Prognostic significance of stress dynamic myocardial CT perfusion: comparison with CT-FFR and CT angiography stenosis-the multicenter VALIDITY trial.

Objectives: This study aimed to investigate the prognostic significance of stress dynamic myocardial CT perfusion imaging (CTP) and determine whether it has incremental advantages over coronary computed tomography angiography (CTA)-derived parameters.

Methods: This prospective multicenter study included patients with suspected coronary artery disease who had undergone coronary CTA and CTP and were followed for 6 years. The endpoint was time-to-first major adverse cardiovascular event (MACE).

Rational design and synthesis of triazene-amonafide derivatives as novel potential antitumor agents causing oxidative damage towards DNA through intercalation mode.

In this work, we rationally designed and synthesized two novel triazene-amonafide derivatives 2-(2-(diisopropylamino)ethyl)-5-(3,3-dimethyltriaz-1-en-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (D-11) and 5-(3,3-diethyltriaz-1-en-1-yl)-2-(2-(diisopropylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (D-12) as potential antitumor agents. The DNA damage induced by the intercalation mode of D-11 (D-12) towards DNA was electrochemically detected through the construction of efficient biosensors. The consecutive processes of reversible redox of naphthylimide ring and irreversible oxidation of triazene moiety were elucidated on the surface of glassy carbon electrode (GCE) by CV, SWV, and DPV methods.

Machine learning based ischemia-specific stenosis prediction: A Chinese multicenter coronary CT angiography study.

Objectives: To evaluate the performance of coronary computed tomography angiography (CCTA) derived characteristics including CT derived fractional flow reserve (CT-FFR) with FFR as a reference standard in identifying the lesion-specific ischemia by machine learning (ML) algorithms.

Methods: The retrospective analysis enrolled 596 vessels in 462 patients (mean age, 61 years ± 11 [SD]; 71.4 % men) with suspected coronary artery disease who underwent CCTA and invasive FFR.

The incremental value of CCTA-derived myocardial radiomics signature for ischemia diagnosis with reference to CT myocardial perfusion imaging.

Objectives: To explore the incremental value of myocardial radiomics signature derived from static coronary computed tomography angiography (CCTA) for identifying myocardial ischemia based on stress dynamic CT myocardial perfusion imaging (CT-MPI).

Methods: Patients who underwent CT-MPI and CCTA were retrospectively enrolled from two independent institutions, one used as training and the other as testing. Based on CT-MPI, coronary artery supplying area with relative myocardial blood flow (rMBF) value <0.

Optimal Measurement Sites of Coronary-Computed Tomography Angiography-derived Fractional Flow Reserve: The Insight From China CT-FFR Study.

Objectives: To investigate the optimal measurement site of coronary-computed tomography angiography-derived fractional flow reserve (FFR CT ) for the assessment of coronary artery disease (CAD) in the whole clinical routine practice.

Materials And Methods: This retrospective multicenter study included 396 CAD patients who underwent coronary-computed tomography angiography, FFR CT , and invasive FFR. FFR CT was measured at 1 cm (FFR CT -1 cm), 2 cm (FFR CT -2 cm), 3 cm (FFR CT -3 cm), and 4 cm (FFR CT -4 cm) distal to coronary stenosis, respectively.

Cardiovascular Imaging in China: Yesterday, Today, and Tomorrow.

The high prevalence and mortality of cardiovascular diseases in China's large population has increased the use of cardiovascular imaging for the assessment of conditions in recent years. In this study, we review the past 20 years of cardiovascular imaging in China, the increasingly important role played by cardiovascular computed tomography in coronary artery disease and pulmonary embolism assessment, magnetic resonance imaging's use for cardiomyopathy assessment, the development and application of artificial intelligence in cardiovascular imaging, and the future of Chinese cardiovascular imaging.

Functional CAD-RADS using FFR on therapeutic management and prognosis in patients with coronary artery disease.

Objectives: To propose a novel functional Coronary Artery Disease-Reporting and Data System (CAD-RADS) category system integrated with coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) and to validate its effect on therapeutic decision and prognosis in patients with coronary artery disease (CAD).

Methods: Firstly, we proposed a novel functional CAD-RADS and evaluated the performance of functional CAD-RADS for guiding treatment strategies with actual clinical treatment as a reference standard in a retrospective multicenter cohort with CCTA and invasive FFR performed in all patients (n = 466). Net reclassification improvement (NRI) of functional CAD-RADS over anatomical CAD-RADS was calculated.

Phytosterols in hull-less pumpkin seed oil, rich in ∆-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats.

Background: Pumpkin seed oil is widely used to treat benign prostatic hyperplasia (BPH), a common disease in elder men. However, its active components and mechanism have remained to be elucidated.

Objective: The objective of the present study was to investigate the active components of pumpkin seed oil and its mechanism against BPH.

The effect of coronary calcification on diagnostic performance of machine learning-based CT-FFR: a Chinese multicenter study.

Objective: To investigate the effect of coronary calcification morphology and severity on the diagnostic performance of machine learning (ML)-based coronary CT angiography (CCTA)-derived fractional flow reserve (CT-FFR) with FFR as a reference standard.

Methods: A total of 442 patients (61.2 ± 9.

