Zhongguo Ying Yong Sheng Li Xue Za Zhi
June 2018
Objective: To investigate the effects of Birinapant on hepatocellular carcinoma cells and its related molecular mechanisms.
Methods: Human hepatocellular carcinoma cells QGY-7701 were treated with 0, 1, 5, 25 and 125 nmol/L Birinapant for 24, 48 and 72 hours respectively, each experiment 3 wells.The proliferation activity of cells, the apoptosis levels, the cells nuclear type, the mitochondrial membrane potential, the transcription and expression levels of genes and the cytotoxicity of Birinapant were analyzed.