A universal incision for robot-assisted thoracic surgery.

Objective: This paper aimed to design and explore the versatility of the incision for the robot-assisted thoracic surgery.

Methods: The concept of universal incision was designed and put forward. The clinical data of 342 cases of robot-assisted thoracic surgery were summarized, including sex, age, clinical diagnosis, operative method, operative time, conversion to thoracotomy, intraoperative blood loss, number of lymph node dissections, postoperative hospital stays, postoperative pathology, and postoperative complications of the patients.

Characteristics of Seed Vigor in Rice Varieties with Different Globulin Accumulations.

Seed vigor of rice is an important trait for direct seeding. The objective of this study was to reveal the relationship between globulin and seed vigor, and then to explore a method for evaluating seed vigor. Several rice varieties with different levels of 52 kDa globulin accumulation were used to compare seed vigor under normal and aged conditions.

Compare the performance of multiple machine learning models in predicting tacrolimus concentration for infant patients with living donor liver transplantation.

Background: This study aims to establish multiple ML models and compare their performance in predicting tacrolimus concentration for infant patients who received LDLT within 3 months after transplantation.

Methods: Retrospectively collected basic information and relevant biochemical indicators of included infant patients. CMIA was used to determine tacrolimus C .

Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity.

Ethnopharmacological Relevance: Psoralea corylifolia (P. corylifolia Linn.) is a traditional Chinese medicinal plant that exhibits significant aphrodisiac, diuretic, and anti-rheumatic effects.

Molecularly Distorted Local Structure in Bi CuO Oxide to Stabilize Lattice Oxygen for Efficient Formate Electrosynthesis.

The electrochemical CO reduction reaction (CO RR) provides an economically feasible way for converting green energy into valuable chemical feedstocks and fuels. Great progress has been achieved in the understanding and synthesis of oxidized-based precatalysts; however, their dynamical changes of local structure under operando conditions still hinder their further applications. Here a molecularly distorted Bi CuO precatalyst for efficient CO -to-formate conversion is reported.

Correlation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018.

Background: Prevalence rates of hyperuricemia and gout are increasing. Clinical investigations of hyperuricemia-related risk factors aid in the early detection, prevention, and management of hyperuricemia and gout. Ongoing research is examining the association of obesity, dietary patterns, and blood pressure (BP) with serum uric acid (sUA).

A novel electrochemical sensor for glucose detection based on a TiCT /ZIF-67 nanocomposite.

A TiCT /ZIF-67 nanocomposite with outstanding conductivity has been prepared by loading ZIF-67 onto a two-dimensional TiCT nanosheet. TiCT sheets were synthesized by etching TiAlC, and then ZIF-67 was grown on the TiCT nanosheet. The TiCT /ZIF-67 nanocomposite exhibits excellent detection performance for glucose, with a low LOD of 3.

Efficacy and safety of camrelizumab in combination with neoadjuvant chemotherapy for ESCC and its impact on esophagectomy.

Background: Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in China. The use of neoadjuvant immunotherapy for the treatment of ESCC is gradually increasing. Camrelizumab is one such immune checkpoint inhibitor (ICI) used for treatment.

Generation of a RRAGA knockout human iPSC line GIBHi002-A-5 using CRISPR/Cas9 technology.

Ras-related GTP-binding protein A (RagA), encoded by RRAGA gene, initially senses the availability of cellular amino acids (e.g., leucine) and controls the translocation of mTORC1 to the lysosomal membrane.

SUMOylation of Nuclear γ-Actin by SUMO2 supports DNA Damage Repair against Myocardial Ischemia-Reperfusion Injury.

Myocardial infarction triggers oxidative DNA damage, apoptosis and adverse cardiac remodeling in the heart. Small ubiquitin-like modifier (SUMO) proteins mediate post-translational SUMOylation of the cardiac proteins in response to oxidative stress signals. Upregulation of isoform SUMO2 could attenuate myocardial injury via increasing protein SUMOylation.

Dietary nitrate supplementation and small muscle mass exercise hemodynamics in patients with essential hypertension.

Exaggerated blood pressure and diminished limb hemodynamics during exercise in patients with hypertension often are not resolved by antihypertensive medications. We hypothesized that, independent of antihypertensive medication status, dietary nitrate supplementation would increase limb blood flow, decrease mean arterial pressure (MAP), and increase limb vascular conductance during exercise in patients with hypertension. Patients with hypertension either abstained from ( = 14, Off-Meds) or continued ( = 12, On-Meds) antihypertensive medications.

An unusual presentation of fucosidosis in a Chinese boy: a case report and literature review (childhood fucosidosis).

Background: Fucosidosis is one of the rare autosomal recessive lysosomal storage diseases (LSDs) attributed to FUCA1 variants causing the deficiency of α-L-fucosidase in vivo. Α-L-fucosidase deficiency will cause excessive accumulation of fucosylated glycoproteins and glycolipids, which eventually leads to dysfunction in all tissue systems and presents with multiple symptoms. Fucosidosis is a rare disease which is approximately 120 cases have been reported worldwide (Wang, L.

