background: Tumor antigenicity and efficiency of antigen presentation jointly influence tumor immunogenicity, which largely determines the effectiveness of immune checkpoint blockade (ICB). However, the role of altered antigen processing and presentation machinery (APM) in breast cancer (BRCA) has not been fully elucidated.

Methods: A series of bioinformatic analyses and machine learning strategies were performed to construct APM-related gene signatures to guide personalized treatment for BRCA patients.

Roles and mechanisms of miR-195-5p in human solid cancers.

Cancer persists as a worldwide disease that contributes to high morbidity and mortality rates. As a class of non-coding RNA, microRNAs (miRNAs) are one kind of important regulators in cancer and frequently implicated in tumor development and progression. Emerging experiments have suggested that miRNA-195-5p (miR-195-5p) can regulate neoplastic processes in many pathways.

Exosomal circRNAs: a new communication method in cancer.

Exosomes are extracellular vesicles with unique membrane markers and components that participate in cellular communication. The contents of exosomes, including growth factors, microRNAs, long noncoding RNAs, and circular RNAs (circRNAs), have been recognized as prognostic biomarkers and promote cancer progression through cancer cell growth, metastasis, angiogenesis, and cancer development. One of the components of exosomes, circRNAs, are covalently closed and prevented from degrading, which results in their continually accumulating in exosomes.

Void-free bonding for a large slab laser crystal.

A void-free bonding technique was demonstrated for a large slab Nd: YAG crystal with a bonding surface dimension of ∼160×70. By using the novel fluxless oxide layer removal technology, the indium-oxide barrier problem was resolved. With the help of electrochemical-polished indium solder and a plasma-cleaned heat sink, the solderability of the indium was enhanced; in particular, the contact angle of the solder was improved from 51° to 31°.

Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice.

Conditional knockout mice with targeted disruption of B-cell associated protein (BAP)31 in adult mouse liver were generated and challenged with a high-fat diet (HFD) for 36 or 96 days and markers of obesity, diabetes, and hepatic steatosis were determined. Mutant mice were indistinguishable from WT littermates, but exhibited increased HFD-induced obesity. BAP31-deletion in hepatocytes increased the expression of SREBP1C and the target genes, including acetyl-CoA carboxylase 1 and stearoyl-CoA desaturase-1, and increased hepatic lipid accumulation and HFD-induced liver steatosis.

8.2 kW high beam quality quasi-continuous-wave face-pumped Nd:YAG slab amplifier.

An 8 kW level quasi-continuous-wave (QCW) face-pumped 1064 nm slab laser with high beam quality was developed by a master oscillator power amplifier (MOPA) system. A single-mode fiber seed laser was amplified by two-stage single-pass Nd:YAG rod preamplifiers and four face-pumped Nd:YAG slab amplifiers. The slab amplifiers were well designed with uniform pumping and uniform cooling for well-distributed thermal and stress.

Preclinical assessment of the distribution, metabolism, and excretion of S-propargyl-cysteine, a novel H2S donor, in Sprague-Dawley rats.

Aim: To study the distribution, metabolism and excretion of S-propargyl-cysteine (SPRC), a novel hydrogen sulfide (H2S) donor, after oral administration in rats.

Methods: Adult Sprague-Dawley rats were used. The tissue distribution of [(35)S] SPRC-derived radioactivity was measured using a liquid scintillation counter.

High-power narrow-linewidth quasi-CW diode-pumped TEM00 1064 nm Nd:YAG ring laser.

We demonstrated a high average power, narrow-linewidth, quasi-CW diode-pumped Nd:YAG 1064 nm laser with near-diffraction-limited beam quality. A symmetrical three-mirror ring cavity with unidirectional operation elements and an etalon was employed to realize the narrow-linewidth laser output. Two highly efficient laser modules and a 90° quartz rotator for birefringence compensation were used for the high output power.

Compact high-efficiency 100-W-level diode-side-pumped Nd:YAG laser with linearly polarized TEM00 mode output.

We present a compact high-efficiency and high-average-power diode-side-pumped Nd:YAG rod laser oscillator operated with a linearly polarized fundamental mode. The oscillator resonator is based on an L-shaped convex-convex cavity with an improved module and a dual-rod configuration for birefringence compensation. Under a pump power of 344 W, a linearly polarized average output power of 101.

[Microscopic raman imaging spectra of realgar and light-induced degradation products in realgar].

Light-induced degradation in realgar was studied by means of Raman spectroscopy. The result substantiated the following reaction: An additional S atom is inserted between the As atoms in the As4S4 molecule because As--As bonds are weaker than As--S bonds. It is likely that the resulting As--S--As molecule is too unstable to exist.

[Study of poly (3,4-ethylene dioxythiophene) : poly (styrene sulfonate) by in-situ resonance Raman spectroscopy].

Poly (3,4-ethylene dioxythiophene) (PEDOT): Poly (styrene sulfonate) (PSS) has attracted a lot of interest for application in organic electronics due to good stability and high electronic conductivity in its doped state. Indeed, thin layers of PEDOT:PSS was regularly used in light emitting diodes (PLEDs) as hole injection and transportation layer. Here, Doping and dedoping states of PEDOT:PSS were studied by absorbance spectra and Raman spectra.

[The three-dimension spectral subtraction fluorescence to check adulteration of diesel oil by 120# solvent naphtha].

The characteristics of a adulterated sample of diesel oil by 120# solvent naphtha were studied with three-dimension spectral subtraction fluorescence technique, and it is shown that the technique could determine quickly whether there is a adulterated sample of 120# solvent naphtha in diesel. At the same time, by measuring the volume of three-dimension spectral subtraction fluorescence graph, the authors found that this total volume is directly related to the concentration of the adulterant present in the sample. The study is important for us to analyse whether there is a adulterated sample of 120# solvent naphtha in diesel, and is of significance for us to maintain the stability of market.

Effects of common inorganic anions on the rates of photocatalytic degradation of sodium dodecylbenzenesulfonate over illuminated titanium dioxide.

Experiments were carried out to study the effects of several anions on the photocatalytic degradation rates of sodium dodecylbenzene sulphonate (DBS) with TiO2 as catalyst. The anions were added as Na2SO4, NaNO3, NaCl, NaHCO3, NaH2PO4 and Na3PO4, and two levels of anion content, i.e.