Publications by authors named "Jia Yu Gong"
Article Synopsis
- The research investigates how a maternal high-fat diet and gestational diabetes affect the metabolism of lipids and the profile of polyunsaturated fatty acids (PUFA) in their offspring.
- Offspring are classified into different groups based on their mother's diet and GDM status, and their PUFA composition and protein signaling are analyzed using techniques like gas chromatography and Western blotting.
- Findings suggest that exposure to high-fat diets and gestational diabetes during early development can alter PUFA profiles and protein expression related to signaling pathways in male offspring as they grow into adulthood.
Objective: Fatty acids play a critical role in the proper functioning of the brain. This study investigated the effects of a high-fat (HF) diet on brain fatty acid profiles of offspring exposed to maternal gestational diabetes mellitus (GDM).
Methods: Insulin receptor antagonist (S961) and HF diet were used to establish the GDM animal model.
Background: Polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA), are critical for proper fetal brain growth and development. Gestational diabetes mellitus (GDM) could affect maternal-fetal fatty acid metabolism.
Objective: This study aimed to explore the effect of GDM and high-fat (HF) diet on the DHA transport signaling pathway in the placenta-brain axis and fatty acid concentrations in the fetal brain.
Article Synopsis
- The study investigates the impact of dietary patterns and maternal genetics on the concentration of polyunsaturated fatty acids (PUFAs) in breast milk from Chinese Han lactating mothers.
- A survey was conducted with 370 participants, collecting data on dietary intake and breast milk samples to analyze PUFA levels and genetic variations.
- Findings indicate that both maternal genetic factors and dietary intake significantly influence the PUFA levels in breast milk, highlighting the importance of essential fatty acids for breastfeeding mothers.
Background: Fatty acids, especially polyunsaturated fatty acid (PUFA), are found abundantly in the brain and are fundamental for a fetus's growth. The fatty acid profiles of mothers and fetuses may be affected by maternal prepregnancy body mass index (pre-BMI), thus affecting fetal growth and development.
Methods: A total of 103 mother-fetus pairs were divided into overweight/obese (OW, = 26), normal weight (NW, = 60), and underweight (UW, = 17) groups according to pre-BMI.