Publications by authors named "Jia Yi Wu"
Article Synopsis
- The supramammillary nucleus (SuM) contains wake-promoting glutamatergic neurons that potentially influence consciousness levels during general anesthesia, specifically with sevoflurane.
- Research involved methods like in vivo fiber photometry and optogenetic manipulations to assess SuM neuron activity during different phases of sevoflurane anesthesia.
- Findings show that SuM neuron activity decreases when consciousness is lost and increases during recovery, indicating their crucial role in modulating sensitivity to anesthesia and states of cortical activation and behavior during the process.
Purpose: The prognosis of hepatocellular carcinoma (HCC) with extrahepatic metastases (EM) is poor. The efficacy and safety of transcatheter arterial chemoembolization combined with lenvatinib plus anti-programmed cell death 1 inhibitors (triple therapy) for HCC with EM remains unclear. In this study, we aimed to determine the efficacy and safety of triple therapy in HCC patients with EM.
View Article and Find Full Text PDFArticle Synopsis
- * PPARγ, a nuclear receptor involved in metabolism, plays a role in regulating genes linked to inflammation and pain relief, with reduced levels found in areas related to chronic pain in animal studies.
- * Evidence suggests that activating PPARγ with natural or synthetic agonists can help alleviate chronic pain by reducing inflammation and oxidative stress, making it a promising area for further research.
Introduction: Transarterial chemoembolization combined with lenvatinib and PD-1 inhibitor (triple therapy) has displayed encouraging clinical outcomes for unresectable hepatocellular carcinoma (uHCC). We aimed to explore the prognostic value of pathological response (PR) in patients with initially uHCC who underwent conversion surgery following triple therapy and identify predictors of major pathological response (MPR).
Methods: A total of 76 patients with initially uHCC who underwent conversion surgery following triple therapy were retrospectively analyzed.
Background: This study aimed to assess the effect of adjuvant therapy with different durations in patients with initially unresectable hepatocellular carcinoma (uHCC) after conversion surgery.
Methods: This study included 85 patients with initially uHCC who received conversion surgery between May 2019 and November 2022. They were divided into the long duration group (n = 57) and short duration group (n = 28) based on postoperative medication duration.
Integrated "Two-in-One" Strategy for High-Rate Electrocatalytic CO Reduction to Formate.
Angew Chem Int Ed Engl
January 2025
The electrochemical CO reduction reaction (ECR) is a promising pathway to producing valuable chemicals and fuels. Despite extensive studies reported, improving CO adsorption for local CO enrichment or water dissociation to generate sufficient H* is still not enough to achieve industrial-relevant current densities. Herein, we report a "two-in-one" catalyst, defective Bi nanosheets modified by CrO (Bi-CrO), to simultaneously promote CO adsorption and water dissociation, thereby enhancing the activity and selectivity of ECR to formate.
View Article and Find Full Text PDFPhoto-assisted Zn-air batteries can accelerate the kinetics of oxygen reduction and oxygen evolution reactions (ORR/OER); however, challenges such as rapid charge carrier recombination and continuous electrolyte evaporation remain. Herein, for the first time, piezoelectric catalysis is introduced in a photo-assisted Zn-air battery to improve carrier separation capability and accelerate the ORR/OER kinetics of the photoelectric cathode. The designed microhelical catalyst exploits simple harmonic vibrations to regenerate the built-in electric field continuously.
View Article and Find Full Text PDFComplex coumarins (CCs) represent characteristic metabolites found in Apiaceae plants, possessing significant medical value. Their essential functional role is likely as protectants against pathogens and regulators responding to environmental stimuli. Utilizing genomes and transcriptomes from 34 Apiaceae plants, including our recently sequenced Peucedanum praeruptorum, we conduct comprehensive phylogenetic analyses to reconstruct the detailed evolutionary process of the CC biosynthetic pathway in Apiaceae.
View Article and Find Full Text PDFIntroduction: Patients with hepatocellular carcinoma (HCC) and inferior vena cava tumor thrombus (IVCTT) have poor prognosis. Combination therapy involving the blockade of programmed cell death protein 1 (PD-1) and tyrosine kinase inhibitors is an efficient treatment strategy for advanced HCC. However, surgical treatment after a combination of systemic therapy and transarterial chemoembolization (TACE) for HCC with IVCTT has not been widely reported, and the efficacy and safety of this treatment have not been studied.
View Article and Find Full Text PDFA substantial proportion of diabetic patients suffer a debilitating and persistent pain state, known as peripheral painful neuropathy that necessitates improved therapy or antidote. Purpurin, a natural anthraquinone compound from Rubia tinctorum L., has been reported to possess antidepressant activity in preclinical studies.
View Article and Find Full Text PDFBackground: Portal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with macroscopic PVTT (macro-PVTT) and macroscopic BDTT (macro-BDTT).
View Article and Find Full Text PDFKey Clinical Message: In a patient with metastatic breast cancer, an acquired BRCA mutation in the BRCA gene was detected, resulting in benefits from olaparib treatment. This underscores the importance of ongoing genetic phenotype testing after paclitaxel chemotherapy.
Abstract: Triple-negative breast cancer (TNBC) is associated with a poor prognosis and elevated mortality risk.
