Correlations Among Serum Hepatitis B Surface Antigen and Hepatitis B e Antigen Titers and Viral Load in Chinese Patients with Chronic Hepatitis B.

Background: This study aimed to provide a detailed and comprehensive analysis of serum hepatitis B surface antigen (HBsAg), HBeAg, and serum hepatitis B virus (HBV) DNA in Chinese patients with chronic hepatitis B (CHB), predominantly genotypes B and C.

Methods: HBV serological markers, HBsAg titer, HBeAg titer, and HBV DNA were detected and genotyped in 129 Chinese patients with CHB.

Results: HBeAg-positive CHB patients were younger, had higher serum alanine aminotransferase, aspartate transaminase, and HBV DNA levels and were more likely to be infected with HBV genotype C.