Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer.

Shikonin (SHK), a major component of shiverweed, was provided with anti-tumor effects via multiple targets and signal pathways. Nevertheless, the specific mechanism of its function in colorectal cancer (CRC) still needed to be further explored. The study was designed to examine the role of SHK in CRC and its specific mechanism on the cell tumor behavior of CRC.

Design of a Measurement System for Six-Degree-of-Freedom Geometric Errors of a Linear Guide of a Machine Tool.

This paper proposes a system utilizing a Renishaw XL80 positioning error measuring interferometer and sensitivity analysis design to measure six-degree-of-freedom (6 DOF) geometric errors of a machine tool's linear guide. Each error is characterized by high independence with significantly reduced crosstalk, and error calculations are extremely fast and accurate. Initially, the real light path was simulated using Zemax.

Evolution of Slow Magnetic Relaxation: from Diamagnetic Matrix Y(OH)CO3 to Dy(0.06)Y(0.94)(OH)CO3 with High Spin-Reversal Barrier and Blocking Temperature.

A stable Dy(III)-dispersed compound with single-molecule magnet behavior, Dy(0.06)Y(0.94)(OH)CO3, was isolated by a general strategy targeted at the doping of paramagnetic Dy(3+) into a diamagnetic 3D inorganic network of Y(OH)CO3.