[Pharmacokinetic Study of Coagulation Factor Ⅷ in Adults with Severe Hemophilia A].

Objective: To detect the pharmacokinetic (PK) parameters of coagulation factor Ⅷ (FⅧ) in adult patients with severe hemophilia A, identify the potential factors influencing FⅧ PK, and optimize the use of FⅧ in individual prophylaxis regimens.

Methods: PK characteristics of FⅧ were studied in a total of 23 severe hemophilia A adults. The correlation of patients' characteristics including age, von Willebrand factor antigen (vWF:Ag), blood group, weight, body mass index (BMI) and genotype, with FⅧ PK were evaluated.

Recent advances in the contribution of circRNAs to cisplatin chemotherapy resistance in cancers.

Worldwide, cancer is a serious threat to the health of citizens of every country, with the incidence and mortality increasing year by year. Cisplatin is the first-line anticancer drug commonly used in clinics and is widely used for the treatment of solid tumors including lung, gastric, liver, bladder, and ovarian cancer. Although cisplatin-based chemotherapy has a high clinical response efficacy, patients will inevitably develop drug resistance after repeated use, leading to severe restrictions of its application.

[Acupuncture combined with western medication in treatment of type 2 diabetes mellitus with angina pectoris of coronary heart disease: a randomized controlled study].

Objective: To compare the therapeutic effect on type 2 diabetes mellitus (T2DM) complicated with angina pectoris of coronary heart disease between the combined therapy of acupuncture and western medication and the simple administration of western medication.

Methods: A total of 134 patients with T2DM and angina pectoris of coronary heart disease were randomly divided into two groups, i.e.

Combination and distribution characteristics of syndromes related to traditional Chinese medicine in patients with chronic heart failure: Protocol for a clinical study.

Introduction: Chronic heart failure has become one of the main diseases endangering human health in the 21st century. It is characterized by high morbidity and high mortality. With the continuous in-depth study of Traditional Chinese medicine, the treatment of heart failure by Tradional Chinese medicine has made significant progress, especially in improving the clinical symptoms of patients, controlling the development of the disease, and improving the quality of life of patients.

Crystal structure of ()-4-(3-carb-oxy-1-ethyl-6,8-di-fluoro-4-oxo-1,4-di-hydro-quinolin-7-yl)-2-methyl-piperazin-1-ium 3-carb-oxy-5-fluoro-benzoate.

In the title organic salt, CHFNO ·CHFO , proton transfer leads to one protonated lomefloxacin mol-ecule (HLf) and one 3-carb-oxy-5-fluoro-benzoate (5-F-Hip) anion in the asymmetric unit. The HLf cation is bent, with a dihedral angle of 38.3 (1)° between the quinoline ring and the piperazinium moiety.

Reaction-based SERS nanosensor for monitoring and imaging the endogenous hypochlorous acid in living cells.

Hypochlorous acid (HOCl), as an important reactive oxygen species (ROS), is involved with many pathological and physiological pathways, whereas many aspects of its roles remain unclear due to the lack of robust analytical methods. In this work, we report a novel kind of special reaction-based nanosensors, gold nanoparticles modified with newly synthesized 2-mercapto-4-methoxy-phenol molecules (AuNPs/MMP), to detect the endogenous HOCl in living cells according to the changes in the SERS spectrum of AuNPs/MMP resulting from the reaction of HOCl with MMP on AuNPs. These nanosensors can rapidly respond to HOCl within 1 min with the detection limit at 10 M level.

Tuberculous spondylitis after vertebral augmentation: A case report with a literature review.

Tuberculous spondylitis of vertebral augmentation following percutaneous vertebroplasty or kyphoplasty is rare. We report an unusual case of tuberculous spondylitis diagnosed after percutaneous kyphoplasty (PKP). A 54-year-old woman presented to hospital complaining of back pain following a fall 20 days prior.

Real-Time Sensing of O-Phenylenediamine Oxidation on Gold Nanoparticles.

Real-time monitoring of chemical reactions is still challenging as well as important to study reaction mechanisms and reaction kinetics. Herein, we demonstrated the real-time monitoring of o-phenylenediamine (OPD) oxidation on the surface of gold nanoparticles by surface-enhanced Raman spectroscopy (SERS). The oxidation mechanism and the reaction kinetics were investigated on the basis of the SERS spectrum variation and the related density functionalized theory calculation.

SERS nanoprobes for the monitoring of endogenous nitric oxide in living cells.

Nitric Oxide (NO) is a significant gaseous signalling molecule in various pathological and physiological pathways, whereas many of its functions are still ambiguous in part because of the shortage of powerful detection approaches. Herein, we present a type of reaction-based surface-enhanced Raman scattering (SERS) nanoprobes, o-phenylenediamine-modified gold nanoparticles (AuNPs/OPD), to detect the level of the endogenous NO in living cells. The detection is achieved through the SERS variation of AuNPs/OPD caused by the reaction between NO and OPD on the surface of AuNPs.

Effect and Prognostic Factors of Laminoplasty for Cervical Myelopathy With an Occupying Ratio Greater Than 50%.

Study Design: A retrospective study.

Objective: The aim of this study was to evaluate the efficacy of laminoplasty for the treatment of patients with an occupying ratio greater than 50% and to determine possible factors related to surgical outcome of posterior decompression.

Summary Of Background Data: Little data are available about effect and prognostic factors of laminoplasty for cervical myelopathy with an occupying ratio greater than 50%.

Pooled analysis of pomalidomide for treating patients with multiple myeloma.

Background: Patients with refractory or relapsed multiple myeloma are considered to have a very poor prognosis, and new regimens are needed to improve this setting. Pomalidomide is a new immunomodulatory drug with high in vitro potency. Immunomodulatory drugs are hypothesized to act through multiple mechanisms.

Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice.

Cerebellar ataxias, which comprise a wide spectrum of progressive disorders, are incurable at present. It has been reported that human umbilical mesenchymal stem cell (HU-MSC) transplantation has a protective effect on neurodegenerative diseases. In this study, we investigated the effect of HU-MSCs on ataxic mice induced by cytosine beta-D-arabinofuranoside (Ara-C).