Publications by authors named "Jia-Gui Zhong"
Article Synopsis
- * A study using a rat model induced with lithium-pilocarpine examined changes in the hippocampus, revealing 27 differentially expressed proteins related to synaptic plasticity and structure after 2 weeks of spontaneous seizures.
- * Findings showed significant upregulation of certain proteins and increased dendritic spines, suggesting that synaptic remodeling plays a key role in the development of TLE, offering insights for further research on synaptic plasticity in this condition.
Temporal lobe epilepsy (TLE) is a common chronic neurological disease that is often invulnerable to anti-epileptic drugs. Increasing data have demonstrated that acetylcholine (ACh) and cholinergic neurotransmission are involved in the pathophysiology of epilepsy. Cytisine, a full agonist of α7 nicotinic acetylcholine receptors (α7nAChRs) and a partial agonist of α4β2nAChRs, has been widely applied for smoking cessation and has shown neuroprotection in neurological diseases.
View Article and Find Full Text PDFTemporal lobe epilepsy (TLE) is a chronic neurological disorder that is a refractory disease. Baicalein possesses various pharmacological activities, including neuroprotection in neurodegenerative disease. However, whether baicalein is protective in the treatment of TLE is not determined.
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