The effect of H occupancy modes in small and large cages of H-tetrahydrofuran hydrates on the hydrates' stability and H storage capacity.

Hydrogen storage as hydrates is one of the most environmentally benign approaches to store hydrogen as it requires only water and traces of promoters. However, the scalability of storing hydrogen hydrate formation is hindered by the limited understanding of the structure, dynamics and energetics of hydrogen and promoters in the hydrate cages. In this study, molecular dynamics simulation configurations with different occupancy modes of H and tetrahydrofuran (THF) in the hydrate cages are investigated under the following scenarios: (i) two H molecules occupying the small cages, (ii) occupancy of H molecules in the THF-free large cages, and (iii) co-occupancy of H and THF in one large cage.

Antiviral prenylated C-C derivatives containing a methylenedioxyl group from the roots of Illicium brevistylum.

Five previously undescribed prenylated C-C compounds (1-3 and 5-6) and four known prenylated C-C compounds (4 and 7-9) were isolated from the roots of Illicium brevistylum A. C. Smith.

Algicidal mechanism and algicidal active metabolites of Alteromonas abrolhosensis against harmful dinoflagellates Karenia mikimotoi.

Harmful algal blooms (HABs) are a global environmental concern, posing significant threats to marine ecosystems and human health. Algicidal bacteria offer a promising biological approach for mitigating HABs. Herein, the mechanism of an algicidal bacterium Alteromonas abrolhosensis JY-JZ1 against Karenia mikimotoi was investigated and algicidal metabolites from the strain JY-JZ1 were analyzed.

SLCO1B1 Functional Variants, Bilirubin, Statin-Induced Myotoxicity, and Recent Sub-Saharan African Ancestry: A Precision Medicine Health Equity Study.

Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines. The objective of this precision medicine health equity study was to determine the clinical validity of understudied candidate functional SLCO1B1 variants common in people with 1,000 Genomes sub-Saharan African superpopulation (1KG-AFR-like) genetic similarity.

Significance of left ventricular strain in cardiac magnetic resonance for short-term prognosis in pediatric patients with acute lymphoblastic leukemia.

Background: The survival rate of pediatric leukemia patients has remarkably increased. Early identification of cardiotoxicity associated with chemotherapy and the detection of prognostic factors are essential for effective patient management.

Objective: To evaluate the prognostic value of parameters assessed by cardiac magnetic resonance imaging (MRI) in pediatric patients with acute lymphoblastic leukemia (ALL).

Lipidomics and Transcriptomics Revealed Dietary Complex Plant Extracts Improve Lipid Composition of in Sheep.

Dietary regulation of intramuscular fat (IMF) deposition and fatty acid composition offers an effective strategy to enhance meat nutritional value. As phytogenic supplements rich in bioactive compounds, complex plant extracts (CPE) have demonstrated potential in improving meat quality through lipid metabolism modulation while ensuring food safety. In this study, we used 36 female sheep, approximately 4 months old and with a similar weight (29.

Nomogram for overall survival in ampullary adenocarcinoma using the surveillance, epidemiology, and end results database and external validation.

Background: Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract. Currently, only a few cases have been reported, resulting in limited information on survival.

Aim: To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.

Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer.

Obstructions can occur during any stage of colorectal cancer (CRC) and correspond with poor prognosis. Obstructive colorectal cancer (OCRC) is harder and exhibits increased tumor budding and proliferation of myofibroblasts compared to non-obstructive CRC, suggesting that the occurrence of obstruction may be related to extracellular matrix (ECM) remodeling. Here, we found that CRC and OCRC samples differed substantially in ECM composition, specifically in collagen (newly formed and mature) and proteoglycans (including glycosaminoglycan, hyaluronic acid, and chondroitin sulfate).

Biomimetic Square Pyramidal N-Fe-N Single Sites with Optimized Electron Distribution for the Efficient Oxygen Reduction Reaction.

Single atom iron-nitrogen-carbon (Fe-N-C) catalysts with a planar Fe─N structure are widely investigated as potential alternatives to platinum-based materials for oxygen reduction reaction (ORR), while they still suffer from the imperfect adsorption and activation of reaction intermediates, limiting their reduction efficiency. Herein, a Fe single-atom catalyst with a biomimetic square pyramidal N-Fe-N site supported by honeycomb-like porous carbon (SA-FeN/HPC) is successfully prepared by a supramolecular confinement-pyrolysis strategy. Theoretical calculations unveil that the introduction of spatially axial N ligands effectively regulates the charge redistribution around the planar Fe─N active centers and confers Fe active moieties with appropriate adsorption strength for intermediates, thereby resulting in accelerated ORR kinetics.

Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation.

Ethnopharmacological Relevance: Vascular dementia (VaD) represents a frequently seen cognitive dysfunction syndrome and has ranks second among dementia subtypes following Alzheimer's disease. At present, Ditan Decoction (DTD), the traditional Chinese herbal prescription, is clinically applied in treating VaD. However, the material basis of its efficacy and therapeutic mechanism still remain unknown.

Mapping Knowledge Structure and Themes Trends of Ewing Sarcoma: A Text-Mining Study.

Background: Ewing sarcoma (ES) is a rare type of cancer that primarily affects children and young adults. In recent years, there have been notable advancements in the treatment of ES due to the introduction of neoadjuvant chemotherapy and targeted therapy, as well as a wealth of related studies in this field published by scholars around the world. However, there is still a lack of a comprehensive report to aid researchers in quickly understanding the knowledge structure and emerging trends of this area.

COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation.

