Publications by authors named "Jia-Jie Lu"
Nucleus pulposus (NP) cells, situated at the core of intervertebral discs, have acclimated to a hypoxic environment, orchestrating the equilibrium of extracellular matrix metabolism (ECM) under the regulatory influence of hypoxia inducible factor-1α (HIF-1α). Neovascularization and increased oxygen content pose a threat, triggering ECM degradation and intervertebral disc degeneration (IVDD). To address this, our study devised an oxygen-controllable strategy, introducing laccase into an injectable and ultrasound-responsive gelatin/agarose hydrogel.
View Article and Find Full Text PDFArticle Synopsis
- Hepatocellular carcinoma (HCC) is a deadly cancer with a low survival rate, heavily linked to chronic liver diseases like hepatitis and alcoholism, and is notably increasing in patients with HIV.
- The study aimed to assess the survival outcomes of surgical resection in HCC patients co-infected with HIV, analyzing data from 56 individuals over a decade.
- Results indicated differences in survival rates between those who underwent surgery and those who received conservative treatment, with identifying key prognostic factors for the surgical group.
Article Synopsis
- The study tried to tell the difference between two medical conditions: tuberculous spondylodiscitis (TS) and pyogenic spondylodiscitis (PS) using tests and scans.
- They looked at data from 81 patients and found certain signs in tests that could help identify each condition better.
- The researchers created a new model that can predict the right diagnosis with a high accuracy of about 91.4%, which could help doctors make better decisions when treating patients.
Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis.
World J Gastroenterol
April 2024
Accurate preoperative diagnosis is highly important for the treatment of perivascular epithelioid cell tumors (PEComas) because PEComas are mainly benign tumors and may not require surgical intervention. By analyzing the causes, properties and clinical manifestations of PEComas, we summarize the challenges and solutions in the diagnosis of PEComas.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is a highly aggressive malignancy with a heterogeneous nature, which makes prognosis prediction and treatment determination difficult. Inflammation is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of tumours. Inflammation also affects the prognosis of GC patients.
View Article and Find Full Text PDFObjective: To evaluate the clinical characteristics, biochemical parameters and the distribution of HLA-DQ genotypes among adult patients with celiac disease (CD) in Northwest China.
Methods: This cross-sectional study retrospectively collected clinical, biochemical, and HLA-DQ genotype of patients with CD from a tertiary hospital in Xinjiang Uygur Autonomous Region, China between March 2016 and December 2021. Small intestinal biopsy and serum-specific antibodies were used to diagnose CD.
Mitochondrial dynamics, including mitochondrial fission and fusion, are critical for maintaining mitochondrial functions. Evidence shows that TANK-binding kinase 1 (TBK1) regulates mitochondrial fusion and fission and then mitophagy. Since a previous study demonstrates a strong correlation between mitophagy and osteoarthritis (OA), we herein investigated the potential role of TBK1 in OA process and mitochondrial functions.
View Article and Find Full Text PDFBackground: In December 2019, the cases of pneumonia of unknown etiology emerged in Wuhan, China, and rapidly spread throughout the country. The disease was later designated by the World Health Organization (WHO) as Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Few studies have assessed the clinical characteristics of COVID-19 and control strategies used to mitigate disease spread in high-altitude plateau regions of China.
View Article and Find Full Text PDFEpidemiological, clinical, and histological presentation of celiac disease in Northwest China.
World J Gastroenterol
March 2022
Article Synopsis
- - The study investigates celiac disease (CD) in northwest China, using data from 2,884 patients with gastrointestinal symptoms to understand its epidemiological, clinical, and pathological characteristics.
- - Among these patients, 50 were diagnosed with CD, with a higher detection rate in Kazakh individuals compared to other ethnic groups, and common symptoms including chronic diarrhea, anemia, and weight loss were reported.
- - Endoscopy findings showed significant gastrointestinal changes in CD patients, but differences in infection rates between CD and non-CD patients were not statistically significant, highlighting the need for more research in this area.
Article Synopsis
- Ulcerative colitis (UC) is a major type of inflammatory bowel disease that's notably prevalent in the Xinjiang region of China, with different symptoms seen in Uyghur and Han patients.
- The study analyzed tissue samples to identify potential biomarkers by examining the expression of miRNAs and mRNAs and predicting target genes.
- Ultimately, two miRNAs (hsa-miR-141-5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) linked to the varying symptoms of UC in the two populations were identified, suggesting their potential as biomarkers.
Objectives: Whether patent foramen ovale (PFO) closure is effective on migraine is controversial. This article was aimed at assessing the efficacy of PFO closure on migraine based on randomized controlled trials (RCTs) and observational studies.
Methods: We searched PubMed, Embase, and Cochrane databases up to October 2020 evaluating PFO closure versus control in patients with migraine, then conducted a meta-analysis of all RCTs and observational studies, respectively.
Association of infection with colorectal polyps and malignancy in China.
World J Gastrointest Oncol
May 2020
Article Synopsis
- Gastric infection is linked to various gastrointestinal issues like chronic gastritis and ulcers, but its connection to colorectal polyps and cancer is still debated.
