Publications by authors named "Jia Xing Wang"
[Anti-tumor mechanism of traditional Chinese medicine via Hedgehog signaling pathway: a review].
Zhongguo Zhong Yao Za Zhi
November 2024
The Hedgehog(Hh) signaling pathway has the functions of improving embryogenesis and maintaining tissue homeostasis. By influencing the tumor microenvironment, intervening in cell apoptosis, and regulating angiogenesis, it is pivotal in the occurrence, progression, and recovery of various tumors. Therefore, targeting and inhibiting the abnormal activation of the Hh pathway has become a potential research strategy for alleviating and treating cancer.
View Article and Find Full Text PDFPrevious evidence indicates that the NDC80 complex, a conserved spindle microtubule-binding component of the kinetochore, is overexpressed and associated with prognosis in certain cancer types. Herein, we assessed the expression and prognostic value of NDC80 complex components in pan-cancer and interrogated their potential functions in tumor context through multiple databases and software. Our findings showed that the expression of NDC80 complex components was aberrant across almost all cancer types and correlated positively with poor prognosis at the pan-cancer level.
View Article and Find Full Text PDFCholangiocarcinoma (CCA) is a rare type of digestive tract cancer originating from the epithelial cells of the liver and biliary tract. Current treatment modalities for CCA, such as chemotherapy and radiation therapy, have demonstrated limited efficacy in enhancing survival rates. Despite the revolutionary potential of immunotherapy in cancer management, its application in CCA remains restricted due to the minimal infiltration of immune cells in these tumors, rendering them cold and unresponsive to immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFBackground: Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predict MSI and immunotherapy outcomes in GC.
Methods: This retrospective multicohort study included a total of 457 GC patients from two independent medical centers in China and The Cancer Imaging Archive (TCIA) databases.
Article Synopsis
- - COVID-19-associated acute kidney injury (AKI) increases the risk of in-hospital death and may lead to chronic kidney disease, prompting research into potential treatments, including a traditional Chinese herb.
- - The study identified eight key target genes linked to COVID-19 AKI, which interact with three major compounds (quercetin, luteolin, and kaempferol) that may help as therapeutic targets.
- - Findings suggest that the proteins encoded by IL6, VEGFA, and RELA could be targeted through the NF-κB signaling pathway, indicating potential for botanical drugs, like quercetin, in treating COVID-19 AKI and necessitating further research.
Article Synopsis
- Colon adenocarcinoma (COAD) has high mortality rates, making accurate prognostic assessments and tailored treatments crucial for patient care.
- The study found that expression of the GABRD gene was significantly higher in COAD patients and correlated with advanced cancer stages and poorer survival rates.
- GABRD is identified as an independent predictive biomarker related to immune cell infiltration in COAD, suggesting potential for its use in prognosis and treatment strategies.
Article Synopsis
- CL-11 is a new protein that helps in developing embryos, fighting infections, and dealing with diseases like cancer.
- Researchers found that when they removed CL-11 from mice, melanoma (a type of skin cancer) grew slower, showing that CL-11 helps cancer cells grow faster.
- High levels of the COLEC11 gene in human cancers are linked to worse survival, which indicates that targeting CL-11 could be a potential way to treat tumors.
When a multicarboxylate aromatic ligand, 3,5-di(2',4'-dicarboxylphenyl)benzoic acid (HL), was employed, five structurally similar lanthanide metal-organic frameworks (Ln-MOFs), {[PrL(OH)Cl(HO)]·4CHN} (), {[NdL(OH) (HO)]·4CHN} (), {[GdL(OH)(HO)]·4CHN} (), {[HoL(OH) (HO)]·4CHN} () and {[ErL(OH)(HO)]·4CHN} (), were synthesized and characterized. Single-crystal X-ray structural analyses disclosed that all five Ln-MOFs crystallize in the trigonal space group. They have three-dimensional mesoporous structure featuring the coexistence of binuclear and tetranuclear species as inorganic building units.