Stress dynamic myocardial CT perfusion for symptomatic patients with intermediate- or high-risk of coronary artery disease: Optimization and incremental improvement between the absolute and relative myocardial blood flow analysis.

Background: The optimization of myocardial CT perfusion (CTP) assessment remains inconsistent and uncertain. Our aim was to explore the superior analysis selection and incremental improvement of myocardial blood flow (MBF) assessment on CTP in diagnosing hemodynamically significant coronary artery disease (CAD).

Methods: Sixty patients (43 men and 17 women; 61.

The influence of image quality on diagnostic performance of a machine learning-based fractional flow reserve derived from coronary CT angiography.

Objective: To investigate the effect of image quality of coronary CT angiography (CCTA) on the diagnostic performance of a machine learning-based CT-derived fractional flow reserve (FFR).

Methods: This nationwide retrospective study enrolled participants from 10 individual centers across China. FFR analysis was performed in 570 vessels in 437 patients.

CT FFR for Ischemia-Specific CAD With a New Computational Fluid Dynamics Algorithm: A Chinese Multicenter Study.

Objectives: The aim of this study was to validate the feasibility of a novel structural and computational fluid dynamics-based fractional flow reserve (FFR) algorithm for coronary computed tomography angiography (CTA), using alternative boundary conditions to detect lesion-specific ischemia.

Background: A new model of computed tomographic (CT) FFR relying on boundary conditions derived from structural deformation of the coronary lumen and aorta with transluminal attenuation gradient and assumptions regarding microvascular resistance has been developed, but its accuracy has not yet been validated.

Methods: A total of 338 consecutive patients with 422 vessels from 9 Chinese medical centers undergoing CTA and invasive FFR were retrospectively analyzed.

Photodynamic Therapy Mediated by Upconversion Nanoparticles to Reduce Glial Scar Formation and Promote Hindlimb Functional Recovery After Spinal Cord Injury in Rats.

Glial scar formation is one of the major consequences of spinal cord injury, which prevents the regenerated axons passing the injured area and forming effective synaptic connection. In this paper, we used photodynamic therapy (PDT), which was mediated by the upconversion nanoparticles coated with polyethylene glycol (PEG) and photosensitizer (UCNPs-PEGM540), to reduce the glial scar formation after spinal cord injury. The in vitro experimental results indicated that cultured astrocytes could be killed by using upconversion nanoparticles after excitation with near infrared light.

A protocol of homozygous haploid callus induction from endosperm of Taxus chinensis Rehd. var. mairei.

Obtainment and characterization of the novel endosperm callus of Taxus chinensis Rehd. var. mairei are valuable for haploid breeding, genome, and functional genome in Taxus.

A preliminary investigation of computed tomographic angiography in the assessment of coronary artery distensibility.

Objective: To test 2 hypotheses: first, that coronary distensibility can be measured noninvasively using 64-slice computed tomographic angiography (CTA); and second, that the extent of coronary artery disease (CAD) in any individual patient is related to the degree of distensibility detected by CTA.

Materials And Methods: Computed tomographic angiography was performed in 30 healthy adults and in 30 patients. All subjects were younger than 55 years.

Self-assembled poly(N-methylaniline)-lignosulfonate spheres: from silver-ion adsorbent to antimicrobial material.

Self-assembled poly(N-methylaniline)-lignosulfonate (PNMA-LS) composite spheres with reactive silver-ion adsorbability were prepared from N-methylaniline by using lignosulfonate (LS) as a dispersant. The results show that the PNMA-LS composite consisted of spheres with good size distribution and an average diameter of 1.03-1.

Controlled preparation and reactive silver-ion sorption of electrically conductive poly(N-butylaniline)-lignosulfonate composite nanospheres.

Electroconductive poly(N-butylaniline)-lignosulfonate (PBA-LS) composite nanospheres were prepared in a facile way by in situ, unstirred polymerization of N-butylaniline with lignosulfonate (LS) as a dispersant and dopant. The LS content was used to optimize the size, structure, electroconductivity, solubility, and silver ion adsorptive capacity of the PBA-LS nanospheres. Uniform PBA-LS10 nanospheres with a minimal mean diameter of 375 nm and high stability were obtained when the LS content was 10 wt %.

Facile preparation of hierarchical polyaniline-lignin composite with a reactive silver-ion adsorbability.

A hierarchical polyaniline-lignin (PANI-EHL) composite was facilely prepared from aniline and enzymatic hydrolysis lignin in an aqueous solution of ammonia. The morphology, FTIR, UV-vis spectra, thermogravimetric analysis, and wide-angle X-ray diffraction analyses of the composite were systematically investigated. Furthermore, the sorption property of the PANI-EHL composite for silver ions in aqueous solution was studied via a static sorption technique.

Long dwell-time exposure of human chorionic villi to transvaginal ultrasound in the first trimester of pregnancy induces activation of caspase-3 and cytochrome C release.

Bioeffects after exposure to ultrasound are correlated to its duration. Although diagnostic ultrasound has been suggested to induce apoptosis, the underlying signal transduction pathway remains elusive. In this study, women in the first trimester of pregnancy were exposed to transvaginal diagnostic ultrasound with 5.