Purpose: To evaluate the all-cause mortality rate and renal outcomes in patients with diabetes and chronic kidney disease (CKD) following hospital discharge for COVID-19.

Methods: This single-center prospective observational study included 187 discharged COVID-19 patients with diabetes and CKD, admitted between December 2022 and January 2023 at West China Hospital, Sichuan University. Cox regression analysis was used to assess mortality risk, and logistic regression was applied to identify risk factors for rapid CKD progression after discharge.

First-principles computational screening of Ngas adsorption by two-dimensional MN-MXene.

The capture and utilization of Nhas been limited by the development of high-performance Ncapture and storage materials, and exploring the adsorption mechanism of Nand searching for new and efficient Nadsorption materials are the key to solving this technological challenge. In this study, the adsorption properties ofandtwo-dimensional MN-MXene (M = Sc, Ti, V, Ni, Cu, Zn, Y, Zr, Nb, Mo, Ru, Rh, Pd, Ag, and Cd) on Nmolecules were investigated based on first principles. The results of cohesion energy, energy band structure and partition density indicate that the 15 MNs have excellent stability and electrical properties.

Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis.

Background: Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity in Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin accessibility of ESCC at single-cell level is imperative to understand how it activates oncogenes and contributes to the onset and metastasis of ESCC.

Methods: We performed single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) on cancerous and adjacent noncancerous tissues from four ESCC patients who were pathological staged as T1a, T2b, T3b, or T4a, to investigate whether regulatory elements are pivotal in instigating cellular heterogeneity during ESCC metastasis.

Association among financial toxicity, depression and fear of cancer recurrence in young breast cancer patient-family caregiver dyads: an actor-partner interdependence mediation model.

Purpose: This study aimed to investigate the depression situation and the mediating role of fear of cancer recurrence (FCR) in the relationship between financial toxicity and depression in young breast cancer (BC) patient-family caregiver dyads.

Methods: A total of 196 young BC patient-family caregiver dyads at four hospitals in China were investigated. The Comprehensive scores for financial toxicity based on patient-reported outcome measures, the Hospital Anxiety and Depression Scale, and the FCR Inventory Short Form were assessed.

Transition-metal-free phosphorylation of polyfluoroarenes with P(O)H compounds.

Herein, a base-promoted C-P(O) bond formation method has been developed for the phosphorylation of polyfluoroarenes through selective C-F bond cleavage. The high selectivity and mild, transition-metal-free conditions of this method underscore its potential for sustainable synthesis applications. This method expands the scope of polyfluoroarene functionalization, providing a valuable tool for incorporating phosphorus motifs in complex aromatic frameworks.

Anatomy of the Critically-Endangered Anji Salamander (Hynobius amjiensis) Provides New Insights Into Morphological Evolution of Salamanders.

The Anji Salamander (Hynobius amjiensis) is a critically-endangered amphibian endemic to the Tianmushan Mountain area in southeastern China. As most of its congeneric species in the ancestral salamander family Hynobiidae, the osteology of H. amjiensis has remained essentially unknown and has hampered efforts in understanding morphological evolutionary patterns of early salamanders.

3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair.

Biomimetic neural substitutes, constructed through the bottom-up assembly of cell-matrix modulus via 3D bioprinting, hold great promise for neural regeneration. However, achieving precise control over the fate of neural stem cells (NSCs) to ensure biological functionality remains challenging. Cell behaviors are closely linked to cellular dynamics and cell-matrix mechanotransduction within a 3D microenvironment.

Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments.

Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments. The physical signals of structural anisotropy offer significant potential for orchestrating multicellular regulation through physical contact and cellular mechanosensing pathways, irrespective of cell type. In this study, we developed a highly oriented anisotropic nanofiber hydrogel designed to provide directional guidance for cellular extension and cytoskeletal organization, thereby achieving pronounced multicellular modulation, including shape-induced polarization of macrophages, morphogenetic maturation of Schwann cells, oriented extracellular matrix (ECM) deposition by fibroblasts, and enhanced vascularization by endothelial cells.

Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis.

Background: Increased PD-1 expression on CD8+ T cells is considered as a hallmark for T-cell exhaustion, and is thought to be related to the prognosis of cancer patients. However, discrepant results have made it difficult to apply PD-1+CD8+T cells and tumor prognosis to clinical practice. Therefore, we conducted a meta-analysis to evaluate its prognostic value in human cancers.

Depression-related innate immune genes and pan-cancer gene analysis and validation.

Background: Depression, a prevalent chronic mental disorder, presents complexities and treatment challenges that drive researchers to seek new, precise therapeutic targets. Additionally, the potential connection between depression and cancer has garnered significant attention.

Methods: This study analyzed depression-related gene expression data from the GEO database.

Ursonic Acid Ameliorates HO-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.

Growing evidence suggests that plant compounds are emerging as a tremendous source for slowing the onset and progression of Alzheimer's disease (AD). Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid with some hypoglycemic, anticancer, and antiinflammatory activities. However, the pharmacological effects of UNA on AD are still unknown.

Advances in genetic diagnosis and therapy of hereditary heart disease: a bibliometric review from 2004 to 2024.

Hereditary heart disease (HHD) is a series of cardiac disorders associated with monogenic or polygenic abnormalities and is one of the leading causes of sudden death, particularly in young adults. The updated European Cardiology guideline for cardiomyopathies provides the first comprehensive summary of genotyping, imaging, and therapy recommendations for inherited cardiomyopathies, but still lacks a comprehensive discussion of research advances and future trends in genetic diagnosis and therapy of HHD. Our research aims to fill this gap.