Publications by authors named "Jia-Jun Tu"

This study aimed to examine the association between constipation and mild cognitive impairment (MCI); and further elucidate the possible mechanisms involved. A cross-sectional study was conducted among community-dwelling elders (N = 789) in Nanning, China. Trained research staffs collected detailed information through questionnaires and physical examinations.

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Aging, a complex biological process influenced by genetic, environmental, and pharmacological factors, presents a significant challenge in understanding its underlying mechanisms. In this study, we explored the divergent impacts of metformin treatment on the lifespan and healthspan of young and old C. elegans, demonstrating a intriguing "elixir in youth, poison in elder" phenomenon.

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Article Synopsis
  • Aging and age-related diseases are linked to oxidative stress and inflammation, prompting research into nonsteroidal anti-inflammatory drugs (NSAIDs) for potential lifespan extension.
  • In a study with Caenorhabditis elegans, aspirin and ibuprofen were found to extend lifespan in both young and old worms by reducing reactive oxygen species (ROS) and boosting antioxidant gene expression.
  • Conversely, acetaminophen and indomethacin worsened aging in older worms, suggesting they may pose risks rather than benefits for elderly individuals due to increased toxicity and oxidative stress.
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Objectives: Precise determination of cervical lymph node metastasis (CLNM) involvement in patients with early-stage thyroid cancer is fairly significant for identifying appropriate cervical treatment options. However, it is almost impossible to directly judge lymph node metastasis based on the imaging information of early-stage thyroid cancer patients with clinically negative lymph nodes.

Methods: Preoperative US images (BMUS and CDFI) of 1031 clinically node negative PTC patients definitively diagnosed on pathology from two independent hospitals were divided into training set, validation set, internal test set, and external test set.

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Peri-implantitis is a common complication characterized by inflammation in tissues surrounding dental implants due to plaque accumulation, which can lead to implant failure. While air flow abrasive treatment has been found to be effective for debriding implant surfaces, little is known about the factors that affect its cleaning capacity. This study systematically examined the cleaning capacity of air powder abrasive (APA) treatment with β-tricalcium phosphate (β-TCP) powder, using various powder jetting strengths and different particle sizes.

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