Article Synopsis
- - Gaucher disease (GD) is a rare genetic disorder caused by a deficiency of the enzyme glucocerebrosidase due to mutations in the GBA1 gene, resulting in symptoms affecting multiple organs, particularly the liver, spleen, and bone marrow.
- - An adult male in China experienced severe splenic enlargement and related symptoms for 13 years, with his Gaucher disease diagnosis being delayed until a splenectomy revealed splenic Gaucher disease, highlighting the need for better awareness of rare diseases among healthcare providers.
- - Genetic analysis identified two mutations in the GBA1 gene in the patient, including a previously unreported one, which may disrupt protein structure and contribute to his non-neuronopathic type of Gau
Background: This study aimed to compare the survival outcomes of patients with initially unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) who underwent or did not undergo salvage surgery followed by a triple combination conversion treatment consisted of locoregional treatment (LRT), tyrosine kinase inhibitors (TKIs), and anti-PD-1 antibodies.
Methods: The data from 93 consecutive patients with initially unresectable HCC and PVTT across 4 medical centers were retrospectively reviewed. They were converted successfully by the triple combination treatment and underwent or did not undergo salvage resection.
Article Synopsis
- The study focuses on patients with hepatocellular carcinoma (HCC) without microvascular invasion (M0) and highlights the variability in their prognosis, sparking debate about the need for additional therapy after initial treatments like liver resection (LR) or liver transplantation (LT).
- Researchers developed the Eastern Hepatobiliary Surgery Hospital (EHBH)-M0 score using various clinical factors (including α-fetoprotein levels and tumor size) to classify these patients, revealing differing survival outcomes based on the score.
- The EHBH M0 scoring system proved to be more reliable than other existing staging systems in predicting patient prognosis, indicating that patients with higher scores could benefit from adjuvant therapies like transcatheter arterial
Article Synopsis
- Li-CO batteries are gaining interest for their ability to utilize greenhouse gases and store energy, but they face challenges like low operating voltage and poor energy efficiency due to high kinetic barriers in CO conversion.
- A new "trinity" Li-CO battery system was developed, combining carbon monoxide (CO), a soluble redox mediator (TEM RM), and reduced graphene oxide to enhance CO conversion to lithium carbonate (LiCO).
- This innovative design resulted in a higher output voltage of 2.97 V and round-trip efficiency of 97.1%, improving both reaction speed and rechargeability, paving the way for future battery advancements.
Background: Combination treatment with transcatheter arterial chemoembolization (TACE), lenvatinib, and anti-programmed death-1 (anti-PD-1) antibodies (triple therapy) has a high rate of tumor response and converted resection for initially unresectable hepatocellular carcinoma (uHCC) patients. This study aimed to assess the outcomes of salvage surgery in uHCC patients after conversion therapy with triple therapy.
Methods: uHCC patients who met the criteria for hepatectomy after receiving triple therapy as first-line treatment were eligible for inclusion in this study.
Article Synopsis
- * Studies show that certain proteins called matrix metalloproteinases (MMPs) are linked to chronic pain and can cause more pain when they are not working right.
- * Researchers believe that stopping or changing how MMPs work could help reduce chronic pain, and they are looking into drugs that could target MMPs for better treatment options.
In Brief: The proliferation of the endometrium is regulated by histone methylation. This study shows that decreased NSD2 impairs proliferative-phase endometrial stromal cell proliferation in patients with recurrent implantation failure via epigenetic reprogramming of H3K36me2 methylation on the promoter region of MCM7.
Abstract: Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism.
Aprotic lithium-oxygen (Li-O) batteries are considered to be a promising alternative option to lithium-ion batteries for high gravimetric energy storage devices. However, the sluggish electrochemical kinetics, the passivation, and the structural damage to the cathode caused by the solid discharge products have greatly hindered the practical application of Li-O batteries. Herein, the nonsolid-state discharge products of the off-stoichiometric LiO in the electrolyte solutions are achieved by iridium (Ir) single-atom-based porous organic polymers (termed as Ir/AP-POP) as a homogeneous, soluble electrocatalyst for Li-O batteries.
View Article and Find Full Text PDFBackground: The long-term prognosis after surgery of patients with hepatocellular carcinoma (HCC) and extrahepatic bile duct tumor thrombus (Ex-BDTT) remains unknown. We aimed to identify the surgical outcomes of patients with HCC and Ex-BDTT.
Methods: A total of 138 patients with Ex-BDTT who underwent hepatectomy with preservation of the extrahepatic bile duct from five large hospitals in China between January 2009 and December 2017 were included.
Background: This study aimed to determine whether salvage hepatectomy offers prognostic advantages for unresectable hepatocellular carcinoma (uHCC) patients with clinical complete response (cCR) after conversion therapy.
Methods: A total of 74 consecutive uHCC patients with cCR after conversion therapy at seven major cancer centers in China between October 2018 and December 2021 were included. One-to-one propensity score matching (PSM) was performed to minimize the influence of potential confounders.
Background And Aims: Transcatheter arterial chemoembolization combined with lenvatinib and PD-1 inhibitors (triple therapy) exhibits promising efficacy for unresectable hepatocellular carcinoma (uHCC). We aimed to evaluate the prognosis of patients with uHCC who received triple therapy and develop a prognostic scoring model to identify patients who benefit the most from triple therapy.
Methods: A total of 246 patients with uHCC who received triple therapy at eight centers were included and assigned to the training and validation cohorts.