Quassinoids from Twigs of (Blanco) Merr and Their Anti-Parkinson's Disease Effect.

Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (-), were isolated from twigs of . Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed.

A Comprehensive Review of Pea ( L.): Chemical Composition, Processing, Health Benefits, and Food Applications.

L., commonly referred to as dry, green, or field pea, is one of the most common legumes that is popular and economically important. Due to its richness in a variety of nutritional and bioactive ingredients, the consumption of pea has been suggested to be associated with a wide range of health benefits, and there has been increasing focus on its potential as a functional food.

[Surveillance of epidemic factors of schistosomiasis in wetlands in Sichuan Province].

Objective: To investigate the epidemic factors of schistosomiasis in wetlands in Sichuan Province, so as to provide scientific evidence for the prevention and control of schistosomiasis in wetlands.

Methods: The artificial and natural wetlands were selected from Sichuan Province, and the relevant data regarding wetlands were collected. Routine snail survey, investigation on human morbidity due to schistosomiasis, snail diffusion experiments, questionnaire survey, determination of water infectivity and retrospective survey were conducted.

[Construction and application of the surveillance system for schistosomiasis transmission risk in Sichuan Province].

Objective: To build a schistosomiasis transmission risk surveillance system in Sichuan Province, so as to provide technical support for facilitating the progress towards schistosomiasis elimination in the province.

Methods: The surveillance sites for schistosomiasis transmission risk were assigned in 63 endemic counties (districts) of 11 cities (prefectures) in Sichuan Province. During the period from 2015 through 2018, wild feces contamination, the sources of infections (fever patients, livestock and wild animals), water infectivity in key settings, snail distribution in key settings, and snail breeding risk (snail importation and spread, floating debris carrying snails and snail breeding in ecological wetlands) were monitored in the surveillance sites.

Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components.

Cdc25 phosphatase was studied as an attractive target for cancer therapy. Multiple pharmacophore models with the unique core features of classic quinone inhibitors and those of novel inhibitors were used to discover a novel lead inhibitor. A total of 21 compounds with qualified physical properties were screened from the Maybridge HitFinder database containing 14 400 compounds by pharmacophore models.

[Schistosomiasis control progress and endemic situation in Sichuan Province].

Objective: To understand the schistosomiasis control progress and endemic situation, so as to provide the evidence for formulating the strategy of schistosomiasis elimination in Sichuan Province.

Methods: The schistosomiasis history data, working reports of schistosomiasis prevention and control, schistosomiasis surveillance data, and data of schistosomiasis prevention and control capacity were collected and analyzed for the schistosomiasis control progress and epidemic situation in Sichuan Province from 2004 to 2015.

Results: There were 63 schistosomiasis endemic districts in 11 cities in Sichuan Province, and the standard of schistosomiasis transmission interruption was achieved in the whole province in 2015.

[Establishment of index system of key factors on elimination of schistosomiasis].

Objective: To establish an index system of the key factors of elimination of schistosomiasis.

Methods: A questionnaire was designed based on the reference review, and 24 scientists working in the field of schistosomiasis control or research or management were investigated by using the Delphi method. The importance of each index reflecting the endemicity of schistosomiasis wis scored by each scientist.

[Mid-term evaluation on schistosomiasis control effect in Lushan earthquake-stricken areas in Sichuan Province].

Objective: To evaluate the effect of schistosomiasis control in Lushan earthquake-stricken areas in Sichuan Province, so as to provide the evidence for formulating appropriate measures for schistosomiasis prevention and control.

Methods: According to the data of historical schistosomiasis prevalence, 5 villages were selected as research sites and field investigations were conducted.

Results: The average density of Oncomelania hupensis snails was 0.