sp. nov., isolated from aquatic environments in the northern PR China.

Four strains (km711, km714, km542 and km524), representing a novel species, were isolated from aquatic environments in northern PR China. Cells were Gram-stain-negative, rod-shaped, microaerobic, motile and growth depended on l-cysteine. They grew at 25‒42 °C (optimum, 35‒37 °C) and could tolerate up to 1.

Micro-Drilling of Sapphire using Electro Chemical Discharge Machining.

Electrochemical discharge machining (ECDM) refers to a non-traditional machining method for performing effective material removal on non-conductive hard and brittle materials. To increase the ECDM machining efficiency, traditionally, the method of increasing the machining voltage or increasing the electrolyte concentration is used. These methods can also cause overcut reaming of the drilled holes and a rough surface on the heat affected area.

Syndrome Differentiation Analysis on Mars500 Data of Traditional Chinese Medicine.

Mars500 study was a psychological and physiological isolation experiment conducted by Russia, the European Space Agency, and China, in preparation for an unspecified future manned spaceflight to the planet Mars. Its intention was to yield valuable psychological and medical data on the effects of the planned long-term deep space mission. In this paper, we present data mining methods to mine medical data collected from the crew consisting of six spaceman volunteers.

EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease.

Erythropoietin (EPO) may become a potential therapeutic candidate for the treatment of the neurodegenerative disorder -- Parkinson's disease (PD), since EPO has been found to prevent neuron apoptosis through the activation of cell survival signalling. However, the underlying mechanisms of how EPO exerts its neuroprotective effect are not fully elucidated. Here we investigated the mechanism by which EPO suppressed 6-hydroxydopamine (6-OHDA)-induced neuron death in in vitro and in vivo models of PD.

[Genotyping for CYP2C19 with multiplex PCR point mutation screening technology].

Objective: To establish a multiplex PCR point mutation screening technique for the genotyping of CYP2C19.

Methods: Deoxyinosine multiplex-polymerase chain reaction (PCR) primers (DMPs) were designed to detect simultaneously CYP2C19*1,*2,*3 alleles in one PCR tube.

Results: The above technique could detect the genotypes of CYP2C19*1, CYP2C19*2 and CYP2C19*3 successfully.

Non-invasive prenatal diagnosis of trisomy 21 by reverse transcriptase multiplex ligation-dependent probe amplification.

Background: Obtaining fetal DNA or RNA by either chorionic villus sampling (CVS) or amniocentesis is currently, the gold standard prenatal diagnosis. However, these invasive procedures carry risk of miscarriage. A reliable method for non-invasive prenatal diagnosis (NIPD) has long been sought to reduce the risk of miscarriage.

A library of L-tyrosine-derived biodegradable polyarylates for potential biomaterial applications, part I: synthesis, characterization and accelerated hydrolytic degradation.

A combinatorial library of biodegradable polyarylates derived from L-tyrosine was synthesized and characterized. These polyarylates are A-B-type co-polymers consisting of a cyclic dipeptide and a diacid. General structure-property correlations were established by comparing aryl diacid co-polymers and aliphatic diacid co-polymers.

[Association between SNAP-25 gene polymorphism and attention deficit hyperactivity disorder].

Objective: To analyse the association between polymorphism in human synaptosomal-associated protein of 25 000 (SNAP-25) gene and attention deficit hyperactivity disorder (ADHD) in Han Chinese children.

Methods: The study samples were comprised of 100 integrated ADHD trios (included proband and biological parents) and 97 unrelated controls. Association of polymorphism with ADHD and its subtype was examined by: (1) comparing cases and controls; (2) using family-based association study in transmission disequilibrium test (TDT).