Publications by authors named "Jia-Da Zhang"
Article Synopsis
- Previous studies indicated that the antimicrobial agents triclocarban (TCC) and triclosan (TCS) disrupt lipid metabolism, but research on their effects specifically on adipose (fat) tissue is limited.
- This study found that TCC promotes the differentiation of preadipocytes into mature adipocytes more than TCS, activating multiple peroxisome proliferator-activated receptors (PPARs), while TCS mainly activates one type of PPAR.
- In in vivo experiments, TCC increased fat accumulation and body weight in mice, with male mice showing greater susceptibility to TCC's obesogenic effects.
Triclosan (TCS) and triclocarban (TCC) have become ubiquitous pollutants detected in human body with concentrations up to hundreds of nanomolar levels. Previous studies about the hepatic lipid accumulation induced by TCS and TCC were focused on pollutant itself, which showed weak or no effects. High-fat diet (HFD), as a known environmental factor contributing to lipid metabolism-related disorders, its synergistic action with environmental pollutants deserves concern.
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- - Neonicotinoid insecticides (NIs) are prevalent in the environment and human bodies, showing concentrations that could potentially affect health, but their mechanisms regarding toxicity, especially in relation to breast cancer, remain unclear.
- - Research focused on the G protein-coupled estrogen receptor (GPER) found that certain NIs, particularly acetamiprid (ACE), significantly activated GPER, leading to increased migration and proliferation of breast cancer cells.
- - ACE was shown to promote breast cancer growth and lung metastasis in mouse models via the GPER mechanism, suggesting that NIs could potentially exacerbate breast cancer progression at levels encountered in human exposure.
Article Synopsis
- Benzotriazole ultraviolet stabilizers (BUVs) are emerging environmental pollutants that may disrupt hormone functions by interacting with estrogen-related receptors α and γ (ERRα and ERRγ).
- The study found that BUVs bind effectively to ERRγ, promoting its transcriptional activity at low concentrations relevant to human exposure.
- Molecular analyses indicate that factors like molecular polarizability and electron-donating ability significantly influence how BUVs bind to ERRγ, highlighting their potential estrogenic effects.