Progress of Research on the Application of Triple Antibiotic Paste and Hydrogel Scaffold Materials in Endodontic Revascularization: A Systematic Review.

Objective: To evaluate the application of hydrogel scaffold materials and triple antibiotic paste in endodontic regeneration through literature review.

Methods: An electronic search of the literature published on PubMed, Wangfang database, and CNKI database using the search terms "endodontic regeneration," "pulp blood flow reconstruction," "recanalization," "triple antibiotic paste," and "scaffold material" was conducted. The searched literature was used for analysis.

Non-GDANets: Sports small object detection of thermal images with Non-Glodal decoupled Attention.

Because thermal infrared sport targets have rich and complex semantic information, there is a high coupling between different types of features. In view of these limitations, we propose a Non-Glodal decoupled Attention, namely,local U-shaped attention decoupling network (LUANets), which aims to decompose the coupling relationship of different sport target features in thermal infrared images and establish effective spatial dependence between them. This method takes the captured multi-scale initial features according to different levels and inputs them into the local decoupling module with U-shaped attention structure to realize the decomposition of semantic details.

Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics.

Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a wide range of traits using summary statistics from genome-wide association studies (GWASs). Existing summary-level MR methods often rely on strong assumptions, resulting in many false-positive findings. To relax MR assumptions, ongoing research has been primarily focused on accounting for confounding due to pleiotropy.

Rab27a-dependent exosomes protect against cerebral ischemic injury by reducing endothelial oxidative stress and apoptosis.

Introduction: Multicellular crosstalk within the brain tissue has been suggested to play a critical role in maintaining cerebral vascular homeostasis. Exosomes (EXs) mediated cell-cell communication, but its role in cerebral ischemic injury is largely unknown. Rab27a is one of the major genes controlling EX release.

Trust violations affect the emotional working memory updating: An event-related brain potential study.

Previous studies found that trust violations impaired the ability of working memory (WM) updating, however, these studies did not consider the emotional context in the WM updating. Individuals who experience trust violations have the characteristics of negative bias and enhanced negative emotion. Thus it is necessary to explore how emotional contexts moderate the relationship between trust violations and WM updating.

[Clinical effect of fluid resuscitation guided by intra-abdominal pressure and oxygenation index for severe acute pancreatitis patients].

Objective: To investigate the effect of the liquid resuscitation therapy strategy using intra-abdominal pressure (IAP) and oxygenation index (PaO/FiO) as the end point in patients with severe acute pancreatitis (SAP).

Methods: A retrospective study was performed, including 84 patients with SAP in emergency intensive care unit of Qingzhou Hospital Affiliated to Shandong First Medical University from January 2018 to August 2021. According to the status of fluid balance at admission, all patients were divided into the positive fluid balance group (43 cases) and the negative fluid balance group (41 cases).

[Development of nutrient profiling model include nutrients and food groups evaluation].

Objective: To develop the nutrient profiling model based on the nutrition and health status of Chinese residents, and comprehensively evaluate the nutritional quality of food and dietary pattern.

Methods: Nutrient-and food group-indexes closely related to the main health problems of Chinese residents were screened and determined based on the level of evidence. Different food and dietary patterns were taken as examples to calculate the nutrient dense score.

Polysaccharide extract from Isatidis Radix inhibits multiple inflammasomes activation and alleviate gouty arthritis.

The polysaccharide extract from Isatidis Radix exhibits potent antiinflammatory and antiviral activities, but the mechanism of Isatidis Radix polysaccharide (IRP) remains obscure. Herein, we reported that IRP blocked the activation of nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, leading to the inhibiting of caspase-1 cleavage and IL-1β secretion. Mechanistically, IRP did not inhibit NLRP3 inflammasome through suppressing mitochondrial reactive oxygen species (mtROS) production.

Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1.

Background: Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal disease, esophageal squamous cell carcinoma (ESCC).

Methods: The expression of HDAC3 in clinically collected ESCC tissues was determined by RT-qPCR and immunohistochemistry.

FIRM: Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets.

Single-cell RNA-sequencing (scRNA-seq) is being used extensively to measure the mRNA expression of individual cells from deconstructed tissues, organs and even entire organisms to generate cell atlas references, leading to discoveries of novel cell types and deeper insight into biological trajectories. These massive datasets are usually collected from many samples using different scRNA-seq technology platforms, including the popular SMART-Seq2 (SS2) and 10X platforms. Inherent heterogeneities between platforms, tissues and other batch effects make scRNA-seq data difficult to compare and integrate, especially in large-scale cell atlas efforts; yet, accurate integration is essential for gaining deeper insights into cell biology.

[Cervical Primary Ewing's Sarcoma:Report of One Case].

Ewing's sarcoma in the cervix is characterized by extremely rare occurrence,high degree of malignancy,and rapid progression.The diagnosis of this disease is based on pathology and immunohistochemistry. The main image of the case reported in this paper showed the cervical cyst with solid mass,large volume,and uneven density and signal,and the solid part can be strengthened in enhanced scanning.