Cervical myeloid sarcoma as an initial clinical manifestation: Four case reports.

Background: Cervical myeloid sarcoma (MS) is a rare hematological malignancy characterized by the formation of extramedullary soft tissue masses in the cervical region. Due to its uncommon presentation in the female reproductive system, cervical MS poses significant diagnostic and therapeutic challenges. Consequently, there is a pressing need for more research and clinical experience to better understand, diagnose, and manage this condition effectively.

Extremely strengthening fatigue resistance, elastic restorability and thermodynamic stability of a soft transparent self-healing network based on a dynamic molecular confinement-induced bioinspired nanostructure.

Soft self-healing materials are crucial for the development of next-generation wearable electronics that could function in dynamic environments and resist mechanical damage. However, several challenges remain, including fatigue fracture, poor elasticity, and thermodynamic lability, which significantly limit their practical applications. Here, with a model system of soft self-healing polyurea, we propose a molecular engineering strategy of transforming inherently fragile materials with an island-like structure into resilient ones with a bicontinuous nanophase separation structure using 2-ureido-4-pyrimidinone (UPy) supramolecular motifs as structural regulators.

Room-Temperature Self-Healing Soft Composite Network with Unprecedented Crack Propagation Resistance Enabled by a Supramolecular Assembled Lamellar Structure.

Soft self-healing materials are compelling candidates for stretchable devices because of their excellent compliance, extensibility, and self-restorability. However, most existing soft self-healing polymers suffer from crack propagation and irreversible fatigue failure due to easy breakage of their dynamic amorphous, low-energy polymer networks. Herein, inspired by distinct structure-property relationship of biological tissues, a supramolecular interfacial assembly strategy of preparing soft self-healing composites with unprecedented crack propagation resistance is proposed by structurally engineering preferentially aligned lamellar structures within a dynamic and superstretchable poly(urea-ureathane) matrix (which is elongated to 24 750× its original length).

Vascular smooth muscle-inspired architecture enables soft yet tough self-healing materials for durable capacitive strain-sensor.

Catastrophically mechanical failure of soft self-healing materials is unavoidable due to their inherently poor resistance to crack propagation. Here, with a model system, i.e.

Highly thermoconductive yet ultraflexible polymer composites with superior mechanical properties and autonomous self-healing functionality a binary filler strategy.

It is still a formidable challenge to develop ideal thermal dissipation materials with simultaneous high thermal conductivity, excellent mechanical softness and toughness, and spontaneous self-healing. Herein, we report the introduction of sandwich-like boron nitride nanosheets-liquid metal binary fillers into an artificial poly(urea-urethane) elastomer to address the above issue, which confers the composite elastomer with a unique thermal-mechanical-healing combination, including a low modulus, high in-plane thermal conductivity and high mass loading of rigid fillers but self-recoverability and room-temperature self-healing.

Molecular engineering of a colorless, extremely tough, superiorly self-recoverable, and healable poly(urethane-urea) elastomer for impact-resistant applications.

Polyurethane or polyurea elastomers with superb mechanical strength and toughness, good self-recoverability and healable characteristics are of key significance for practical applications. However, some mutually exclusive conflicts among these properties make it challenging to optimize them simultaneously. Herein, we report a facile strategy to fabricate a colorless healable poly(urethane-urea) elastomer with the highest reported mechanical toughness and recoverable energy dissipation capability (503.

An autonomously ultrafast self-healing, highly colourless, tear-resistant and compliant elastomer tailored for transparent electromagnetic interference shielding films integrated in flexible and optical electronics.

Considering the operation reliability of flexible and optical electronics (FOEs) in dynamic and real-world environments, autonomous self-healing electromagnetic interference (EMI) shielding materials with high transparency, good stretchability and excellent tear-resistance are urgently required but always difficult to achieve due to the poor dynamics of their elastic substrates. Herein, we propose a facile strategy to design a highly dynamic polyurea elastomer (PDMS-MPI-HDI) featuring with ultrahigh optical transparency (>94%), ultralow elastic modulus (<1 MPa), high tear-resistant stretchability (800%), and ultrafast autonomous self-healing (100 s for scratch-healing). Taking PDMS-MPI-HDI as a substrate for embedding silver nanowires (Ag NWs), the first transparent, stretchable and self-healable EMI shielding materials (Ag NWs/PDMS-MPI-HDI) are presented.

