Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition.

Aims: MicroRNA-126 (miR-126), one of the most abundant microRNAs in platelets, is involved in the regulation of platelet activity and the circulating miR-126 is reduced during antiplatelet therapy. However, whether intraplatelet miR-126 plays a role in thrombosis and platelet inhibition remains unclear.

Methods And Results: Here, using tissue-specific knockout mice, we reported that the deficiency of miR-126 in platelets and vascular endothelial cells significantly prevented thrombosis and prolonged bleeding time.

Toxicological responses, bioaccumulation, and metabolic fate of triclosan in Chlamydomonas reinhardtii.

Triclosan (TCS) is a broad-spectrum antimicrobial agent that is broadly used in personal care products. It has been shown to cause the contamination of a variety of aquatic environments. Since algae has been the primary producers of aquatic ecosystems, understanding the toxicological mechanisms and the metabolic fate of TCS is vital for assessing its risk in an aquatic environment.

A novel strategy for selective removal and rapid collection of triclosan from aquatic environment using magnetic molecularly imprinted nano-polymers.

Triclosan (TCS) is a kind of chronic toxicity to aquatic organisms. Due to its highly effective antimicrobial, TCS has been widely applied in personal-care products, which naturally poses a potential risk to the ecological system and human health since its release into water-ecological environment. Therefore, it urgently demands a selective, easily separated, recyclable, and low-cost adsorbent to remove the residues of TCS from aquatic environments.

Preparation of core-shell magnetic molecularly imprinted polymer nanoparticle for the rapid and selective enrichment of trace diuron from complicated matrices.

A novel magnetic MIPs (DUMIPs) was prepared by surface molecular imprinting method using superparamagnetic core-shell nanoparticle (FeO@SiO) as the sacrificial support matrix, herbicide diuron as template, α-methacrylic acid as the functional monomer, trimethylolpropane trimethacrylate as the crosslinker, azobisisobutyronitrile as the initiator, and acetonitrile as the porogen. Highly cross-linked porous surface and excellent magnetic property were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometer, respectively. The adsorption capacity of DUMIPs was 8.