Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion.

Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated. In this study, NPs injected via the tail vein were distributed in the brain and internal organs in a mouse model of chronic internal carotid occlusion.

Single-nucleus RNA sequencing-based construction of a hippocampal neuron atlas in mice with epileptic cognitive impairment.

The hippocampus plays a critical role in learning and memory, and mice with epileptic cognitive impairment exhibit hippocampal atrophy. However, there is still a lack of research on the hippocampal cell atlas related to these disorders. Here, we utilized snRNA-seq to characterize the transcriptomic changes in hippocampal neurons of drug-resistant epilepsy (DRE) cognitive-impaired mice.

HBXIP induces PARP1 via WTAP-mediated mA modification and CEBPA-activated transcription in cisplatin resistance to hepatoma.

Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA-binding protein that is involved in various biological functions, including DNA damage repair and transcription regulation. It plays a crucial role in cisplatin resistance. Nevertheless, the exact regulatory pathways governing PARP1 have not yet been fully elucidated.

Utility of the triglyceride-glucose index for predicting restenosis following revascularization surgery for extracranial carotid artery stenosis: A retrospective cohort study.

Background: Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are effective interventions for treating extracranial carotid artery stenosis (ECAS), but long-term prognosis is limited by postoperative restenosis. Carotid restenosis is defined as carotid stenosis >50% by various examination methods in patients after carotid revascularization. This retrospective cohort study examined the value of the triglyceride-glucose (TyG) index for predicting vascular restenosis after carotid revascularization.

Aicardi-Goutières syndrome type 7 in a Chinese child: A case report.

Background: is a protein-coding gene. Disorders associated with include Aicardi-Goutières syndrome (AGS) type 7 and Singleton-Merten syndrome type 1. Related pathways include RIG-I/MDA5-mediated induction of the interferon (IFN)-α/β pathway and the innate immune system.

Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma.

Sorafenib, which inhibits multiple kinases, is an effective frontline therapy for hepatocellular carcinoma (HCC). Ferroptosis is a form of iron-dependent programmed cell death regulated by lipid peroxidation, which can be induced by sorafenib treatment. Oncoprotein hepatitis B X-interacting protein (HBXIP) participates in multiple biological pro-tumor processes, including growth, metastasis, drug resistance, and metabolic reprogramming.

Light-Enhanced Ion Migration in Two-Dimensional Perovskite Single Crystals Revealed in Carbon Nanotubes/Two-Dimensional Perovskite Heterostructure and Its Photomemory Application.

Two-dimensional (2D) hybrid perovskite sandwiched between two long-chain organic layers is an emerging class of low-cost semiconductor materials with unique optical properties and improved moisture stability. Unlike conventional semiconductors, ion migration in perovskite is a unique phenomenon possibly responsible for long carrier lifetime, current-voltage hysteresis, and low-frequency giant dielectric response. While there are many studies of ion migration in bulk hybrid perovskite, not much is known for its 2D counterparts, especially for ion migration induced by light excitation.

A Small Lattice Change Induces Significant Dynamic Changes of CHNH Caged in Hybrid Perovskite Crystals: Toward Understanding the Interplay between Host Lattices and Guest Molecules.

Two perovskite-type compounds, (MA)[B'Co(CN)] (MA = methylammonium, B' = K(I) and Na(I)), have very similar structures, but exhibit marked differences in the phase and dielectric transitions. Solid state H NMR studies reveal the detailed dynamic changes of the caged methylammonium (MA) cations before and after the phase transitions, which are correlated with the different dielectric states of the compounds. Using solid state Co NMR, the dynamic changes of the host lattices before and after the transitions, which accompany the changes in the dynamics of the caged MA cations, are unveiled, demonstrating the intriguing interplay between the MA cations and the host lattices.

Change in rainfall drives malaria re-emergence in Anhui Province, China.

Malaria is re-emerging in Anhui Province, China after a decade long' low level of endemicity. The number of human cases has increased rapidly since 2000 and reached its peak in 2006. That year, the malaria cases accounted for 54.

[Using exploratory spatial data analysis (ESDA) on the regional distribution of human brucellosis in six provinces of north China: 2004 - 2007].

Based on data related to human brucellosis which was collected from the national notifiable infectious disease reporting system in the 6 provinces (Inner Mongolia, Shanxi, Heilongjiang, Shaanxi, Jilin and Liaoning) of north China from 2004 to 2007, at the county scale. Data would include age and gender standardized mortality ratios (SMRs) while ESDA was including histograms, box plots and box maps, global and local Moran's I statistics, etc. The global Moran's I values from 2004 to 2007 were 0.

Surveillance of hand, foot, and mouth disease in mainland China (2008-2009).

Objective: Since HFMD was designated as a class C communicable disease in May 2008, 18 months surveillance data have been accumulated to December 2009. This article was to describe the distribution of HFMD for age, sex, area, and time between 2008 and 2009, to reveal the characteristics of the epidemic.

Methods: We analyzed weekly reported cases of HFMD from May 2008 to December 2009, and presented data on the distribution of age, sex, area and time.

Sex differences in the incidence and case fatality rates from hemorrhagic fever with renal syndrome in China, 2004-2008.

Background: Differences between male and female individuals in response to infectious diseases are an overlooked global health problem.

Methods: The relationship between sex and disease outcome was examined in populations of patients with hemorrhagic fever with renal syndrome (HFRS) in mainland China, where most cases of hantavirus exposure occur. HFRS in China is diagnosed on the basis of symptoms and is confirmed with serological testing.

[Comparison on the performance of both temporal and temporal-spatial models for outbreak detection through China Infectious Diseases Automated-alert and Response System (CIDARS)].

Objective: To analyze the pilot results of both temporal and temporal-spatial models in outbreaks detection in China Infectious Diseases Automated-alert and Response System (CIDARS) to further improve the system.

Methods: The amount of signal, sensitivity, false alarm rate and time to detection regarding these two models of CIDARS, were analyzed from December 6, 2009 to December 5, 2010 in 221 pilot counties of 20 provinces.

Results: The sensitivity of these two models was equal (both 98.

[Preliminary application on China Infectious Diseases Automated-alert and Response System (CIDARS), between 2008 and 2010].

Objective: To analyze the results of application on China Infectious Diseases Automated-alert and Response System (CIDARS) and for further improving the system.

Methods: Amount of signal, proportion of signal responded, time to signal response, manner of signal verification and the outcome of each signal in CIDARS were descriptively analyzed from July 1, 2008 to June 30, 2010.

Results: A total of 533 829 signals were generated nationwide on 28 kinds of infectious diseases in the system.

[Application of exponential smoothing method in prediction and warning of epidemic mumps].

Objective: To analyze the daily data of epidemic Mumps in a province from 2004 to 2008 and set up exponential smoothing model for the prediction.

Methods: To predict and warn the epidemic mumps in 2008 through calculating 7-day moving summation and removing the effect of weekends to the data of daily reported mumps cases during 2005-2008 and exponential summation to the data from 2005 to 2007.

Results: The performance of Holt-Winters exponential smoothing is good.

Spatiotemporal dynamics of hemorrhagic fever with renal syndrome, Beijing, People's Republic of China.

We used geographic information systems to characterize the dynamic change in spatial distribution of hemorrhagic fever with renal syndrome (HFRS) in Beijing, People's Republic of China. The seasonal variation in its incidence was observed by creating an epidemic curve. HFRS was associated with developed land, orchards, and rice paddies.