View Article and Find Full Text PDF[Differential Expression of Long Non-coding RNA Cancer Susceptibility Candidate 2 and Imprinted Gene H19 in Extrahepatic Cholangiocarcinoma].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2022
Article Synopsis
- The study aims to explore the roles of two long non-coding RNAs, CASC2 and H19, in extrahepatic cholangiocarcinoma (ECC) by comparing their expression levels in tumor samples and cell lines.
- Data from high-throughput sequencing and quantitative PCR reveal that CASC2 has higher expression levels in carcinoma tissue, while H19 is expressed at lower levels in the same context.
- Bioinformatics analysis suggests that CASC2 is associated with metabolic processes, whereas H19 is involved in organismal development, indicating potential roles in cancer progression and differentiation.
Article Synopsis
- The autonomic nervous system regulates heart rate fluctuations, playing a key role in human sleep stages, which can be analyzed using heart-rate variability (HRV).
- Three advanced models—fully connected neural networks (FCN), convolutional neural networks (CNN), and long short-term memory networks (LSTM)—were developed to classify sleep stages solely using HRV data from two public datasets.
- Among these models, the CNN outperformed others with high precision for sleep stages, achieving average accuracy of 91.72%, making it effective for home-based sleep detection.
Real-time evaluation of the fighting activities during a sudden unknown disaster like the COVID-19 pandemic is a critical challenge for control. This study demonstrates that the temporal variations of effluents from hospital sewage treatment facilities can be used as an effective indicator for such evaluation. Taking a typical infection-suffering city in China as an example, we found that there was an obvious decrease in effluent ammonia and COD concentrations in line with the start of city lockdown, and its temporal variations well indicated the major events happened during the pandemic control.
View Article and Find Full Text PDFProtective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis.
Arthritis Rheumatol
August 2021
Article Synopsis
- The study investigates the role of soluble C-type lectin, CL-11, in a mouse model of rheumatoid arthritis (RA) to understand its impact on autoimmune disorders.
- Findings indicate that mice lacking CL-11 showed more severe arthritis symptoms and increased levels of inflammatory responses compared to normal mice.
- Treatment with recombinant CL-11 reduced arthritis severity, and lower CL-11 levels in human patients correlated with higher disease activity, highlighting its potential protective role against RA.
Article Synopsis
- The study aims to evaluate how unilateral congenital ptosis affects eye development and vision in children aged 3 to 15 years.
- It involved 41 patients categorized into three severity groups based on their eyelid position, and compared their eye measurements with those of the unaffected eye.
- Results showed significant differences in the incidence of astigmatism and other visual metrics between ptotic eyes and fellow eyes, indicating that congenital ptosis can hinder proper eye development and increase the risk of amblyopia, especially in severe cases.
Background: Long non-coding RNAs (lncRNAs) have drawn growing attention because of the role which they play in various diseases, including colorectal cancer (CRC). However, the potential functions of lncRNA MCF2L antisense RNA 1 (MCF2L-AS1) in tumors remained largely unclear. The present study aimed to explore the clinical significance and the biological effects of lncRNA MCF2L antisense RNA 1 (MCF2L-AS1) in CRC.
View Article and Find Full Text PDFPurpose: Enhanced Recovery after Surgery has been proven effective for patients with gastrointestinal cancer. But radical enhanced recovery could also lead to adverse clinical outcomes. Compared with reports on the estimation of successful implementation of enhanced recovery, studies on risk factors of enhanced recovery failure are still lacking.
View Article and Find Full Text PDFProtective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice.
Arterioscler Thromb Vasc Biol
September 2020
Article Synopsis
- The study investigates the role of the C3a anaphylatoxin receptor (C3aR) in atherosclerosis, focusing on its potential protective effects against the disease.
- Researchers found that mice lacking C3aR developed more severe atherosclerosis, showing increased inflammation and immune cell recruitment in the aorta compared to control mice.
- The results suggest that C3aR helps regulate inflammation and promotes an anti-inflammatory macrophage state, indicating it could be an important target for managing atherosclerosis.