A Fast Room-Temperature Self-Healing Glassy Polyurethane.

We designed and synthesized a colorless transparent glassy polyurethane assembled using low-molecular-weight oligomers carrying a large number of loosely packed weak hydrogen bonds (H-bonds), which has a glass transition temperature (T ) up to 36.8 °C and behaves unprecedentedly robust stiffness with a tensile Young's modulus of 1.56±0.

Triple-Stimuli-Responsive Smart Nanocontainers Enhanced Self-Healing Anticorrosion Coatings for Protection of Aluminum Alloy.

Novel acid/alkali/corrosion potential triple-stimuli-responsive smart nanocontainers (TSR-SNs) were successfully assembled to regulate the release of an encapsulated corrosion inhibitor, benzotriazole (BTA), by installing specially structured bistable pseudorotaxanes as supramolecular nanovalves onto orifices of mesoporous silica nanoparticles. In normal conditions, BTA molecules were sealed in the mesopores. Upon any stimulus of acid, alkali, or corrosion potential, BTA molecules were quickly released because of the open states of the supramolecular nanovalves.

Quadruple Stimuli-Responsive Mechanized Silica Nanoparticles: A Promising Multifunctional Nanomaterial for Diverse Applications.

Novel quadruple stimuli-responsive mechanized silica nanoparticles were constructed by installation of supramolecular nanovalves onto the exterior surface of mesoporous silica nanoparticles. The release of cargo molecules is triggered by acid/Zn /alkali/reduction potential stimuli. This has potential application in the development of drug delivery systems or construction of smart anticorrosion coatings.

Dual pH-Mediated Mechanized Hollow Zirconia Nanospheres.

We demonstrate for the first time how to assemble mechanized hollow zirconia nanospheres (MHzNs), consisting of hollow mesoporous zirconia nanospheres (HMZNs) as nanoscaffolds and supramolecular switches anchored on the exterior surface of HMZNs. The remarkable advantage of substitution of HMZNs for conventional mesoporous silica nanoscaffolds is that HMZNs can suffer the hot alkaline reaction environment, which provides a novel strategy for functionalization and thus achieve dual pH-mediated controlled release functions by simple and practicable assembly procedure. Under neutral solution, cucurbituril[7] (CB[7]) macrocycles complexed with propanone bis(2-aminoethyl)ketal (PBAEK) to form [2]pseudorotaxanes as supramolecular switches, blocking the pore orifices and preventing the undesirable leakage of cargoes.

Facile Synthesis of Smart Nanocontainers as Key Components for Construction of Self-Healing Coating with Superhydrophobic Surfaces.

SiO2-imidazoline nanocomposites (SiO2-IMI) owning high loading capacity of corrosion inhibitor, 1-hexadecyl-3-methylimidazolium bromide (HMID), and a special acid/alkali dual-stimuli-accelerated release property have been synthesized via a one-step modified Stöber method. SiO2-IMI were uniformly distributed into the hydrophobic SiO2 sol to construct "host"-"guest" feedback active coating with a superhydrophobic surface (SiO2-IMI@SHSC) on aluminium alloy, AA2024, by dip-coating technique. SiO2-IMI as "guest" components have good compatibility with "host" sol-gel coating, and more importantly, once localized corrosion occurs on the surface of AA2024, SiO2-IMI can simultaneously respond to the increase in environmental pH around corrosive micro-cathodic regions and decrease in pH near micro-anodic regions, promptly releasing HMID to form a compact molecular film on the damaged surface, inhibiting corrosion spread and executing a self-healing function.

Triple-stimuli-responsive nanocontainers assembled by water-soluble pillar[5]arene-based pseudorotaxanes for controlled release.

