Publications by authors named "Jia-Fang Cui"
Article Synopsis
- The study investigates how tacrolimus affects proteinuria in patients suffering from idiopathic membranous nephropathy (IMN), using a machine learning model for analysis.
- Data collected from existing literature and 463 IMN patients was analyzed to determine the drug's effectiveness based on changes in proteinuria levels.
- Results indicate that to achieve optimal therapeutic effects, tacrolimus concentrations should be maintained within the range of 4-10 ng/ml for a minimum of 1.72 months.
Article Synopsis
- The study investigates how to optimize cyclosporin dosing for pediatric refractory nephrotic syndrome (PRNS), considering the impact of spironolactone, a drug known to influence cyclosporin metabolism.
- Using a Monte Carlo simulation, researchers developed dosing regimens tailored to different body weights for patients with and without spironolactone.
- The findings suggest specific dosing adjustments for cyclosporin in PRNS to enhance treatment effectiveness and ensure safe drug concentration levels in young patients.
Objectives: Cyclosporin is one of the therapeutic regimens for hemophagocytic lymphohistiocytosis (HLH); however, the optimal dosage of cyclosporine in children with HLH is unknown. It has been found that piperacillin-tazobactam affects the cyclosporine pharmacokinetic process in pediatric HLH patients. Thus, the purpose of the present study was to recommend cyclosporin dosage for pediatric HLH with and without piperacillin- tazobactam.
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