Publications by authors named "Jia-Jie Yin"
Article Synopsis
- * High-intensity interval training (HIIT) showed significant antidepressant effects in a mouse model subjected to chronic mild stress and also improved the efficacy of fluoxetine, a standard antidepressant.
- * The study revealed that HIIT impacts the levels of HDAC2 and brain-derived neurotrophic factor (BDNF) in the ventral hippocampus, suggesting a potential molecular mechanism for its antidepressant effects, and highlighting HIIT as a viable option for treating MDD.
Atorvastatin ameliorates depressive behaviors via regulation of α7nAChR expression by PI3K/Akt-BDNF pathway in mice.
Biochem Biophys Res Commun
February 2022
Some of the statins have been shown to have antidepressant effects, but whether atorvastatin (AV) has antidepressant effects is unknown. This study was to investigate the effect of AV treatment on depressive behaviors. Herein, we show that AV treatment had antidepressant-like effect in physiological conditions and antidepressant effect in depressive state which depended on α7 nicotinic acetylcholine receptor (α7nAChR) expression in the ventral hippocampus (vHPC), but not α4β2 nicotinic acetylcholine receptor (α4β2nAchR) expression in vHPC, nor the α7nAChR and α4β2nAchR expression in dorsal hippocampus (dHPC).
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