We constructed triple-stimuli-responsive nanocontainers (T-SRNs), consisting of mesoporous silica nanoparticles for accommodating cargoes and bistable [2]pseudorotaxanes for regulating cargoes and realizing controlled release. T-SRNs eliminate premature leakage of model cargoes under neutral solution conditions by the formation of complexes of water-soluble carboxylate-substituted pillar[5]arenes (WP5) with 1,6-hexanediammonium (HDA) recognition stations to block pore orifices. After exposure to acid, alkali pH or Zn environments, T-SRNs release encapsulated cargoes promptly, which can be attributed to the dethreading of WP5 from HDA sites by different approaches and the lack of stoppers.

Voltage/pH-Driven Mechanized Silica Nanoparticles for the Multimodal Controlled Release of Drugs.

The major challenges of current drug delivery systems for combination chemotherapy focus on how to efficiently transport drugs to target sites and release multiple drugs in a programmed manner. Herein, we report a novel multidrug delivery system, MSNPs 1, based on mechanized silica nanoparticles, which were constructed through functionalization of mesoporous silica nanoparticles with the acid-cleavable intermediate linkages and the monoferrocene functionalized β-cyclodextrin (Fc-β-CD) as supramolecular nanovalves. MSNPs 1 achieved zero premature release in the physiological pH solution and realized two different release modalities.

Mono-benzimidazole functionalized β-cyclodextrins as supramolecular nanovalves for pH-triggered release of p-coumaric acid.

The self-complexation of mono-benzimidazole functionalized β-cyclodextrins was investigated. The unique molecular structure employed as supramolecular nanovalves were installed on the external surface of mesoporous silica to assemble mechanized silica nanoparticles, which showed pH-triggered release property.

Mechanized silica nanoparticles based on reversible bistable [2]pseudorotaxanes as supramolecular nanovalves for multistage pH-controlled release.

Cucurbit[6]uril-based reversible bistable [2]pseudorotaxanes were designed, synthesized and installed on the surface of mesoporous silica nanoparticles as supramolecular nanovalves. The assembled mechanized silica nanoparticles realize the multistage pH-controlled release of benzotriazole and the potential for reutilization.

Acid and alkaline dual stimuli-responsive mechanized hollow mesoporous silica nanoparticles as smart nanocontainers for intelligent anticorrosion coatings.

The present paper introduces an intelligent anticorrosion coating, based on the mechanized hollow mesoporous silica nanoparticles (HMSs) as smart nanocontainers implanted into the self-assembled nanophase particles (SNAP) coating. As the key component, smart nanocontainers assembled by installing supramolecular nanovalves in the form of the bistable pseudorotaxanes on the external surface of HMSs realize pH-responsive controlled release for corrosion inhibitor, caffeine molecules. The smart nanocontainers encapsulate caffeine molecules at neutral pH, and release the molecules either under acidic or alkaline conditions, which make them spontaneously experience the pH excursions arisen from corrosion process and respond quickly.

An intelligent anticorrosion coating based on pH-responsive supramolecular nanocontainers.

The hollow mesoporous silica nanoparticles (HMSNs), which have been used as the nanocontainers for the corrosion inhibitor, benzotriazole, were fabricated using the hard-template method. Alkaline-responsive HMSNs based on cucurbit[6]uril (CB[6])/bisammonium supramolecular complex and acid-responsive HMSNs based on α-cyclodextrin (α-CD)/aniline supramolecular complex, which operate in water, have been achieved and characterized by solid-state NMR, thermogravimetry analysis, scanning electron microscopy, transmission electron microscopy and N(2) adsorption-desorption analysis. The two elaborately designed nanocontainers show the pH-controlled encapsulation/release behaviors for benzotriazole molecules.

pH-responsive nanovalves based on hollow mesoporous silica spheres for controlled release of corrosion inhibitor.

In the present study, a new encapsulation technique for corrosion inhibitor is proposed. The hollow mesoporous silica spheres (HMSs) were synthesized by the co-templates method as nanocontainers for corrosion inhibitor, benzotriazole (BTA) and the supramolecular nanovalves, consisting of cucurbit[6]uril (CB[6]) rings and the functional stalks attached to the surface of HMSs achieved on-demand release. The synthesis process of HMSs and the assembly process of the nanovalves were confirmed by SEM, TEM, N(2) adsorption/desorption, FTIR, TGA and solid-state (13)C CP/MAS NMR.