- This study analyzed data from nearly 4,000 patients with colorectal polyps and over 300 with cancer to explore this relationship, focusing on factors like polyp size, pathology, and gastric infection prevalence.
- Results revealed that gastric infection was more common in patients with multiple adenomatous polyps and those with atrophic gastritis or intestinal metaplasia had a significantly higher risk of developing colorectal cancer.
High-flow oxygen inhalation is one of the most effective acute treatments for cluster headache. The therapy was first described for the treatment of cluster headache in 1952 by Horton, and has exhibited some advantages and efficacy compared to other acute medicines. The mechanism is not very clear, but some evidence has demonstrated its relationship to the trigeminovascular system and neuroinflammation.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer is a prevalent type of cancer, and this study focuses on sentinel polyps, which are rectal polyps associated with proximal colon cancer, to clarify their relationship.
- A retrospective analysis was conducted on 2,587 patients with rectal polyps to compare clinical features, treatment outcomes, and prognosis between those with sentinel polyps and those with only pure rectal polyps.
- Results showed that patients with sentinel polyps were generally older, had higher rates of anemia and tumor markers, and often presented with more complex polyp types; many had early-stage proximal colon cancer, while all patients in the pure rectal polyp group were successfully treated and discharged.
Objective: To investigate the effect of human concentration nucleoside transporters 1 (hCNT1/ SLC28A1) and multi-drug resistance protein 4 (MRP4/ABCC4) gene polymorphism on the response of chronic hepatitis B patients to nucleoside analogues treatment.
Methods: There were 136 patients of chronic hepatitis B treated with entecavir (68) or telbivudine (68). The allele and gene frequency distributing of the four loci of hCNT1/SLC28A1 and MRP4/ABCC4 as well as the polymorphisms were detected in all patients by multiplex snapshot single base extension method.
Objective: We aimed to study the association between HLA-DRB1 alleles and anti-neutrophil cytoplasmic antibodies (ANCA) among Uyghur and Han patients with ulcerative colitis (UC) in China.
Methods: Altogether 160 UC patients and 466 healthy controls of Uyghur and Han groups residing in the Xinjiang Uyghur Autonomous Region of China were included. HLA-DRB1 variants were identified from genomic DNA using polymerase chain reaction and gene sequencing.
To evaluate the therapeutic efficacy of antiviral combination therapy with pegylated-interferon alpha-2a plus ribavirin (RBV) in patients with autoantibody-positive chronic hepatitis C (CHC) and to investigate the impact of the presence of autoantibodies on the treatment outcome. Eighty-six consecutive CHC patients who underwent a 48-week treatment regimen composed of Peg-IFNa-2a (135 or 180 mug/wk) plus weight-based RBV ( less than or equal to 65 kg, 800 mg/d; 65 to 75 kg, 1000 mg/d; more than or equal to75 kg, 1200 mg/d ). Prior to treatment (baseline) and at end of treatment (EOT; week 48), levels of antinuclear antibody (ANA), anti-smooth muscle antibody (SMA), anti liver/kidney microsomal antibody type 1 (LKM1), anti-La (SSB), and anti liver cytosolic-1 (LC-1) were detected by indirect immunofluorescence.
View Article and Find Full Text PDFThe objective of this study was to compare the efficacy and safety of two rescue strategies for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients with resistance to adefovir dipivoxil (ADV). This prospective study included 58 HBeAg-positive CHB patients with resistance to ADV; 30 patients underwent telbivudine (LdT) plus ADV combination therapy and 28 patients switched to entecavir (ETV) monotherapy. After 48 weeks of treatment, the rates of hepatitis B virus (HBV) DNA <3 log10 copies/mL in the LdT plus ADV group and the ETV group were not significantly different (73.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated the connection between interferon regulatory element (IRE) mutations in the hepatitis B virus genome and the effectiveness of interferon therapy among chronic hepatitis B patients.
- Out of 62 patients, 64.5% responded to treatment while 35.5% did not, with specific mutations in the IRE region observed in non-responders.
- The findings suggest that a C to T mutation at the fourth base in the IRE may impair the effectiveness of interferon treatment, influencing patient responses.
Hemoperitoneum in cirrhotic patients without abdominal trauma or tumor.
Hepatobiliary Pancreat Dis Int
December 2011
Background: Hemoperitoneum is associated with several emergency conditions and is especially evident when it occurs in patients with liver cirrhosis. This study aimed to assess the clinical characteristics of cirrhotic patients who did not have abdominal trauma or tumor but who developed hemoperitoneum.
Methods: We reviewed the clinical records of 1276 consecutive cirrhotic patients with hemoperitoneum at our center between January 2007 and December 2009.
Background/aims: This study reports our preliminary experience of living donor liver transplantation (LDLT) for patients with acute-on-chronic liver failure (AoCLF) caused by hepatitis B.
Methodology: 47 patients who demonstrated Ao- CLF caused by hepatitis B with mean (±SD) Model for End-Stage Liver Disease scores of 39.2±5.