Publications by authors named "Jia-Ji Pan"

Article Synopsis
  • Low-intensity focused ultrasound stimulation (LIFUS) was tested on mice to understand its effect on recovery after ischemic stroke, focusing on blood flow improvement, cell repair, and behavioral outcomes.
  • After LIFUS treatment, researchers found increased cerebral blood flow, enhanced neurobehavioral performance, and significant changes in protein expression related to brain repair processes.
  • The study concluded that LIFUS helps promote healing by upregulating key proteins like HMGB1 and decreasing CAMK2N1, which are important for angiogenesis and synaptogenesis in the brain.
View Article and Find Full Text PDF

Protecting the integrity of the blood-brain barrier (BBB) is crucial for maintaining brain homeostasis after ischemic stroke. Previous studies showed that M2 microglial extracellular vesicles (EVs) played a neuroprotective role in cerebral ischemia. However, the role of M2 microglial EVs in maintaining BBB integrity is unclear.

View Article and Find Full Text PDF

White matter repair is critical for the cognitive and neurological functional recovery after ischemic stroke. M2 microglia are well-documented to enhance remyelination and their extracellular vesicles (EVs) mediate cellular function after brain injury. However, whether M2 microglia-derived EVs could promote white matter repair after cerebral ischemia and its underlying mechanism are largely unknown.

View Article and Find Full Text PDF

Exosomes are natural cells-derived vesicles, which are at the forefront toward clinical success for various diseases, including cerebral ischemia. Exosomes mediate cell-to-cell communication in different brain cells during both physiological and pathological conditions. Exosomes are an extensively studied type of extracellular vesicle, which are considered to be the best alternative for stem cell-based therapy.

View Article and Find Full Text PDF