Purpose: Enhanced recovery after surgery programs has been applied extensively in laparoscopic colorectal surgery. However, several studies have found that some patients fail from ERAS programs. It is important to identify these patients so that remedial action can be taken in a timely manner.
View Article and Find Full Text PDFArticle Synopsis
- Single-incision laparoscopic sleeve gastrectomy (SILSG) is proposed as a less invasive option compared to conventional laparoscopic sleeve gastrectomy (CLSG) for obese patients, focusing on comparing surgical outcomes.
- A meta-analysis of 11 studies involving 1168 patients indicated that SILSG led to higher patient satisfaction regarding cosmetic scars, but there were no significant differences between SILSG and CLSG in other surgical outcomes.
- The findings suggest SILSG is a viable alternative to CLSG due to its cosmetic benefits, but more high-quality research is needed for definitive conclusions on long-term outcomes.
Purpose: Practical training models can be a viable and effective educational tool that allows surgeons to acquire specific surgical techniques or skills. However, a suitable animal training model for reconstruction after a pancreaticoduodenectomy (PD) has not yet been reported. Therefore, we explored the feasibility and safety of establishing an animal training model for digestive tract reconstruction after a simulated PD using mongrel dogs.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined how a new composite material, LiNbO@FeO, affects the nitrate removal and manganese (Mn) oxidation by a specific bacteria strain, sp. A14, focusing on optimizing conditions like Mn concentration, pH, and temperature.
- - Researchers found that the best results for nitrate removal (almost 100%) and Mn oxidation (71.59%) occurred at a pH of 7.0, 80 mg/L Mn concentration, and a temperature of 30°C using 300 mg/L of LiNbO@FeO.
- - Additionally, tests showed that A14's efficiency in denitrification with the composite material remained stable over ten consecutive batches, indicating its potential for repeated use
Article Synopsis
- MicroRNAs (miRNAs), particularly miR-331, are crucial for normal heart function, and changes in its expression are linked to conditions like atrial fibrillation and Marfan syndrome.
- This study focused on miR-331 in heart failure models, finding a significant increase in miR-331-3p during cardiac hypertrophy, while miR-331-5p levels remained stable.
- The research revealed that miR-331-3p negatively regulates JPH2, affecting excitation-contraction coupling and heart function, indicating that abnormal miR-331 expression contributes to heart failure.
Article Synopsis
- The study investigates the prognostic value of the ratio of hepatic stellate cells (HSCs) to γδT cells (SGR) in patients with hepatocellular carcinoma (HCC) to understand their contributions to patient outcomes.
- A total of 339 HCC patients were analyzed, revealing that a higher SGR is linked to poorer overall and recurrence-free survival, with validation through nomograms.
- Additionally, positive correlations were found between circulating tumor cell levels and SGR, indicating that patients with high SGR and elevated tumor cells may experience early recurrence.
Article Synopsis
- * This study followed 238 patients who underwent vitrectomy for PDR to assess the incidence of NVG and understand the risk factors involved.
- * Results showed a 4.6% incidence of NVG within two years post-surgery, with higher preoperative intraocular pressure and severe PDR being significant risk factors for developing this complication.
Both the C3a/C3aR and C5a/C5aR1 axes are regarded as important pathways for inducing and regulating inflammatory responses. It is well documented that the C5a/C5aR1 axis is a potent inflammatory mediator in the pathogenesis of many clinic disorders. However, our understanding of the role of the C3a/C3aR axis in renal disorders remains limited.
View Article and Find Full Text PDFA simultaneous denitrification and Cd (II) removal of strain CC1 was isolated from Li Jiahe oligotrophic reservoir of Xi'an (China). Strain CC1 was identified as Cupriavidus sp. The first-order reaction kinetics equation was to model kinetic processes of mixotrophic anaerobic denitrification and Cd(II) removal, which showed an optimal NO-N removal rate was obtained at the C/N ratio of 5.
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