Publications by authors named "Jia-He Xi"
Piperine, a natural amide isolated from the genus of , serves as a pharmacophore in medicinal chemistry. In this study, we synthesised and evaluated 18 novel piperine-acylhydrazone hybrids (-) for their antiproliferative activities . The structures of these hybrids were validated using H,C NMR, and HR-ESI-MS data.
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- * Researchers identified 45 active components in SQW and 72 potential COVID-19-related targets, highlighting key proteins such as ACE2 and IL-6, and found significant enrichment in 1715 gene ontology (GO) projects and 136 KEGG pathways related to inflammation and cellular response.
- * Molecular docking studies indicated strong binding capabilities of several active compounds like kaempferol and quercetin with important COVID-19 targets, suggesting SQW could be effective in managing the disease.